Issue 17, 2018

A novel core–shell structured upconversion nanorod as a multimodal bioimaging and photothermal ablation agent for cancer theranostics

Abstract

A multifunctional core–shell nanocomposite based on noble metal plasmons coated with upconversion material has emerged as a promising cancer theranostics nanoplatform that integrates properties such as multimodal imaging, photothermal effects, good biocompatibility, and efficient therapy. However, a reasonable combination of plasmons and upconversion materials, as well as increased penetration depth, has always challenged the anti-cancer efficiency. Here, a unique kind of fluorescent thermal-magnetic resonance core–shell upconversion nanostructure has been designed and fabricated to simultaneously achieve photothermal therapy (PTT) and multimodal imaging. Gold nanorods (GNRs) are used as the plasmon cores and NaGdF4 with rare-earth Yb3+/Er3+ ions co-doping are used as the upconversion luminescence (UCL) shells, merging into upconversion nanorods (UCNRs) of GNRs@NaGdF4:Yb3+,Er3+. An NaGdF4 shell synthesized by a hydrothermal method can substitute for the cetyltrimethylammonium bromide (CTAB) on the surface of GNRs, which offers the benefits of reducing toxicity and increasing biocompatibility. More significantly, the red and green emission of Yb3+/Er3+ couples convert near-infrared (NIR) into visible light, appropriately overlapping with absorbance of GNRs, which improves the photothermal conversion efficiency. Meanwhile, we designed small and low-aspect-ratio GNR cores for the absorption of UCNRs in vivo. Verification with evidence from in vivo and in vitro assays shows that these core–shell UCNRs exhibit a talented potential application in multimodal bioimaging and PTT.

Graphical abstract: A novel core–shell structured upconversion nanorod as a multimodal bioimaging and photothermal ablation agent for cancer theranostics

Supplementary files

Article information

Article type
Paper
Submitted
31 Okt 2017
Accepted
16 Jän 2018
First published
17 Jän 2018

J. Mater. Chem. B, 2018,6, 2597-2607

A novel core–shell structured upconversion nanorod as a multimodal bioimaging and photothermal ablation agent for cancer theranostics

C. Wang, C. Xu, L. Xu, C. Sun, D. Yang, J. Xu, F. He, S. Gai and P. Yang, J. Mater. Chem. B, 2018, 6, 2597 DOI: 10.1039/C7TB02842C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements