Mesoporous silica nanoparticles: importance of surface modifications and its role in drug delivery

Abstract

Mesoporous nanoparticles are special examples of silica nanoparticles. They are well known for their variety of applications in various fields including biomedicine. This has been attributed to their size, tenability and easily modifiable capabilities because of the presence of functional groups, and their biocompatibility. In this review, we specifically focus on different modes of surface modifications using amino propyl and organic chains which facilitate maximum drug loading and sustained release. This review provides complete information about the importance of surface modifications and their biological consequences that will be helpful to understand the use of MCM-41 and SBA 15 as suitable drug delivery systems.