Issue 21, 2011

Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes

Abstract

Carbohydrate derivatisation and glycocluster formation are both known to enhance avidity for lectin binding. Using a plant toxin and human adhesion/growth-regulatory lectins (inter- and intrafamily comparisons) the effect of their combination is examined. In detail, aromatic substituents were introduced at the 2-N or 3′-positions of N-acetyllactosamine and the products conjugated to two types of calix[n]arenes (n = 4, 6) viathiourea-linker chemistry.

Graphical abstract: Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes

Supplementary files

Article information

Article type
Communication
Submitted
26 Feb 2011
Accepted
31 Mär 2011
First published
26 Apr 2011

Chem. Commun., 2011,47, 6126-6128

Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes

S. André, C. Grandjean, F. Gautier, S. Bernardi, F. Sansone, H. Gabius and R. Ungaro, Chem. Commun., 2011, 47, 6126 DOI: 10.1039/C1CC11163A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements