Issue 7, 2018

Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering

Abstract

The structural dynamics of insulin hexamer dissociation were studied by the photoinduced temperature jump technique and monitored by time-resolved X-ray scattering. The process of hexamer dissociation was found to involve several transient intermediates, including an expanded hexamer and an unstable tetramer. Our findings provide insights into the mechanisms of protien–protein association.

Graphical abstract: Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering

Supplementary files

Article information

Article type
Communication
Submitted
25 Jän 2018
Accepted
24 Mai 2018
First published
25 Mai 2018

Photochem. Photobiol. Sci., 2018,17, 874-882

Author version available

Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering

D. Rimmerman, D. Leshchev, D. J. Hsu, J. Hong, B. Abraham, I. Kosheleva, R. Henning and L. X. Chen, Photochem. Photobiol. Sci., 2018, 17, 874 DOI: 10.1039/C8PP00034D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements