Issue 5, 2022

Coordination-assisted, transition-metal-catalyzed enantioselective desymmetric C–H functionalization

Abstract

Transition-metal-catalyzed asymmetric C–H functionalization has gradually emerged as a powerful tool for the creation of structural and chiral complexity in an atom- and step-economical fashion. The nature of this strategy provides a variety of methodologies to overcome the limitation of enantioselective desymmetrization caused by the synthesis of preformed multifunctional symmetric substrates. This review aims to summarise recent advances in transition-metal-catalyzed enantioselective desymmetric C–H functionalization reactions via coordination-assisted metal insertion, covering the literature from 2008 to June 2021. The mechanistic pathway and the modes of stereocontrol are discussed where appropriate.

Graphical abstract: Coordination-assisted, transition-metal-catalyzed enantioselective desymmetric C–H functionalization

Article information

Article type
Review Article
Submitted
18 Dez 2021
Accepted
06 Jän 2022
First published
07 Jän 2022

Org. Chem. Front., 2022,9, 1458-1484

Coordination-assisted, transition-metal-catalyzed enantioselective desymmetric C–H functionalization

X. Yu, Z. Zhang, J. Niu and B. Shi, Org. Chem. Front., 2022, 9, 1458 DOI: 10.1039/D1QO01884A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements