Competing hydrogen bonding and acyclic π-stacking between hydrogen-bridged quasi-rings in Z- and E-methyl pyruvate semicarbazone: a quantitative interaction energy analysis

Vidak Raičević, Niko S. Radulović, Nemanja Banić, Vukadin M. Leovac and Marko V. Rodić

CrystEngComm, 2025, 27, 7721
DOI: 10.1039/D5CE00911A

Copper-catalyzed synthesis of hydrazone derivatives using oxime esters and azodicarboxylates

Hengming Yang, Jiangna Yue, Hongda Xia, Chongchong Ma, Chenjie Lu, Xike Wang, Zhuochen Hu, Zhaoyang Yu, Xia Fan and Rongshun Chen

Org. Chem. Front., 2025, 12, 6575
DOI: 10.1039/D5QO00775E

Electrochemical N-sulfonylation of in situ generated indole-based hydrazones and antimicrobial evaluation

Parmjeet Kaur, Anuj Kumar, Tashi Palmo, Kuljit Singh and Vikas Tyagi

Org. Biomol. Chem., 2025, 23, 8948
DOI: 10.1039/D5OB01107H

Applications of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in heterocyclic ring formations

Ravi Varala, Murali Mohan Achari Kamsali, Mohamed Hussein and Mohammed Mujahid Alam

Org. Biomol. Chem., 2025, 23, 9285
DOI: 10.1039/D5OB01209K

Visible-light-induced cascade cyclization of N-acrylohydrazides toward functionalized pyrazolones and the application in drug modification

Sheng Yu, Yangjian Cheng, Changduo Pan and Jin-Tao Yu

Org. Biomol. Chem., 2025, 23, 8902
DOI: 10.1039/D5OB01389E

Catalytic electron donor–acceptor complex triggered cascade radical trifluoromethylation/cyclization of N-isopentenyl aldehyde hydrazones

Yangjian Cheng, Guocheng Yin, Changduo Pan and Jin-Tao Yu

Chem. Commun., 2026
DOI: 10.1039/D6CC00695G

Synthesis, Structural Elucidation, Supramolecular Assembly Exploration and DFT Study of a New Ketohydrazone Derivative

Malahat Kurbanova, Atazaz Ahsin, Arzu Sadigova, Abel Maharramov, Muhammad Ashfaq, Sabiya Osmanova, Hatem A. Abuelizz, Youness El Bakri, Suraj N. Mali and Rashad Al-Salahi

J. Comput. Biophys. Chem., 2026, 25, 1483
DOI: 10.1142/S2737416525501030

Access to C5-Sulfonylated Tetrahydropyridazines via Photoinduced Cascade Sulfonylation-Cyclization of N-Cinnamyl Aldehyde Hydrazones

Changduo Pan and Miao Zeng

J. Org. Chem., 2025, 90, 5672
DOI: 10.1021/acs.joc.5c00356

Exploring γ-Nitroketones as 1,4-Dicarbonyl Precursors for Annulation to Pyridazines through Interrupted Nef Reaction

Hitesh Kumar Labana, Shubham Tiwari, Ankush Gupta, Kalisadhan Mukherjee and Guddeangadi N. Gururaja

Org. Lett., 2026, 28, 3689
DOI: 10.1021/acs.orglett.6c00059

Radical Cascade Cyclization of Unsaturated Aldehyde Hydrazones for the Synthesis of Trifluoromethylated Tetrahydropyridazine and Dihydropyrazole Skeletons

Lian Ma, Ying Zhao and Guirong You

J. Org. Chem., 2026, 91, 440
DOI: 10.1021/acs.joc.5c02470

Photoinduced C–H Tetrafluoroethylation of Aldehyde Hydrazones with Freon 114B2

Changduo Pan, Wei Lin and Miao Zeng

J. Org. Chem., 2025, 90, 17741
DOI: 10.1021/acs.joc.5c02166

4,5-Dihydro-2H-pyridazin-3-ones as a Platform for the Construction of Chiral 4,4-Disubstituted-dihydropyridazin-3-ones

