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A smart nanopaper sensor for optical diagnosis ofHelicobacter pyloriinfection
Zeinab Asghari Adib, Amir Reza Sharifi, Mohammad Ali Kiani, Hossein Yousefi, Daniel Horák, Uliana Kostiv, Ali Nabavi-Rad, Abbas Yadegar, Mohammad Yaghoubi-Avini and Hamed Golmohammadi
Mater. Adv., 2023, 4, 4965
DOI: 10.1039/D3MA00612C

Photochemical modifications for DNA/RNA oligonucleotides
Amirrasoul Tavakoli and Jung-Hyun Min
RSC Adv., 2022, 12, 6484
DOI: 10.1039/D1RA05951C

Recent progress on DNAzyme-based biosensors for pathogen detection
Xingxing Liu, Wenxu Yuan and Heng Xiao
Anal. Methods, 2024, 16, 4917
DOI: 10.1039/D4AY00934G

Chemiluminescence resonance energy transfer-based multistage nucleic acid amplification circuits for MiRNA detection with low background
Nana Kang, Benrui Weng, Sijia Liu, Huiran Yang, Siyuan Wang, Yaqi Liu, Jiabing Ran, Hanghang Liu, Zhangshuang Deng, Changying Yang, Huimin Wang and Fuan Wang
Analyst, 2023, 148, 2683
DOI: 10.1039/D3AN00594A

A LEGO-inspired multipiece chip for portable nucleic acid detection
Ye Peng, Lu Gao, Pengkun Yin, Tianyu Dong, Ke Yi and Feng Li
Chem. Commun., 2026, 62, 5678
DOI: 10.1039/D6CC00138F

Recent advances in DNAzymes for bioimaging, biosensing and cancer therapy
Pei Sun, Hongquan Gou, Xinran Che, Guifang Chen and Chang Feng
Chem. Commun., 2024, 60, 10805
DOI: 10.1039/D4CC03774J

A DNAzymes-in-droplets assay for Burkholderia gladioli pathovar cocovenenans with single-bacterium sensitivity
Xiaoqian Li, Yangyang Chang, Yunping Wu and Meng Liu
Chem. Sci., 2024, 15, 2996
DOI: 10.1039/D3SC05874C

A DNA tetrahedron dimer for dual membrane protein logic recognition and interaction inhibition
Yuanmeng Zhang, Muyang Lin, Jingkang Yao and Xiaowen Xu
Chem. Commun., 2024, 60, 3721
DOI: 10.1039/D4CC00479E

A visual protocol for sensitive Vibrio parahaemolyticus detection based on hybridization chain reaction cascaded DNAzyme
Jiali Wang, Qian Cui, Shu Zeng, Danfeng Fu, Daoyun Peng, Fei Chen, Yi Wan and Anwei Wang
Anal. Methods, 2026, 18, 1433
DOI: 10.1039/D5AY02046H

Amplification-free detection of Escherichia coli using an acidic deoxyribozyme-based paper device
Guangxiao Zhang, Yunping Wu, Wei Xue, Dong Wang, Yangyang Chang and Meng Liu
Chem. Commun., 2024, 60, 6741
DOI: 10.1039/D4CC01150C

In vitro selection of N1-methyladenosine-sensitive RNA-cleaving deoxyribozymes with 105-fold selectivity over unmethylated RNA
Jiarong Shi, Qiang Zhang, Yunping Wu, Yangyang Chang and Meng Liu
Chem. Sci., 2024, 15, 13452
DOI: 10.1039/D4SC02943G

A high-fidelity DNAzyme-assisted CRISPR/Cas13a system with single-nucleotide resolved specificity
Yunping Wu, Ruigang Jin, Yangyang Chang and Meng Liu
Chem. Sci., 2024, 15, 6934
DOI: 10.1039/D4SC01501K

A self-catabolic smart DNAzyme nanocapsule for amplified chemo-photodynamic therapy
Rencun Liu, Yuanyuan Wang, Chen Wu, Weicai Wang and Xuemei Li
J. Mater. Chem. B, 2025, 13, 5334
DOI: 10.1039/D4TB02608J

Recent advances and challenges in developing electrochemiluminescence biosensors for health analysis
Yuxi Wei, Honglan Qi and Chengxiao Zhang
Chem. Commun., 2023, 59, 3507
DOI: 10.1039/D2CC06930J

Acidic in vitro selection of metal-specific deoxyribozymes
Pan Jia, Yangyang Chang, Shen Li, Wei Xue, Shusen Xiao, Qiang Zhang, Jiuxing Li, Ying Wang, Zijie Zhang and Meng Liu
Chem. Sci., 2026, 17, 5554
DOI: 10.1039/D5SC08656F

A DNAzyme amplifier-based immunoassay for small molecule detection
Han Pang and Qiang Zhao
Analyst, 2026, 151, 174
DOI: 10.1039/D5AN01013F

RNA-cleaving DNAzymes for accurate biosensing and gene therapy
Xin Gao, Yixin Liu, Wendi Huo, Yuwei Song, Yu Chen, Jinchao Zhang, Xinjian Yang, Yi Jin and Xing-jie Liang
Nanoscale, 2023, 15, 11346
DOI: 10.1039/D3NR01482G

Self-assembled DNAzyme based on the nicking enzyme amplification reaction for microRNA detection
Hao Zhong, Xin Huang, Ganghui Chen, Ting Zhang, Dongsheng Mao, Zhenyu Lin and Fang Zhang
Anal. Methods, 2025, 17, 7026
DOI: 10.1039/D5AY01000D

CuII-mediated stabilisation of DNA duplexes bearing consecutive ethenoadenine lesions and its application to a metal-responsive DNAzyme
Silpa Chandran Rajasree, Yusuke Takezawa and Mitsuhiko Shionoya
Chem. Commun., 2023, 59, 1006
DOI: 10.1039/D2CC06179A

Single bacteria detection by droplet DNAzyme-coupled rolling circle amplification
Yanchen Chi, Meng Shi, Yanfang Wu, Yunping Wu, Yangyang Chang and Meng Liu
Anal. Methods, 2022, 14, 2244
DOI: 10.1039/D2AY00656A

Advancing environmental safety and public health: a comprehensive review of luminescent probes for radioactive element detection
Yang Pei, Lei Fang, Jiaqi Zhang, Zixun Wang, Linhao Zheng, Yuxuan Zhang, Jiayuan Zhu, Ziyu Wang, Chi Zhang and Jian-Bin Pan
Analyst, 2025, 150, 4252
DOI: 10.1039/D5AN00683J

Self-assembly of protein–DNA superstructures for alkaline phosphatase detection in blood
Yangyang Chang, Qian Zhang, Wei Xue, Yanfang Wu, Yi Liu and Meng Liu
Chem. Commun., 2023, 59, 3399
DOI: 10.1039/D3CC00228D

Protein-targeted aptamers in liquid biopsy: from efficient screening to precise cancer diagnosis
Wenjuan Xu, Qingyang Liu, Na Sun, Tian Gao and Renjun Pei
Analyst, 2026, 151, 275
DOI: 10.1039/D5AN00864F

Functional nucleic acid biosensors utilizing rolling circle amplification
Roger M. Bialy, Alexa Mainguy, Yingfu Li and John D. Brennan
Chem. Soc. Rev., 2022, 51, 9009
DOI: 10.1039/D2CS00613H

Two-layer cascaded catalytic hairpin assemblies based on locked nucleic acids for one-step and highly sensitive ctDNA detection
Kaiyue Tan, Longsheng Chen, Donglin Cao, Wei Xiao, Qian Lv and Lili Zou
Anal. Methods, 2024, 16, 3515
DOI: 10.1039/D4AY00611A

DNA-mediated precise regulation of SERS hotspots for biosensing and bioimaging
Jingjing Zhang, Chunyuan Song, Xiyu He, Jian Liu, Jie Chao and Lianhui Wang
Chem. Soc. Rev., 2025, 54, 5836
DOI: 10.1039/D5CS00124B

Dual stimuli-responsive upconversion nanoparticle–poly-N-isopropylacrylamide/DNA core–shell microgels
Qi Gao, Xiaowen Wang, Shanjin Hu, Ping-Ping He, Siyu Gou, Shuo Liu, Xiaoxue Du and Weiwei Guo
Soft Matter, 2024, 20, 4052
DOI: 10.1039/D4SM00258J

Ligase-mediated synthesis of CuII-responsive allosteric DNAzyme with bifacial 5-carboxyuracil nucleobases
Yusuke Takezawa, Hanci Zhang, Keita Mori, Lingyun Hu and Mitsuhiko Shionoya
Chem. Sci., 2024, 15, 2365
DOI: 10.1039/D3SC05042D

Self-constrained DNAzyme for aptamer-based and sensitive label-free fluorescent assay of sarafloxacin via signal amplification cascades
Qianying Wang, Junyi Zhang, Ruo Yuan and Yun Xiang
Analyst, 2023, 148, 2459
DOI: 10.1039/D3AN00476G

Host–guest recognition-mediated reversible and orthogonal regulation of DNAzyme activity
Lin Xiao, Haitao Zhu, Yanmei Gao and Liang Xu
Chem. Commun., 2025, 61, 1890
DOI: 10.1039/D4CC05330C

Detection of intracellular microRNA-21 for cancer diagnosis by a nanosystem containing a ZnO@polydopamine and DNAzyme probe
Yuanyuan Liu, Ranran Wang, Fengxia Zhang, Yongshan Ma and Tianyi Jiang
RSC Adv., 2024, 14, 13351
DOI: 10.1039/D4RA00636D

Rapid binary visual detection of oxalate in urine samples of urolithiasis patients via competitive recognition and distance reading test strips
Piaopiao Chen, Lihang Cen, Yue Wang, Yunjin Bai, Tian Shi and Xianhua Chen
J. Mater. Chem. B, 2023, 11, 2530
DOI: 10.1039/D2TB02666J

Metal-dependent activity control of a compact-sized 8–17 DNAzyme based on metal-mediated unnatural base pairing
Yusuke Takezawa, Lingyun Hu, Takahiro Nakama and Mitsuhiko Shionoya
Chem. Commun., 2024, 60, 288
DOI: 10.1039/D3CC05520E

Autocatalytic DNA circuitries
Qiong Wu, Wei Xu, Jinhua Shang, Jiajing Li, Xiaoqing Liu, Fuan Wang and Jinghong Li
Chem. Soc. Rev., 2024, 53, 10878
DOI: 10.1039/D4CS00046C

Highly accelerated isothermal nucleic acid amplifications by butanol dehydration: simple, more efficient, and ultrasensitive
Li-Min Zhang, Qing-Xin Gao, Bao-Ping Xie, Jun Chen and Wen-Jun Duan
Chem. Commun., 2022, 58, 5793
DOI: 10.1039/D2CC01589G

DNAzyme-based kinetic regulators enable stimulus-responsive and programmable time delays in DNA strand displacement
Junlan Liu and Yuan Gao
Chem. Commun., 2025, 61, 19857
DOI: 10.1039/D5CC05511C

Protection of DNA by metal ions at 95 °C: from lower critical solution temperature (LCST) behavior to coordination-driven self-assembly
Chang Lu, Yuancong Xu, Po-Jung Jimmy Huang, Mohamad Zandieh, Yihao Wang, Jinkai Zheng and Juewen Liu
Nanoscale, 2022, 14, 14613
DOI: 10.1039/D2NR03461A

DNAzyme recognition triggered cascade signal amplification for rapid and highly sensitive visual detection of uranyl ions
Ling Zhang, Siwei Shi, Penghui Xiong, Lumin Chen, Jie Xu, Jiaolai Jiang, Shanli Yang and Haoxi Wu
Analyst, 2022, 147, 4158
DOI: 10.1039/D2AN01038K

Tunable metal–organic frameworks assist in catalyzing DNAzymes with amplification platforms for biomedical applications
Xiaoguang Zhu, Jiaqi Xu, Guixia Ling and Peng Zhang
Chem. Soc. Rev., 2023, 52, 7549
DOI: 10.1039/D3CS00386H

Fusing Allosteric Ribozymes with CRISPR‐Cas12a for Efficient Diagnostics of Small Molecule Targets
Lichuan Guo, Shu Zhang, Xinyu Du, Mo Zhou and Hongzhou Gu
Small Methods, 2025, 9
DOI: 10.1002/smtd.202401236

Metal Ion‐Mediated Optical Biosensors with Signal Amplification: Recent Advances
Lin Jiang, Chao Wang, Lijun Xu and Renjun Pei
Analysis & Sensing, 2024, 4
DOI: 10.1002/anse.202400014

Cleaving Folded RNA with DNAzyme Agents
Daria D. Nedorezova, Mikhail V. Dubovichenko, Arseniy J. Kalnin, Moustapha A. Y. Nour, Ahmed A. Eldeeb, Anna I. Ashmarova, Gabdulla F. Kurbanov and Dmitry M. Kolpashchikov
ChemBioChem, 2024, 25
DOI: 10.1002/cbic.202300637

Electrodes functionalized with advanced recognition materials for trace electrochemical sensing of uranyl ion
Xian Tang, Hai Han, Le Li and Hongqing Wang
Microchemical Journal, 2024, 199, 109924
DOI: 10.1016/j.microc.2024.109924

Chemically Inducible DNAzyme Sensor for Controllable Imaging of Metal Ions
Rong Wang, Lanxing Yu, Wenhan He, Zhenkun Wu and Jian-Hui Jiang
Anal. Chem., 2024, 96, 1268
DOI: 10.1021/acs.analchem.3c04523

G‐Quadruplex‐Programmed Versatile Nanorobot Combined with Chemotherapy and Gene Therapy for Synergistic Targeted Therapy
Qiwei Wang, Yi Du, Jiao Zheng, Lili Shi and Tao Li
Small, 2024, 20
DOI: 10.1002/smll.202400267

Smartphone-Assisted Flexible Electrochemical Sensor Platform by a Homology DNA Nanomanager Tailored for Multiple Cancer Markers Field Inspection
Jing Xu, Yinbing Liu, Yujin Li, Yilin Liu and Ke-Jing Huang
Anal. Chem., 2023, 95, 13305
DOI: 10.1021/acs.analchem.3c02481

A two-color fluorescence sensing strategy based on functionalized tetrahedral DNAzyme nanotweezers for ochratoxin A detection
Yingao Yang, Ruipeng Chen, Yifen Guo, Jiaxin Zhang, Shuyue Ren, Huanying Zhou and Zhixian Gao
Talanta, 2025, 285, 127348
DOI: 10.1016/j.talanta.2024.127348

Luminescent Lanthanide Probes for Inorganic and Organic Phosphates
Thibaut L. M. Martinon and Valérie C. Pierre
Chemistry — An Asian Journal, 2022, 17
DOI: 10.1002/asia.202200495

A Lateral Flow Test for Staphylococcus aureus in Nasal Mucus Using a New DNAzyme as the Recognition Element
M. Monsur Ali, Ryan Silva, Dawn White, Saeed Mohammadi, Yingfu Li, Alfredo Capretta and John D. Brennan
Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202112346

Csm6-DNAzyme Tandem Assay for One-Pot and Sensitive Analysis of Lead Pollution and Bioaccumulation in Mice
Hao Yang, Feng Li, Ting Xue, Mohammad Rizwan Khan, Xuhan Xia, Rosa Busquets, Hong Gao, Yi Dong, Wenhu Zhou and Ruijie Deng
Anal. Chem., 2022, 94, 16953
DOI: 10.1021/acs.analchem.2c04589

Ce6-DNAzyme-Loaded Metal–Organic Framework Theranostic Agents for Boosting miRNA Imaging-Guided Photodynamic Therapy in Breast Cancer
Zeping Yang, Renpan Qin, Deqiang Ruan, Chong Hu, Wenjing Li, Jie Zhou, Fan Zhang, Bin Guo, Liyu Huang, Daniel Jaque, Yingli Shen and Fu Wang
ACS Nano, 2025, 19, 27873
DOI: 10.1021/acsnano.5c09287

Detecting Legionella pneumophila in Cooling Tower Water Samples with a DNAzyme/Bead‐Based Fluorescence Assay
Shuwen Qian, Erin M. McConnell, Meghan Rothenbroker, Jimmy Gu, Simina Alungulesa, Louis Godbout and Yingfu Li
Analysis & Sensing, 2023, 3
DOI: 10.1002/anse.202300020

Fast Transport and Transformation of Biomacromolecular Substances via Thermo‐Stimulated Active “Inhalation–Exhalation” Cycles of Hierarchically Structured Smart pNIPAM–DNA Hydrogels
Xiaoxue Du, Ping‐Ping He, Chunyan Wang, Xiaowen Wang, Yali Mu and Weiwei Guo
Advanced Materials, 2023, 35
DOI: 10.1002/adma.202206302

Stimuli‐Responsive RNA‐Cleaving DNAzyme for Biomedical Application
Siyuan Wang, Yaqi Liu, Jinhua Shang, Huimin Wang, Changying Yang, Xiaoqing Liu and Fuan Wang
Analysis & Sensing, 2023, 3
DOI: 10.1002/anse.202200065

Advancements in DNAzyme-based biosensors for the detection of hazardous substances in foodstuff: current applications and future perspectives
Taolin Li, Yijia Zhang, Weiwei Cheng, Tiantian Wang, Shuai Hou, Siqi Zhao, Leiqing Pan, Min Chen, Chao Ding and Qiang Liu
Critical Reviews in Food Science and Nutrition, 2025, 65, 7903
DOI: 10.1080/10408398.2025.2486268

DNA nanohydrogel and Pb2 + -specific recognition enable one-pot electrochemical exosome aptasensor for staging of breast cancer
Xiangyue Meng, Xin Zhao, Weijing Liu, Yue Wang, Jie Chen, Kai Chang and Piaopiao Chen
Nano Today, 2025, 65, 102854
DOI: 10.1016/j.nantod.2025.102854

DNA nanocage confined DNAzyme for detection of lead ions coupled with CRISPR-Cas12a system
Ying Yu, Yuan Zhang, Wenhui Li, Zhengwu Wang and Juan Zhang
Chemical Engineering Journal, 2024, 480, 148177
DOI: 10.1016/j.cej.2023.148177

Multiple signal amplification and selective recognition reactions-assisted homogeneous binary visual aptasensor of tuberculosis interferon γ in clinical samples
Piaopiao Chen, Mei Li, Wu Peng, Tangyuheng Liu, Jin Huang and Binwu Ying
Sensors and Actuators B: Chemical, 2023, 376, 132997
DOI: 10.1016/j.snb.2022.132997

DNA-scaffolded catalysis
Jeffrey D. Martell, Edward B. Pimentel, Ashley N. Ogorek, Ethan M. Hartman and Caleb A. Cox
Trends in Chemistry, 2025, 7, 900
DOI: 10.1016/j.trechm.2025.10.001

Inactivation Kinetics of G‐Quadruplex/Hemin Complex and Optimization for More Reliable Catalysis
Anthony R. Monte Carlo and Jinglin Fu
ChemPlusChem, 2022, 87
DOI: 10.1002/cplu.202200090

Simple and sensitive detection of Pseudomonas aeruginosa in neonatal infection based on a both-end blocked peroxidase-mimicking DNAzyme
Dongyun Chen, Yicong Pan, Huan Yu and Xiaoxiang Chen
BioTechniques, 2024, 76, 323
DOI: 10.1080/07366205.2024.2348295

Novel DNA nanoflower biosensing technologies towards next-generation molecular diagnostics
Jing Sheng, Yan Pi, Shuang Zhao, Binpan Wang, Ming Chen and Kai Chang
Trends in Biotechnology, 2023, 41, 653
DOI: 10.1016/j.tibtech.2022.08.011

A Smart Deoxyribozyme‐Programmable Catalytic DNA Circuit for High‐Contrast MicroRNA Imaging
Yuqiu He, Qing Wang, Chen Hong, Ruomeng Li, Jinhua Shang, Shanshan Yu, Xiaoqing Liu and Fuan Wang
Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202307418

Electrochemiluminescence chemical and biosensing methods
Honglan Qi, Yan Li and Chengxiao Zhang
Sci. Sin.-Chim, 2024, 54, 1670
DOI: 10.1360/SSC-2024-0129

Nicked RCA-assisted self-assembling MNAzyme coupled with fluorogenic aptamer for label-free detection of miRNA
Xiang Li, Meng-mei Lv, Hao Liu, Yin-Gang Nie and Zhan-Ming Ying
Sensors and Actuators B: Chemical, 2025, 429, 137278
DOI: 10.1016/j.snb.2025.137278

DNA tetrahedron-supported DNA walker for subtype-specific analysis of extracellular vesicles
Jingjing Xu, Zhikai Fang, Kai Ni, Lijuan Li, Ya Cao, Hongwei Yang and Jing Zhao
Chemical Engineering Journal, 2026, 529, 173226
DOI: 10.1016/j.cej.2026.173226

Fluorescence Aptasensor of Tuberculosis Interferon-γ in Clinical Samples Regulated by Steric Hindrance and Selective Identification
Piaopiao Chen, Wu Peng, Runlian Qu, Yaqin He, Tangyuheng Liu, Jin Huang and Binwu Ying
Anal. Chem., 2022, 94, 9122
DOI: 10.1021/acs.analchem.2c01530

Metal-based biomaterials for cancer gene therapy
Silu Li, Chen Zhang, Xinan Xu, Xiaojie Wang, He Ren, Boyang Sun and Yumiao Zhang
Coordination Chemistry Reviews, 2025, 538, 216720
DOI: 10.1016/j.ccr.2025.216720

Construction of a Functional Nucleic Acid-Based Artificial Vesicle-Encapsulated Composite Nanoparticle and Its Application in Retinoblastoma-Targeted Theranostics
Xueqi Hu, Dongdong Zhang, Linjie Huang, Zheng Zeng, Yina Su, Shanshan Chen, Xiahui Lin and Shanni Hong
ACS Biomater. Sci. Eng., 2024, 10, 1830
DOI: 10.1021/acsbiomaterials.3c01972

Tetrad metal ion mediated molecular switch aptamer sensor for fluorescence assay of plasma IP-10 in clinical tuberculosis
Tian Shi, Pengjun Jiang, Yue Wang, Yi Xie, Binwu Ying and Piaopiao Chen
Sensors and Actuators B: Chemical, 2024, 410, 135699
DOI: 10.1016/j.snb.2024.135699

Recent advances in DNA nanomaterials for cancer diagnosis and treatment
Longjie Li, Zhen Wang, Xuehao Zhang, Yukai Deng, Yaoqin Mu, Jingrou Li, Li-mei Wang, Hong-xun Wang, Junlin Zhang, Hengyi Gao and Yajie Mao
Nanotechnology Reviews, 2023, 12
DOI: 10.1515/ntrev-2023-0135

DNAzyme-based sensing tools
Shan Huang, Xinyi Jing, Jin Shao, Xiaoming Ren and Xiaojun Chen
Chinese Chemical Letters, 2026, 112451
DOI: 10.1016/j.cclet.2026.112451

A DNAzyme-based biosensor enables APE1 detection with ligand-induced self-assembled Cu nanoclusters as enhanced near-infrared electrochemiluminescence emitters
Haonan He, Shuang Li, Hejun Gao, Hongquan Fu, Yunwen Liao and Juan Zhang
Microchemical Journal, 2026, 222, 117221
DOI: 10.1016/j.microc.2026.117221

Antibody-Bridged DNAzyme Walker for Sensitive Detection of Small Molecules
Han Pang and Qiang Zhao
Anal. Chem., 2024, 96, 6366
DOI: 10.1021/acs.analchem.4c00250

Microenvironment-activated DNA nanomachine for self-circulating amplified RNA imaging and closed-loop fueled synergistic therapy in cancer cell
Xin Chen, Hongyu Qian, Shixin Cai, Xiaoli Wang, Yuting Zhang and Nandi Zhou
Sensors and Actuators B: Chemical, 2026, 453, 139516
DOI: 10.1016/j.snb.2026.139516

A biodegradable and cofactor self-sufficient aptazyme nanoprobe for amplified imaging of low-abundance protein in living cells
Jiayao Xu, Lifang Yao, Xiaohong Zhong, Kun Hu, Shulin Zhao and Yong Huang
Talanta, 2023, 253, 123983
DOI: 10.1016/j.talanta.2022.123983

Design of a Membrane-Anchored DNAzyme-Based Molecular Machine for Enhanced Cancer Therapy by Customized Cascade Regulation
Man-Sha Wu, Ze-Rui Zhou, Xiao-Yuan Wang, Xi-Chen Du, Da-Wei Li and Ruo-Can Qian
ACS Pharmacol. Transl. Sci., 2024, 7, 2869
DOI: 10.1021/acsptsci.4c00362

Amplification-free one-pot RNA detection by pairing CRISPR–Cas13a with cascade amplification circuit-driven DNAzyme (RAPID)
Xiaona Yin, Ziyan Zhang, Hao Luo, Xiaolin Qin, Yang Chen, Wentao Chen and Heping Zheng
Analytica Chimica Acta, 2026, 1391, 345138
DOI: 10.1016/j.aca.2026.345138

Shattering kinetic constraints: hierarchically activatable DNAzyme nanoantennas for in situ mRNA imaging and precise cancer theranostics
Qian Han, Shi Wang, Li-juan Wang and Chun-yang Zhang
Biosensors and Bioelectronics, 2026, 291, 118016
DOI: 10.1016/j.bios.2025.118016

An RNA‐Cleaving DNAzyme That Requires an Organic Solvent to Function
Tianjun Chang, Guangping Li, Dingran Chang, Ryan Amini, Xiaoni Zhu, Tongqian Zhao, Jimmy Gu, Zhongping Li and Yingfu Li
Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202310941

Integrating synthetic biology and biosensing: Current trends and future prospects
Karuna Korgaonkar, Nagarjuna Prakash Dalbanjan, Maruti J. Gurav, Manjunath P. Eelager, Vishwanath B. Chachadi and S.K. Praveen Kumar
Next Research, 2025, 2, 100911
DOI: 10.1016/j.nexres.2025.100911

CRISPR Assays for Protein Detection
Luca Capelli, Elena Spezzani, Dharshini Raghavan, Chiara Micucci, Alessandra Zanut and Alessandro Bertucci
Chemistry Methods, 2026, 6
DOI: 10.1002/cmtd.202600005

Enzymatically Controlled Nanoflares for Specific Molecular Recognition and Biosensing
Ya Zhao, Jian Zhao, Jingfang Zhang, Yan Sun, Lele Li, Zhengping Li and Mengyuan Li
Anal. Chem., 2022, 94, 8883
DOI: 10.1021/acs.analchem.2c00166

Electrochemical DNAzyme-based biosensors for disease diagnosis
Richa Pandey, Yang Lu, Erin M. McConnell, Enas Osman, Alexander Scott, Jimmy Gu, Todd Hoare, Leyla Soleymani and Yingfu Li
Biosensors and Bioelectronics, 2023, 224, 114983
DOI: 10.1016/j.bios.2022.114983

Peptide-DNA conjugates as building blocks for de novo design of hybrid nanostructures
Mathias Bogetoft Danielsen, Hanbin Mao and Chenguang Lou
Cell Reports Physical Science, 2023, 4, 101620
DOI: 10.1016/j.xcrp.2023.101620

A close-looped DNAzyme walker with an available catalytic domain for electrochemiluminescent detection of acetamiprid
Lidan Zhao, Meiling Zhao, Xuemei Zhou, Ruo Yuan, Xia Zhong and Ying Zhuo
Food Chemistry, 2024, 458, 140202
DOI: 10.1016/j.foodchem.2024.140202

Comprehensive approaches to expanding CRISPR biosensor applications beyond nucleic acid targets
Indrani Nandi, Jyoti Verma, Rajendra Prasad, Sumit K. Singh and Pranjal Chandra
TrAC Trends in Analytical Chemistry, 2025, 185, 118179
DOI: 10.1016/j.trac.2025.118179

Advances of functional nucleic acids based on specific recognition:A review
Beibei Liu, Ge Chen, A.M. Abd El-Aty, Rongqi Zhai, Guangyang Liu, Xiaomin Xu, Yanguo Zhang, Lingyun Li, Jie Zhang and Donghui Xu
International Journal of Biological Macromolecules, 2025, 304, 140828
DOI: 10.1016/j.ijbiomac.2025.140828

Modular Engineering of DNAzyme-Based Sensors for Spatioselective Imaging of Metal Ions in Mitochondria
Deyu Yi, Hengzhi Zhao, Jian Zhao and Lele Li
J. Am. Chem. Soc., 2023, 145, 1678
DOI: 10.1021/jacs.2c11081

Spatial Confinement of a Dual Activatable DNAzyme Sensor in the Cavity of a DNA Nanocage for Logic‐Gated Molecular Imaging
Tingting Tu, Shuangyan Huan, Xueyan Feng, Guoliang Ke, Lele Li and Xiao‐Bing Zhang
Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202424684

Dual-signal fluorescence assay for apolipoprotein E genotyping based on rolling circle amplification-derived DNAzyme cleavage reaction
Xiaolong Yan, Sijia Tang, Xinyao Yi and Jianxiu Wang
Sensors and Actuators B: Chemical, 2026, 456, 139691
DOI: 10.1016/j.snb.2026.139691

Programming a DNA tetrahedral nanomachine as an integrative tool for intracellular microRNA biosensing and stimulus-unlocked target regulation
Lianyu Yu, Sha Yang, Zeyu Liu, Xiaopei Qiu, Xiaoqi Tang, Shuang Zhao, Hanqing Xu, Mingxuan Gao, Jing Bao, Ligai Zhang, Dan Luo, Kai Chang and Ming Chen
Materials Today Bio, 2022, 15, 100276
DOI: 10.1016/j.mtbio.2022.100276

Strategic evolution of catalytic hairpin assembly: Engineering MicroRNA analysis from mechanism to applications
Chao Luo, Ruilin Zuo, Shasha Lu, Gengwu Zhang, Dong Xu and Chunxian Guo
TrAC Trends in Analytical Chemistry, 2026, 199, 118807
DOI: 10.1016/j.trac.2026.118807

Fluorescence-Based Multimodal DNA Logic Gates
Chamika Harshani Algama, Jamil Basir, Kalani M. Wijesinghe and Soma Dhakal
Nanomaterials, 2024, 14, 1185
DOI: 10.3390/nano14141185

Engineered DNA molecular machine for ultrasensitive detection of environmental lead pollution
Hehe Tang, Wei Chang, Huijie Xue, Changlu Xu, Zhi Li, Hao Liu, Chao Xing, Gang Liu, Xiaoyan Liu, Hua Wang and Jie Wang
Journal of Hazardous Materials, 2023, 459, 132306
DOI: 10.1016/j.jhazmat.2023.132306

Recent advances in functional nucleic acid decorated nanomaterials for cancer imaging and therapy
Liu Wu, Ruitao Yuan, Tong Wen, Yingfeng Qin, Yumin Wang, Xiaoling Luo and Jin-Wen Liu
Biomedicine & Pharmacotherapy, 2024, 174, 116546
DOI: 10.1016/j.biopha.2024.116546

Modular Weaving DNAzyme in Skeleton of DNA Nanocages for Photoactivatable Catalytic Activity Regulation
Hengzhi Zhao, Deyu Yi, Lele Li, Yuliang Zhao and Mengyuan Li
Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202404064

DNAzyme biosensor as an emerging food safety indicator: History and fundamental mechanism to future prospects
You Zhou, Sobia Niazi, Muhammad Kashif Iqbal Khan, Faizan ul Haq, Ali Raza, Khubaib Ali, Ali Mohsin, Muhammad Shoaib, Muhammad Sajjad, Ibrahim Khan, Fatima Jerosha, Shahid Iqbal, Tehmina Azam, Zhouping Wang and Imran Mahmood Khan
TrAC Trends in Analytical Chemistry, 2026, 194, 118516
DOI: 10.1016/j.trac.2025.118516

Label-free colorimetric biosensor for sensitive detection of lead (II) ion based on aptazyme-amplified oxidase-like activity of MnO2 nanoflowers
Fatemeh Mohammadi, Zahra Khoshbin, Samad Ahadian, Peyman Asadi, Mohammad Ramezani, Mona Alibolandi, Khalil Abnous and Seyed Mohammad Taghdisi
Biosensors and Bioelectronics, 2025, 287, 117751
DOI: 10.1016/j.bios.2025.117751

PCR‐Free Site‐Directed Mutagenesis on Repetitive Sequences Using Single‐Stranded DNA‐Assisted Double‐Stranded DNA Nicking by DNAzymes
Mingkuan Lyu, Linggen Kong, Xiangli Shao and Yi Lu
Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202509127

Cascaded and autocatalytic nucleic acid circuit for exponentially amplified and aptamer-based ultrasensitive fluorescent biosensing of sarcosine cancer biomarker
Linjie Yuan, Xiaoju Liu, Huaifeng Yan, Bingying Jiang, Ruo Yuan and Yun Xiang
Sensors and Actuators B: Chemical, 2025, 426, 137130
DOI: 10.1016/j.snb.2024.137130

Spherical Nucleic Acids as Modulators of CRISPR/Cas12a by a Steric Barrier Effect for Designing Versatile Biosensors
Fengxi Zhu and Qiang Zhao
Anal. Chem., 2025, 97, 12215
DOI: 10.1021/acs.analchem.5c00937

An ultrasensitive Cd2+ detection biosensor based on DNAzyme and CRISPR/Cas12a coupled with hybridization chain reaction
Pengda Liang, Bei Lv, Ke Chen, Wenrui Qiao and Dawei Li
Analytica Chimica Acta, 2023, 1283, 341950
DOI: 10.1016/j.aca.2023.341950

Recent Advances in DNA Systems for In Situ Telomerase Activity Detection and Imaging
Shiyi Zhang, Wenjing Xiong, Shuyue Xu and Ruocan Qian
Chemosensors, 2025, 13, 17
DOI: 10.3390/chemosensors13010017

Bioinspired Nucleic Acid-Based Bandpass Filters and Their Concentration-Adaptive Functions
Si Chen, Weijun Shu, Shan Wang, Liang Yue and Weihong Tan
J. Am. Chem. Soc., 2025, 147, 12786
DOI: 10.1021/jacs.5c01331

Development of Nucleic‐Acid‐Based Electrochemical Biosensors for Clinical Applications
Zijie Zhang, Payel Sen, Bal Ram Adhikari, Yingfu Li and Leyla Soleymani
Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202212496

Functional porous material-based sensors for food safety
Yanan Lei, Jie Cheng, Huanli Dong and Peilong Wang
Coordination Chemistry Reviews, 2024, 501, 215566
DOI: 10.1016/j.ccr.2023.215566

Endogenous Enzyme-Driven Amplified DNA Nanocage Probe for Selective and Sensitive Imaging of Mature MicroRNAs in Living Cancer Cells
Yingying Gao, Chaonan Gong, Mei Chen, Shuangyan Huan, Xiao-Bing Zhang and Guoliang Ke
Anal. Chem., 2024, 96, 9453
DOI: 10.1021/acs.analchem.4c00704

Magnetic separation-based DNAzyme-induced EXPAR for highly sensitive and rapid analysis of Pb²⁺
Junfeng Peng, Jing Peng, Rongjing Wang, Xinyu Tan, Yaoyun Liang, Ziyue Qiu, Luyin Zhang, Bin Sun, Huihui Yang, Lang Zhang, Zong Dai and Jun Chen
Sensors and Actuators B: Chemical, 2026, 447, 138787
DOI: 10.1016/j.snb.2025.138787

Chemical and structural modification of RNA-cleaving DNAzymes for efficient biosensing and biomedical applications
Qing Wang, Zeyue Wang, Yuqiu He, Bin Xiong, Yingfu Li and Fuan Wang
TrAC Trends in Analytical Chemistry, 2023, 159, 116910
DOI: 10.1016/j.trac.2022.116910

Dynamic DNA Circuits for Biomedical Applications
Xinghua Chen, Zhixin Zhou, Eli Pikarsky and Itamar Willner
ACS Nano Med., 2026
DOI: 10.1021/acsnanomed.5c00176

A target-triggered colorimetric sensor for ultrasensitive detection of miRNAs based on self-powered three-dimensional DNA walker
Yingxue Li, Tingrui Zhang, Gang Bai, Mengchun Chen, Xiaodong Lei, Li Ye, Hua Yu, Zhichao Fan and Tao Yu
International Journal of Biological Macromolecules, 2024, 279, 135370
DOI: 10.1016/j.ijbiomac.2024.135370

