Recent progress in lactate oxidase-based drug delivery systems for enhanced cancer therapy

Lu Li, Tian Yue, Jie Feng, Yujun Zhang, Jun Hou and Yi Wang

Nanoscale, 2024, 16, 8739
DOI: 10.1039/D3NR05952A

Beyond cisplatin: New frontiers in metallodrugs for hard-to-treat triple negative breast cancer

Nafees Muhammad, Muhammad Hanif and Piaoping Yang

Coordination Chemistry Reviews, 2024, 499, 215507
DOI: 10.1016/j.ccr.2023.215507

Enhancing the tissue penetration to improve sonodynamic immunotherapy for pancreatic ductal adenocarcinoma using membrane-camouflaged nanoplatform

Jiawei Du, Xin Chen, Xiaoxuan Xu, Ziting Que, Mengyan Zhai, Qinyanqiu Xiang, Zhiwei Zhang, Zhiqi Zhang, Yong Shao, Xue Yang, Fengqin Miao, Jianqiong Zhang, Jinbing Xie and Shenghong Ju

Eur J Nucl Med Mol Imaging, 2025, 52, 1119
DOI: 10.1007/s00259-024-06952-y

The Exosome‐Lactate‐Lactylation Axis: A Metabolic‐Epigenetic Circuit Driving Tumor Immune Evasion

Yuan Chen, Yuan Yuan, Zhen Zhang and Yihai Shi

Comprehensive Physiology, 2026, 16
DOI: 10.1002/cph4.70114

Dual-Responsive Cu(I) and Cu(II) Co-Doped Carbon Dots for Synergistic Chemodynamic-Photothermal Antitumor Therapy

Yujun Bao, Hui Zhang, Xiaodan Wu, Rui Yan, Zhiqiang Wang, Changhong Guo and Yingxue Jin

ACS Appl. Nano Mater., 2023, 6, 14410
DOI: 10.1021/acsanm.3c02418

A hyaluronic acid Schiff base @ hollow calcium peroxide @ copper carbon dots nanoconjugate enhances chemodynamic tumor therapy based on multiple approaches strategy

Xu Zhu, Yuting Lu, Minghao Sun, Xiaodan Wu, Hui Zhang, Zhiqiang Wang, Yingxue Jin and Guanghui Tan

International Journal of Biological Macromolecules, 2025, 311, 144039
DOI: 10.1016/j.ijbiomac.2025.144039

Active-oxygenating hollow Prussian blue nanosystems loaded with biomacromolecules for photodynamic/photothermal therapy of cancer and alleviating hypoxic tumors

Mingzhi Zhu, Pei Wang, Biaoqi Chen, Linrong Shi, Ruimin Long, Shibin Wang and Yuangang Liu

Materials & Design, 2024, 237, 112618
DOI: 10.1016/j.matdes.2023.112618

Lactate oxidase-integrated nanomaterials for tumor microenvironment modulation: Mechanisms and therapeutic applications

Xiaoxuan Xu, Di Chang, Yu Cai, Jue Wang, Jinqiang Liu, Peirong Xu and Yuanyuan Ma

Nano Biomedicine and Engineering, 2026, 18, 100001
DOI: 10.1016/j.nbe.2025.100001

Lactate and lactylation in cancer

Jie Chen, Ziyue Huang, Ya Chen, Hao Tian, Peiwei Chai, Yongning Shen, Yiran Yao, Shiqiong Xu, Shengfang Ge and Renbing Jia

Sig Transduct Target Ther, 2025, 10
DOI: 10.1038/s41392-024-02082-x

Advancements in the Application of the Fenton Reaction in the Cancer Microenvironment

Rile Ou, Gerile Aodeng and Jun Ai

Pharmaceutics, 2023, 15, 2337
DOI: 10.3390/pharmaceutics15092337

Smart MnO2 Nanosheet-Copper Carbon Dot Nanoplatform Enabling Multimodal Therapy to Reverse Hypoxia and Reprogram the Tumor Immune Microenvironment

Hui Zhang, Minghao Sun, Xu Zhu, Yuting Lu, Zhixiang Lan, Bo Yu, Xiaodan Wu and Yingxue Jin

ACS Appl. Mater. Interfaces, 2026
DOI: 10.1021/acsami.5c24938

Microenvironment-responsive BP@CuS-LOD hydrogel for synergistic catalytic lactate depletion and Cu²⁺ overload-induced pyroptosis in melanoma

Mengjin Chen, YuXuan Liu, Yizhan Tang, Zongyi Li, Ruofeng Yang, Yan Wei, Ziwei Liang, Weimo Han, Liqin Zhao and Di Huang

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2026, 728, 138760
DOI: 10.1016/j.colsurfa.2025.138760

The role of lactylation in breast cancer development: mechanisms, clinical translation and new strategies for treatment

Yanzhen Lu, Xiaoting Yang, Lulu Tan, Yunfei Yang, Dan Yu, Gang Feng and Yuyan Tan

Front. Oncol., 2025, 15
DOI: 10.3389/fonc.2025.1665097

A Copper/Ferrous‐Engineering Redox Homeostasis Disruptor for Cuproptosis/Ferroptosis Co‐Activated Nanocatalytic Therapy in Liver Cancer

Xiaoling Zhang, Jiuxin Zhu, Sihao Wang, Siyi Li, Jiaoting E, Jiahe Hu, Ruishu Mou, He Ding, Piaoping Yang and Rui Xie

Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202402022

Anti-Colon Cancer Activity of Copper-Doped Folate Carbon Dots/MnO2 Complexes Based on Oxygenation and Immune-Enhancing Effects

Mingyang Liu, Qing Xia, Xiaodan Wu, Siran Jin, Yutian Xie, Rui Yan, Yingxue Jin and Zhiqiang Wang

Bioconjugate Chem., 2024, 35, 826
DOI: 10.1021/acs.bioconjchem.4c00184

Nanotechnology-based strategies for ROS-mediated anticancer and antimicrobial therapies

Nadezhda A. Pechnikova, Malamati Poimenidou, Myra Lam, Mariia V. Aleksandrova, Yulia V. Ostankova, Amalia Aggeli and Alexey V. Yaremenko

Journal of Controlled Release, 2026, 114922
DOI: 10.1016/j.jconrel.2026.114922

A collective hyperthermia-facilitated glutathione inhibition strategy for boosted oxidative stress treatment

Wenting Li, Jihui Zhou, Yangyang Zhang, Shikai Liu, Rumin Li, Shili Gai, He Ding, Lei Zhong and Piaoping Yang

Chemical Engineering Journal, 2024, 485, 150056
DOI: 10.1016/j.cej.2024.150056

“Three Musketeers” Enhances Photodynamic Effects by Reducing Tumor Reactive Oxygen Species Resistance

Wencheng Xu, Yanrong Qian, Luying Qiao, Lei Li, Yulin Xie, Qianqian Sun, Zewei Quan and Chunxia Li

ACS Appl. Mater. Interfaces, 2024, 16, 26590
DOI: 10.1021/acsami.4c04278

Metabolite to Modifier: Lactate and Lactylation in the Evolution of Tumors

Long Zhao, Haoyue Cui, Yutong Li, Yingjiang Ye and Zhanlong Shen

MedComm, 2025, 6
DOI: 10.1002/mco2.70413