Unveiling the potential of novel indol-3-yl-phenyl allylidene hydrazine carboximidamide derivatives as AChE/BACE 1 dual inhibitors: a combined in silico, synthesis and in vitro study

Amit Sharma, Santosh Rudrawar, Ankita Sharma, Sandip B. Bharate and Hemant R. Jadhav

RSC Adv., 2024,14, 23853-23872

Abstract

Considering the failure of many enzyme inhibitors for Alzheimer's disease (AD), research is now focused on multi-target directed drug discovery.

Design, synthesis, in silico, and in vitro evaluation of pyrrol-2-yl-phenyl allylidene hydrazine carboximidamide derivatives as AChE/BACE 1 dual inhibitors

Amit Sharma, Santosh Rudrawar, Ankita Sharma, Sandip B. Bharate and Hemant R. Jadhav

RSC Adv., 2024,14, 26703-26722

Abstract

Pyrrol-2-yl-phenyl allylidene hydrazine carboximidamide derivatives as AChE/BACE 1 dual inhibitors.

Evaluation of the underutilized Malpighia glabra L. fruits as a future functional food: nutritional composition, phenolic profile, biological activities, and synergistic effects with pharmaceutical drugs

Varongsiri Kemsawasd, Sirinapa Thangsiri, Yuraporn Sahasakul, Amornrat Aursalung, Woorawee Inthachat, Piya Temviriyanukul, Suwapat Kittibunchakul and Uthaiwan Suttisansanee

Food Funct., 2026,17, 3734-3748

Abstract

Malpighia glabra L., a non-commercial tropical fruit species in Thailand, was investigated regarding its nutritional composition, phenolic profile, and in vitro biological activities.

Seasonal variability and source diagnostics of ambient PAHs in Agra, India, using the CBPF and their health risk evaluation

Simran Bamola, Gunjan Goswami, Muskan Agarwal and Anita Lakhani

Environ. Sci.: Processes Impacts, 2026, Advance Article

Abstract

This study examines polycyclic aromatic hydrocarbons (PAHs) associated with total suspended particulates (TSP) in an understudied residential area of Agra, India, within the highly polluted Indo-Gangetic Plain, highlighting urban-industrial exposure.

Development, biological evaluation, and molecular modelling of novel isocytosine and guanidine derivatives as BACE1 inhibitors using a fragment growing strategy

Asmaa M. Atta, Nouran Rihan, Ahmad M. Abdelwaly, Mohamed S. Nafie, Mohamed S. Elgawish, Samia M. Moustafa, Mohamed A. Helal and Khaled M. Darwish

RSC Med. Chem., 2025,16, 2202-2230

Abstract

Drug-like molecules designed by fragment growing strategy on isocytosine and acyl guanidine warheads as BACE1 inhibition. In vivo characterization of top-active benzimidazoles (16a, 16k) showed Aβ/oxidation stress reduction and brain/liver safety.