The development of a palladium/norbornene-catalyzed four-component reaction, involving ortho C–H amination/ipso conjunctive coupling with an alkene and an external nucleophile, is reported.
We devised a modular approach involving glycosyl thiosulfonate-enabled ortho-C–H thioglycosylation and ipso-functionalization of aryl iodides/aryl boronic acids via palladium/norbornene cooperative catalysis and various terminations.
We demonstrate a robust palladium/norbornene-catalyzed deoxygenative ortho-benzylation of aryl iodides with non-derivatized benzyl alcohol, which enables the assembly of various diarylmethanes.
A Catellani-type α-alkoxycarbonylation/ipso-thiolation of enol triflates from ketones to access diverse tetrasubstituted vinyl sulfides has been developed.
A palladium/norbornene-catalyzed ortho-amination/allylation of aryl iodides was developed for the construction of ortho-aminated allylbenzene by using N-benzoyloxyamine as the amination reagent and homoallyl alcohol as the allylation reagent.