Issue 7, 2019
From the journal:

Organic & Biomolecular Chemistry

A fast-response and highly specific Si-Rhodamine probe for endogenous peroxynitrite detection in living cells†

Junma Tang,a   Qiang Li,a   Zhiqian Guo ORCID logo *a  and  Weihong Zhu ORCID logo a  

* Corresponding authors

a State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Functional Materials Chemistry, and Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China
E-mail: guozq@ecust.edu.cn

Abstract

Peroxynitrite (ONOO−) is involved in a variety of physiological and pathological processes. We designed and synthesized a fluorescent probe SiNH based on Si-rhodamine. The nanoprobe SiNH encapsulated within the amphiphilic copolymer exhibited fast response within 10 s, and it was highly specific for ONOO− in aqueous solution. It is demonstrated that the nanoprobe SiNH is applicable for real-time tracing of endogenous ONOO− in living cells.

Graphical abstract: A fast-response and highly specific Si-Rhodamine probe for endogenous peroxynitrite detection in living cells

  • This article is part of the themed collection: New Talent
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Article information

DOI
https://doi.org/10.1039/C8OB01598H
Article type
Paper
Submitted
06 Jul 2018
Accepted
30 Jul 2018
First published
30 Jul 2018

Org. Biomol. Chem., 2019,17, 1875-1880

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A fast-response and highly specific Si-Rhodamine probe for endogenous peroxynitrite detection in living cells

J. Tang, Q. Li, Z. Guo and W. Zhu, Org. Biomol. Chem., 2019, 17, 1875 DOI: 10.1039/C8OB01598H

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