Issue 10, 2022

Recent advances in melt crystallization, towards process intensification and technique development

Abstract

Melt crystallization has been considered as a green separation technique and widely applied in industry and manufacture due to several attractive features, including no need for a solvent, achieving specific product properties, and several process merits. This paper systematically reviews process intensification approaches in melt crystallization. Firstly, process models are discussed based on the crystallization and sweating processes, and process models and parameters are summarized to describe the process efficiency, separation performance and inclusion migration rules. Secondly, the process intensification approaches are summarized based on technique innovation and device optimization. Lastly, the recent advanced applications of melt crystallization in pharmaceutical and ultrapure product preparation fields are also included. Furthermore, the critical concerns for further research and perspectives are proposed.

Graphical abstract: Recent advances in melt crystallization, towards process intensification and technique development

Article information

Article type
Highlight
Submitted
07 Jän 2022
Accepted
01 Feb 2022
First published
01 Feb 2022

CrystEngComm, 2022,24, 1823-1839

Recent advances in melt crystallization, towards process intensification and technique development

L. Shen and M. Dang, CrystEngComm, 2022, 24, 1823 DOI: 10.1039/D2CE00022A

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