Recent advances in DNAzymes for bioimaging, biosensing and cancer therapy

Pei Sun, Hongquan Gou, Xinran Che, Guifang Chen and Chang Feng

Chem. Commun., 2024, 60, 10805
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MOF-mediated dual energy transfer nanoprobe integrated with exonuclease III amplification strategy for highly sensitive detection of DNA

Xiaojing Xing, Mengying Gao, Minglin Lei, Kunqi Cheng, Yifan Zhao, Xianchao Du, Luyi Zong, Dongfang Qiu and Xueguo Liu

Anal. Methods, 2024, 16, 1916
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Novel specific binding of copper ions to naturally modified base pairs involving 5-fluorouracil in duplex DNA

Hidetaka Torigoe, Kei Hirabayashi, Saki Adachi and Jiro Kondo

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Intratumoral microbiota: a new perspective in cancer initiation, development, and therapy

Huiling Liu, Zhonghui Luo, Fangzhen Luo, Xilian Wang, Hua Wei and Cui-Yun Yu

RSC Pharm., 2025, 2, 865
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Porous reticular Co@Fe metal–organic gel: dual–function simulated peroxidase nanozyme for both colorimetric sensing and antibacterial applications

Meng Wang, Xiaoguang Zhu, Yannan Yin, Guixia Ling and Peng Zhang

J. Mater. Chem. B, 2024, 12, 5418
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Recent progress in functional metal–organic frameworks for bio-medical application

Wenwen Chai, Xiaochen Chen, Jing Liu, Liyan Zhang, Chunyu Liu, Li Li, John Robert Honiball, Haobo Pan, Xu Cui and Deping Wang

Regenerative Biomaterials, 2024, 11
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Nanozymes‐Mediated Cascade Reaction System for Tumor‐Specific Diagnosis and Targeted Therapy

Ruru Xiong, Xiaoguang Zhu, Jiuhong Zhao, Guixia Ling and Peng Zhang

Small Methods, 2024
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Molecularly imprinted polymer-combined with metal organic frameworks (MIP/MOFs) for ratiometric fluorescence sensing applications

Kawan F. Kayani

Talanta, 2026, 299, 129142
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Co-delivery of vitamin and amino acid within MOFs for oxidative stress-based tumor gas therapy

Xueping Yan, Peng Jing, Zitian Zhuang, Jianing Zhang, Haiming Chen, Tifeng Xia and Ke Jiang

Journal of Colloid and Interface Science, 2025, 680, 518
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Engineered nanozymes for speedy colorimetric biosensing and sensitive cascaded-catalytic determining of norfloxacin

Xiaoguang Zhu, Jiaqi Xu, Yuanke Zhang, Guixia Ling and Peng Zhang

Applied Surface Science, 2024, 660, 159981
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Programmable DNAzyme walkers on gold nanoplatforms: From rational design to bioimaging/biosensing breakthroughs

Keqing Wang, Wenjing Zhu, Xin Li, Guixia Ling and Peng Zhang

Acta Biomaterialia, 2025, 206, 74
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Biomimetic mineralization-driven in situ encapsulation of cellulase into ZIF-8: Enhanced enzyme stability and pH-responsive release

Jun Yang, Guancheng Jiang, Maen M. Husein, Wei Zhang, Shengming Huang, Fuyan Kang, Tengfei Dong, Yinbo He and Lili Yang

Chemical Engineering Journal, 2025, 522, 167487
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Metal surface-triggered DNAzyme catalysis for efficient DNA cleavage

Fangning Jiang, Yan Dong, Wenqian Yu, Huiyu Tian, Longping Yang, Ziyi Jia, Yongjie Sheng, Dayong Si, Jiacui Xu and Dazhi Jiang

Commun Chem, 2026, 9
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“Jack-of-All-Trades” properties of nanozyme opens up an innovative pathogen detection model based on multi-function sensing platform

Qingnian Wu, Yujie Song, Tao Wen, Chenchen Jin, Defen Feng, Ke-Jing Huang, Yu Ya and Jing Xu

Chemical Engineering Journal, 2025, 523, 168113
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Metal-organic frameworks as functional materials for biomedicine

Zefan Sang, Guangxun Zhang, Yuping Li and Huan Pang

Sci. China Mater., 2026, 69, 94
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Metal and Covalent Organic Frameworks Meet OB‐GYN: Advancing Applications in Women's Health and Pregnancy Care

Yue Shi, Muling Zeng, Eudald Casals, Gregori Casals and Ning Liu

Small, 2025, 21
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Ultrasound‐Activated Theranostic Materials and Their Bioapplications

Kang Zhu, Jimei Wang, Zhao Wang, Qing Chen, Jibin Song and Xiaoyuan Chen

Angew Chem Int Ed, 2025, 64
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A novel dual-mode biosensing platform based on Au@luminol and CdSe QDs for detection of trace heavy metal ions in PM2.5

Qianqian Cai, Yutong An, Feng Guo and Guifen Jie

Biosensors and Bioelectronics, 2025, 278, 117366
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Dynamic regulation of ROS stress in the accumulation of L-lysine in Escherichia coli

Li Zhang, Jianan Yang, Zhixuan Lv, Longjun Han, Zhiwei Zha, Zhijie Cheng, Xu Yang, Zhengyang Xu, Lei Yang and Jian Gao

Journal of Biotechnology, 2026, 411, 66
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Ultrathin Metal–Organic Framework as an Allosteric Regulator for Albumin‐Responsive Therapy of Diabetic Infections

Yongming Li, Rao Wei, Huixia Feng, Ling Lei, Jian Chen, Han Gao, Rui Zhao, Hai‐Yu Hu and Yanyan Huang

Advanced Materials, 2026
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Solvent-free synthesis of defective Zr-based metal–organic framework from waste plastic bottles for highly efficient lomefloxacin removal

Hongliang Huang, Yu Heng, Zhihong Yu, Xinru Zhang, Xusang Zhu, Zhi Fang, Jian Li and Xiangyu Guo

Journal of Colloid and Interface Science, 2024, 670, 509
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Homogeneous Catalysis and Enzyme Mimics Catecholase, Phenoxazine Synthase and Tyrosinase Pathways

Oussama Riouchi, Mohamed El Boutaybi, Zakariae Abbaoui and Rachid Touzani

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Dual-Cascade Activated DNAzyme Nanoreactor within a Zn-Based MOF for Mitochondrial Gene Regulation

Xiuyan Wan, Yukun Tao, Yingli Ge, Wei Pan, Peng Miao, Na Li and Bo Tang

ACS Appl. Mater. Interfaces, 2025
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Hydrogel colorimetric microneedle patches embedded with dual-enzyme active metal-organic frameworks for glucose detection

Huishuang Li, Wenjing Wei, Xuanxuan Wang, Ruru Xiong, Guixia Ling and Peng Zhang

Materials Today Chemistry, 2026, 53, 103603
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Nanocatalytic medicine enabled next-generation therapeutics for bacterial infections

Min Ge, Feng Jiang and Han Lin

Materials Today Bio, 2024, 29, 101255
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Anthracene‐Based Endoperoxides as Self‐Sensitized Singlet Oxygen Carriers for Hypoxic‐Tumor Photodynamic Therapy

Yan‐Qin He and Jian‐Hong Tang

Adv Healthcare Materials, 2025, 14
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Spatial Confinement of a Dual Activatable DNAzyme Sensor in the Cavity of a DNA Nanocage for Logic‐Gated Molecular Imaging

Tingting Tu, Shuangyan Huan, Xueyan Feng, Guoliang Ke, Lele Li and Xiao‐Bing Zhang

Angew Chem Int Ed, 2025, 64
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Advances and applications of metal–organic framework/molecularly imprinted polymer (MOF/MIP) for fluorescence detection

Yuxuan Mao, Ruru Xiong, Jingjing Tian, Guixia Ling and Peng Zhang

Coordination Chemistry Reviews, 2025, 537, 216691
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Current landscape of metal–organic framework-mediated nucleic acid delivery and therapeutics

Shiwei Feng, Yan Li, Zheng Tan and Shiyang Shen

International Journal of Pharmaceutics, 2025, 672, 125295
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Logic-gated, triple-responsive DNAzyme nanoplatform for precise hepatocellular carcinoma treatment

Xiuyan Wan, Xincheng Qiao, Yu Zhang, Wei Pan, Na Li and Bo Tang

Chinese Chemical Letters, 2025, 112093
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A universal strategy based on a multifunctional DNAzyme biomineralized nanodevice for imaging low-abundance proteins

Wei Guo, Mingzhu Fan, Zhisheng Sun, Huakui Huang, Guichun Mo, Zhihui Luo, Jiayao Xu, Ling Liang and Shulong Wang

International Journal of Biological Macromolecules, 2026, 361, 152019
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Allosteric stem-loop multicomponent DNAzyme: A versatile stimuli-responsive switch for nanotweezer operations and multifunctional biosensing

Yaoyi Zhang, Dan Bai, Jiu Pu, Li Zhang, Weitao Wang, Tong Feng, Jianhong Zhang, Hongyan Yu, Xiaole Han, Ke Lv, Li Wang, Yongcan Guo and Guoming Xie

Chemical Engineering Journal, 2024, 499, 156044
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DNAzyme@MOF breaking pH limitation for the detection of dopamine in the interstitial fluid

Jiuhong Zhao, Jinnan Zhao, Xiaoyu Zhang, Guixia Ling and Peng Zhang

Biosensors and Bioelectronics, 2025, 279, 117367
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Click chemistry-driven functional nanocarrier engineering: Interdisciplinary progress from precise assembly to personalized theranostics

Chengke Ding, Baomei Zhang, Keyang Li, Qiuyue Wang, Xue Zhang, Xutao Ma, Qingqing He, Zerui Li, Hui Xin, Xinlei Meng, Pengfei Cui and Zhiyu He

Coordination Chemistry Reviews, 2026, 557, 217743
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CRISPR-integrated metal-organic frameworks for biosensing applications: Recent advances and future perspective

Babak Mikaeeli Kangarshahi, Anahita Beigi Javazm and Seyed Morteza Naghib

Sensing and Bio-Sensing Research, 2025, 47, 100736
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Carboxylate embedded metal organic frameworks for potential applications in drug delivery and controlled release

Hazrat Bilal, Sana Zahoor, Muhammad Iqbal Choudhary, Farzana Shaheen, Sukanya Dej-adisai, Hong Liang and Zhen-Feng Chen

Coordination Chemistry Reviews, 2025, 538, 216688
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Smart hydrogel sensors: advancing from highly sensitive detection to an integrated platform for miRNA diagnosis and treatment

Xiaoyu Zhang, Yuanke Zhang, Wenjing Wei, Guixia Ling and Peng Zhang

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Deciphering the signal of metal ions: the principle, design and multi-field application of DNAzyme fluorescence sensor

Tingyu Jing, Lvyao Yang, Ziyi Yuan, Guixia Ling and Peng Zhang

Talanta, 2026, 305, 129597
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Intelligent DNA Nanosystem for Broad-Spectrum Oncological Typing and Therapy

Lina Zhu, Yuxi Zhang, Jiani Ding, Wenjuan Xin, Gao-Chao Fan, Zhi-Ling Song, Peisen Zhang and Xiliang Luo

ACS Sens., 2024, 9, 6655
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Unveiling non-monotonic deformation of flexible MOFs during gas adsorption: From contraction and softening to expansion and hardening

Shivam Parashar, Nicholas J. Corrente and Alexander V. Neimark

Journal of Colloid and Interface Science, 2025, 686, 88
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Ultrasound‐Activated Theranostic Materials and Their Bioapplications

Kang Zhu, Jimei Wang, Zhao Wang, Qing Chen, Jibin Song and Xiaoyuan Chen

Angewandte Chemie, 2025, 137
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Construction of Functional Metal-Organic Frameworks and Their Applications in the Biomedical Field

Siyu Wang, Yutong Dai, Jing Zhang, Yiling Tong, Jingru Yang, Songyao Liu, Zhifeng Dai and Xiangju Meng

Chem. Res. Chin. Univ., 2026, 42, 63
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Enhanced enzyme-like DNAzyme@MOFs for non-enzymatic uric acid detection in interstitial fluid

Jiuhong Zhao, Wenjing Zhu, Yuxuan Mao, Guixia Ling and Peng Zhang

Chemical Engineering Journal, 2024, 500, 156837
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Metal organic framework–based variable-size nanoparticles for tumor microenvironment-responsive drug delivery

Yu Wang, Nan Gao, Xiaodan Li, Guixia Ling and Peng Zhang

Drug Deliv. and Transl. Res., 2024, 14, 1737
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Yi-Bin Yu, Qi Zhang, Yi-Hao Guo, Jia-Jun Wu, Ling-Xiao Zhao, Zhuo Wang, Zhi-Qiang Gong, Ya-Kun Kan and Zhan-You Wang

Chemical Engineering Journal, 2025, 511, 161784
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Revealing the synergistic impacts of ZIF-8 and copper co-exposure on zebrafish behavior, tissue damage, and intestine microbial community

Wenbin Li, Weiping Xiong, Siying He, Fang Li, Yalin Chen, Zhongwu Li, Zhaohui Yang, Zhuotong Zeng and Biao Song

Environmental Research, 2025, 269, 120922
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Enzyme and nanozyme biosensors based on MOFs for pesticide detection

Yijie Wang, Hongxia Li and Xu Yan

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Emerging adsorbents: Applications of sodium alginate/graphene oxide composite materials in wastewater treatment

Huishuang Li, Xiaoguang Zhu, Jiuhong Zhao, Guixia Ling and Peng Zhang

Journal of Water Process Engineering, 2024, 59, 105100
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Metal–Organic-Framework-Based Optical Biosensors: Recent Advances in Pathogen Detection and Environmental Monitoring

Alemayehu Kidanemariam and Sungbo Cho

Sensors, 2025, 25, 5081
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Target-Triggered Cascaded Self-Feedback DNAzyme Circuit Loaded in ZIF-8 for Highly Sensitive miRNA Imaging in Living Cells

Ting Huang, Naihan Huang, Qianying Zhou, Baoping Xie, Wenjun Duan, Bin Sun, Zong Dai, Jun Chen and Jin-Xiang Chen

Anal. Chem., 2025, 97, 7555
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Single-Molecule Detection Technologies: Advances in Devices, Transduction Mechanisms, and Functional Materials for Real-World Biomedical and Environmental Applications

Sampa Manoranjan Barman, Arpita Parakh, A. Anny Leema, P. Balakrishnan, Ankita Avthankar, Dhiraj P. Tulaskar, Purshottam J. Assudani, Shon Nemane, Prakash Rewatkar, Madhusudan B. Kulkarni and Manish Bhaiyya

Biosensors, 2025, 15, 696
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Climate friendly MOFs synthesis for drug delivery systems by integrating AI, intelligent manufacturing, and quantum solutions in industry 6.0 sustainable approach

Maryam Akhtar, Hammad Majeed, Tehreema Iftikhar and Khalil Ahmad

Toxicology Research, 2024, 14
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Recent advances in metal–organic framework/biomolecule hybrids for biomarker detection and bioimaging

Huafeng Wang, You Wu, Xinyi Wang, Fan Wu, Wenwen Tu, Wei Li and Zhihui Dai

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Porphyrin-Based Metal–Organic Frameworks for PD-L1 Detection via “Coordination Disaggregation-Induced Enhancement” Strategy

Weiming Gong, Xiaoran Wu, Dan Ren, Xinyi Feng, Shujun Wang, Yue Zhang, Yueyuan Li, Maojin Tian, Yueyun Li and Qing Liu

Langmuir, 2025, 41, 6894
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Recovering skin-nerve interaction by nanoscale metal-organic framework for diabetic ulcers healing

Xiuru Ji, Jingwei Zhou, Zengding Zhou, Zeyang Liu, Li Yan, Yuhan Li, Haiyan Guo, Weijie Su, Han Wang and Dalong Ni

Bioactive Materials, 2024, 42, 112
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Recent advances in zeolitic imidazolate frameworks as drug delivery systems for cancer therapy

Yuhan Wang, Yixin Tang, Lei Guo, Xi Yang, Shanli Wu, Ying Yue and Caina Xu

Asian Journal of Pharmaceutical Sciences, 2025, 20, 101017
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DNA-functionalized MOF fluorescent probes for the enzyme-free and pretreatment-free detection of MicroRNA in serum

Jiameng Xu, Xia Cui, Lu Wang, Guoning Chen, Shuhua Ji, Shiwei Zhao, Hui Wang, Zhimin Luo, Aiguo Zeng and Qiang Fu

Talanta, 2024, 275, 126083
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Application of Nanomaterial-Based Sonodynamic Therapy in Tumor Therapy

Nan Yang, Jianmin Li, Shujie Yu, Guoyu Xia, Dingyang Li, Longlong Yuan, Qingluo Wang, Lijun Ding, Zhongxiong Fan and Jinyao Li

Pharmaceutics, 2024, 16, 603
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Increment entropy promoted small-polaron breakdown in metal–organic frameworks for sodium-ion batteries

Changchun Ai, Zhian Yang, Guoshuai Shi, Yongping Xue, Hongmei Dai, Qun Yi, Chun Fang and Jiantao Han

Chemical Engineering Journal, 2024, 500, 157006
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Spatial Confinement of a Dual Activatable DNAzyme Sensor in the Cavity of a DNA Nanocage for Logic‐Gated Molecular Imaging

Tingting Tu, Shuangyan Huan, Xueyan Feng, Guoliang Ke, Lele Li and Xiao‐Bing Zhang

Angewandte Chemie, 2025, 137
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Rational design of CuCo-ZIF@HHTP heterojunction nanozyme via MOF-on-MOF strategy for efficient colorimetric sensing of quercetin

Jianlong Li, Maoyuan Hu, Yao Jin, Sheng Li and Xiaoli Xiong

Microchemical Journal, 2026, 220, 116408
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Metal-organic frameworks for nutraceutical delivery: A futuristic perspective

P. Santhoshkumar and J.A. Moses

Process Biochemistry, 2025, 149, 85
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