Issue 20, 2020

Recent advances in organocatalytic asymmetric oxa-Michael addition triggered cascade reactions

Abstract

The oxa-Michael cascade reaction, as an important part of the Michael reaction, has also been significantly developed over the recent decade. This is because the problem of the reactivity and selectivity of the addition reactions of oxygen nucleophiles to conjugated systems has been solved by different organocatalysts and reaction conditions. Therefore, using various efficient strategies, many novel and potentially bioactive chiral compounds with excellent yields and stereoselectivities have been synthesized. In this review, we summarize the recent advances in organocatalytic asymmetric oxa-Michael addition triggered cascade reactions for the stereoselective synthesis of heterocyclic compounds.

Graphical abstract: Recent advances in organocatalytic asymmetric oxa-Michael addition triggered cascade reactions

Article information

Article type
Review Article
Submitted
25 Mai 2020
Accepted
13 Aug 2020
First published
14 Aug 2020

Org. Chem. Front., 2020,7, 3266-3283

Recent advances in organocatalytic asymmetric oxa-Michael addition triggered cascade reactions

Y. Wang and D. Du, Org. Chem. Front., 2020, 7, 3266 DOI: 10.1039/D0QO00631A

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