Issue 17, 2011
From the journal:

Chemical Communications

A smart magnetic resonance imaging contrast agent responsive to adenosine based on a DNA aptamer-conjugated gadolinium complex†‡

Weichen Xua  and  Yi Lu*a  

* Corresponding authors

a Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois, USA
E-mail: yi-lu@illinois.edu
Fax: +1 217 244 3186
Tel: +1 217 333 2619

Abstract

We report a general strategy for developing a smart MRI contrast agent for the sensing of small molecules such as adenosine based on a DNA aptamer that is conjugated to a Gd compound and a protein streptavidin. The binding of adenosine to its aptamer results in the dissociation of the Gd compound from the large protein, leading to decreases in the rotational correlation time and thus change of MRI contrast.

Graphical abstract: A smart magnetic resonance imaging contrast agent responsive to adenosine based on a DNA aptamer-conjugated gadolinium complex

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Article information

DOI
https://doi.org/10.1039/C1CC10161G
Article type
Communication
Submitted
09 Jän 2011
Accepted
03 Mär 2011
First published
22 Mär 2011

Chem. Commun., 2011,47, 4998-5000

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A smart magnetic resonance imaging contrast agent responsive to adenosine based on a DNA aptamer-conjugated gadolinium complex

W. Xu and Y. Lu, Chem. Commun., 2011, 47, 4998 DOI: 10.1039/C1CC10161G

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