Issue 13, 2020

Cross-dehydrogenative coupling involving benzylic and allylic C–H bonds

Abstract

In recent years, the cross-dehydrogenative coupling (CDC) has demonstrated to be a powerful synthetic tool to form C–C bonds from two C–H bonds. This high atom-economic transformation is an attractive alternative to the classical substitution and coupling approaches for the benzylation and allylation of carbon centers, which rely on the reaction of adequately functionalized starting materials. This review emphasizes the utility of the CDC through the coupling of benzylic and allylic C–H bonds with C(sp)–H, C(sp2)–H and C(sp3)–H bonds.

Graphical abstract: Cross-dehydrogenative coupling involving benzylic and allylic C–H bonds

Article information

Article type
Review Article
Submitted
14 Mai 2020
Accepted
26 Mai 2020
First published
26 Mai 2020

Org. Chem. Front., 2020,7, 1717-1742

Cross-dehydrogenative coupling involving benzylic and allylic C–H bonds

I. Bosque, R. Chinchilla, J. C. Gonzalez-Gomez, D. Guijarro and F. Alonso, Org. Chem. Front., 2020, 7, 1717 DOI: 10.1039/D0QO00587H

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