Recent advances in the total synthesis of cytochalasan natural products using bioinspired strategies
This review summarizes the recent advances in the bioinspired synthesis of cytochalasans, pentacyclic cytochalasans and merocytochalasans covering from 2016 to 2021.
Five-membered carbocycle construction in the synthesis of Daphniphyllum alkaloids: recent strategic and methodological advances
In this review article, we summarize novel or non-standard strategies and methods for the five-membered carbocycle construction in recent Daphniphyllum alkaloid synthesis.
Natural product total synthesis using rearrangement reactions
The synthetic utility of rearrangement reactions in total synthesis for the rapid construction of core skeletons, the precise control of stereochemistry, and the identification of suitable synthons has been discussed.
The application of C–H bond functionalization in the total syntheses of indole natural products
The recent advances in total synthesis of indole natural products focusing on the application of C–H bond functionalization are summarized.
A brief overview of classical natural product drug synthesis and bioactivity
This manuscript briefly overviewed the total synthesis and structure–activity relationship studies of eight classical natural products, which emphasizes the important role of total synthesis in natural product-based drug development.
The applications of catalytic asymmetric halocyclization in natural product synthesis
Catalytic asymmetric halocyclization of olefinic substrate has evolved rapidly and been well utilized as a practical strategy for constructing enantioenriched cyclic skeletons in natural product synthesis.
Metal-hydride hydrogen atom transfer (MHAT) reactions in natural product synthesis
Functionalization of olefins has been an important transformation in synthetic chemistry. This review will focus on the natural product synthesis employing the MHAT reaction as the key strategy.
About this collection
Welcome to Organic Chemistry Frontiers themed collection on natural product synthesis. Synthesis of natural products has been recognized as one of the most exciting and dynamic areas in organic chemistry. It serves as the most effective tool for preparing complex target molecules while significantly facilitating the development of chemical biology and drug discovery.
Guest edited by Professor Shuanhu Gao (East China Normal University, China), this themed collection features seven review articles around synthetic strategies for natural products. Read for a dose of inspiration from mother nature and organic chemistry!