Issue 30, 2021

Multiscale pore contained carbon nanofiber-based field-effect transistor biosensors for nesfatin-1 detection

Abstract

Nesfatin-1 (NES1) is a potential biomarker found in serum and saliva that indicates hyperpolarization and depolarization in the hypothalamic ventricle nucleus as well as an increase in epileptic conditions. However, real-time investigations have not been carried out to detect changes in the concentration of NES1. In this study, we develop a multiscale pore contained carbon nanofiber-based field-effect transistor (FET) biosensor to detect NES1. The activated multiscale pore contained carbon nanofiber (a-MPCNF) is generated using a single-nozzle co-electrospinning method and a subsequent steam-activation process to obtain a signal transducer and template for immobilization of bioreceptors. The prepared biosensor exhibits a high sensitivity to NES1. It can detect levels as low as 0.1 fM of NES1, even in the presence of other interfering biomolecules. Furthermore, the a-MPCNF-based FET sensor has significant potential for practical applications in non-invasive real-time diagnosis, as indicated by its sensing performance in artificial saliva.

Graphical abstract: Multiscale pore contained carbon nanofiber-based field-effect transistor biosensors for nesfatin-1 detection

Supplementary files

Article information

Article type
Paper
Submitted
18 Mär 2021
Accepted
30 Jun 2021
First published
30 Jun 2021

J. Mater. Chem. B, 2021,9, 6076-6083

Multiscale pore contained carbon nanofiber-based field-effect transistor biosensors for nesfatin-1 detection

S. G. Kim and J. S. Lee, J. Mater. Chem. B, 2021, 9, 6076 DOI: 10.1039/D1TB00582K

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