Issue 11, 2016

Non-stabilized enolates – versatile nucleophiles in transition metal-catalysed allylic alkylations

Abstract

While in the early days of palladium-catalyzed allylic alkylations mainly stabilized carbanions, such as malonates, have been used as standard nucleophiles, during the last 10–15 years also non stabilized enolates became more and more popular. Efficient protocols have been developed allowing their highly regio- as well as stereoselective allylations. In addition, catalysts based on other transition metals enlarge the synthetic potential of these valuable transformations, since each metal (complex) shows its own, typical reaction behaviour. This review will cover the new developments in this fast developing field.

Graphical abstract: Non-stabilized enolates – versatile nucleophiles in transition metal-catalysed allylic alkylations

Article information

Article type
Review Article
Submitted
09 Mai 2016
Accepted
16 Aug 2016
First published
23 Aug 2016

Org. Chem. Front., 2016,3, 1541-1560

Non-stabilized enolates – versatile nucleophiles in transition metal-catalysed allylic alkylations

U. Kazmaier, Org. Chem. Front., 2016, 3, 1541 DOI: 10.1039/C6QO00192K

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