Paul Joël Henry, Gabriel Burel, William Nzegge, Mario Waser and Jean-François Brière

Molecules, 2025, 31, 83
DOI: 10.3390/molecules31010083

Visible Light-Induced Cyclization of N-Arylmethacrylohydrazides and Hydroxamic Acid Derivatives toward δ-Amidoalkylated Pyrazol-5-ones via 1,5-Hydrogen Atom Transfer

Yangjian Cheng, Guocheng Yin and Jin-Tao Yu

J. Org. Chem., 2026, 91, 1805
DOI: 10.1021/acs.joc.5c03039

Metal‐Free Nitration/Cyclization of Unactivated Olefins to Access Nitroated Tetrahydropyridazines with Sodium Nitrate

Xian Liu, Liqiang Hao, Xiao Yu, Shengkui Jin, Yiping Liu and Yafei Ji

Adv Synth Catal, 2025, 367
DOI: 10.1002/adsc.202500290

Access to 1-Aryl-pyrazolin-5-ones via Photocatalytic Chemoselective Tri/Difluoromethylation and Cyclization of N-Methacryloyl Aldehyde Hydrazones

Changduo Pan, Yanmei Gong and Miao Zeng

J. Org. Chem., 2025, 90, 9457
DOI: 10.1021/acs.joc.5c00861

Mechanisms and Synthetic Applications of Cyclic, Nonstabilized Isodiazenes: Nitrogen-Atom Insertion into Pyrrolidines and Related Rearrangements

Cecile Elgindy, Achyut R. Gogoi, Ángel Rentería-Gómez, Bumsu Park, Deborshee Das, Carys E. Obertone, Balu D. Dherange, Osvaldo Gutierrez and Mark D. Levin

J. Am. Chem. Soc., 2025, 147, 28179
DOI: 10.1021/jacs.5c08361

Integrated design and evaluation of a pyridazine-based SYK inhibitor: Synthesis, structural analysis, crystal engineering, DFT, MDs, and in vitro anticancer validation

Fares Hezam Al-Ostoot, P. Akhileshwari, Jigmat Stondus, Vivek H. Kameshwar, Majed S. Aljohani, Hussam Y. Alharbi, Ata Makarem, Hussien A. Khamees and Rajni Kant

Journal of Molecular Liquids, 2025, 439, 128790
DOI: 10.1016/j.molliq.2025.128790

Visible Light-Induced Radical-Cascade Difluoroalkylation/Cyclization of Unsaturated Aldehyde Hydrazones for the Synthesis of Difluoroalkylated Dihydropyrazoles and Tetrahydropyridazines

Hui Chen, Kaifa Zhang, Kun Xia, Yu Li, Ziwei Shan, Shuangming Zhang, Yonghong Zhang and Ablimit Abdukader

J. Org. Chem., 2025, 90, 8241
DOI: 10.1021/acs.joc.5c00708

Direct Photoinitiated Bromosulfonylation of Alkenes and Alkynes

Vladimir A. Abramov, Maxim A. Topchiy, Maria A. Rasskazova, Egor A. Drokin, Irina Beletskaya and Andrey F. Asachenko

Adv Synth Catal, 2025, 367
DOI: 10.1002/adsc.70053

Ferrocene-containing tetrahydropyridazines via domino chemistry

Kyrylo I. Tymoshenko, Svitlana V. Shishkina and Vitalii A. Palchykov

Journal of Molecular Structure, 2025, 1337, 142145
DOI: 10.1016/j.molstruc.2025.142145

Photoinduced Tandem Cyclization of Unsaturated Hydrazones with CF3CH2I to Access Trifluoroethylated Tetrahydropyridazines and Dihydropyrazoles

Guocheng Yin, Yangjian Cheng, Sheng Yu, Jin-Tao Yu and Changduo Pan

J. Org. Chem., 2026, 91, 2203
DOI: 10.1021/acs.joc.5c02897