Issue 11, 2016

Iterative catalyst controlled diastereodivergent synthesis of polypropionates

Abstract

Polypropionate fragments are synthesized using a combination of a copper-catalyzed asymmetric allylic alkylation, ruthenium-catalyzed cross-metathesis and iridium-catalyzed asymmetric allylic etherification. The use of an appropriate chiral ligand for each catalytic reaction allows access to 1,2-hydroxymethyl arrays with good to excellent control over the relative and absolute configuration of the different stereocenters.

Graphical abstract: Iterative catalyst controlled diastereodivergent synthesis of polypropionates

Supplementary files

Article information

Article type
Research Article
Submitted
12 Mai 2016
Accepted
06 Jul 2016
First published
07 Jul 2016

Org. Chem. Front., 2016,3, 1383-1391

Iterative catalyst controlled diastereodivergent synthesis of polypropionates

D. Roke, M. Fañanás-Mastral and B. L. Feringa, Org. Chem. Front., 2016, 3, 1383 DOI: 10.1039/C6QO00199H

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