Self-powered DNA nanomachines for fluorescence detection of lead
Xiang-Ling Li, Han Jiang, Lei Zhao, Tian shun Song and Jing jing Xie
Microchim Acta, 2023, 190
DOI: 10.1007/s00604-023-05673-7

A protein enzyme-free strategy for fluorescence detection of single nucleotide polymorphisms using asymmetric MNAzymes
Xuanhao Zhang, Qian Li, Qiqi Chao, Yuxi Zhang, Xufeng Sun, Gao-Chao Fan, Zhi-Ling Song, Rongmei Kong and Xiliang Luo
Analytica Chimica Acta, 2023, 1243, 340811
DOI: 10.1016/j.aca.2023.340811

A sodium-dependent split DNAzyme fluorescent sensor under butanol acceleration for ultrasensitive detection of PIWI-interacting RNAs and microRNAs
Qing-Xin Gao, Li-Min Zhang, Qian-Qian Wu, Fang-Fang Guo, Jun Chen, Min-Min Li, Yong-Yi Wu, Bao-Ping Xie and Wen-Jun Duan
Sensors and Actuators B: Chemical, 2023, 393, 134272
DOI: 10.1016/j.snb.2023.134272

Gene Therapy Drugs Based on Synthetic Oligonucleotides
I. B. Kozlov, O. A. Gerasimov, O. Y. Domasheva, L. G. Bushina, L. A. Safonova, V. V. Makarov and V. S. Yudin
Russ J Bioorg Chem, 2025, 51, 491
DOI: 10.1134/S1068162024605986

A Programmable DNAzyme for the Sensitive Detection of Nucleic Acids
Chenzhi Shi, Donglei Yang, Xiaowei Ma, Li Pan, Yuanchuan Shao, Gaurav Arya, Yonggang Ke, Chuan Zhang, Fuan Wang, Xiaolei Zuo, Min Li and Pengfei Wang
Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202320179

Synthesis and application of zeolitic imidazolate frameworks-based nucleic acid delivery system in tumor diagnosis and therapy: a review
Liping Wang, Zhijuan Liang, Dan Li, Yuanbin Chen, Guofeng Ma and Ye Liang
Biomed. Mater., 2023, 18, 052002
DOI: 10.1088/1748-605X/ace39d

Artificial Intelligence in Point-of-Care Biosensing: Challenges and Opportunities
Connor D. Flynn and Dingran Chang
Diagnostics, 2024, 14, 1100
DOI: 10.3390/diagnostics14111100

A Fluorogenic DNAzyme for A Thermally Stable Protein Biomarker from Fusobacterium nucleatum, a Human Bacterial Pathogen
Qian Feng, Sandy Zakaria, Devon Morrison, Kha Tram, Jim Gu, Bruno J. Salena and Yingfu Li
Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202306272

Progress in Hybridization Chain Reaction-Based Photoelectrochemical Biosensors
Yunxiao Feng, Hao Xie and Binbin Zhou
International Journal of Electrochemical Science, 2022, 17, 220641
DOI: 10.20964/2022.06.18

A Rapid Sputum‐based Lateral Flow Assay for Airway Eosinophilia using an RNA‐cleaving DNAzyme Selected for Eosinophil Peroxidase
M. Monsur Ali, Manali Mukherjee, Katherine Radford, Zil Patel, Alfredo Capretta, Parameswaran Nair and John D. Brennan
Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202307451

Proximity‐Dependent Activation of Split DNAzyme Kinase
Jiayi Wang, Yangyang Chang and Meng Liu
ChemBioChem, 2024, 25
DOI: 10.1002/cbic.202400368

Cascaded and autocatalytic dumbbell probe for exponentially amplified and label-free highly-sensitive fluorescent biosensing of miRNA from cancer cells
Min Zhong, Nianting Xiao, Yaqin Tang, Yu Liu, Xiao Guo, Chunyuan Gan, Wenli Wu, Lian Yi and Daxiu Li
Sensors and Actuators Reports, 2026, 11, 100434
DOI: 10.1016/j.snr.2026.100434

Pushing Adenosine and ATP SELEX for DNA Aptamers with Nanomolar Affinity
Yuzhe Ding and Juewen Liu
J. Am. Chem. Soc., 2023, 145, 7540
DOI: 10.1021/jacs.3c00848

Application of Lateral Flow Biosensors in Rapid Detection of Genetically Modified Products
Zihe Li, Yanlai Liu, Yuancong Xu and Nan Cheng
J. Anal. Test., 2026, 10, 102
DOI: 10.1007/s41664-025-00377-8

Simultaneous Fe 2+ /Fe 3+ imaging shows Fe 3+ over Fe 2+ enrichment in Alzheimer’s disease mouse brain
Yuting Wu, Seyed-Fakhreddin Torabi, Ryan J. Lake, Shanni Hong, Zhengxin Yu, Peiwen Wu, Zhenglin Yang, Kevin Nelson, Weijie Guo, Gregory T. Pawel, Jacqueline Van Stappen, Xiangli Shao, Liviu M. Mirica and Yi Lu
Sci. Adv., 2023, 9
DOI: 10.1126/sciadv.ade7622

Highly sensitive detection of the tetracycline resistance gene tetA in water supply systems with an autocatalytic deoxyribonucleic acid–based cascade circuit
RuJie Wang, Yu Zhou, WeiYing Li, HuaJie Liu, Qing Lu and WenHai Chu
Journal of Hazardous Materials, 2025, 492, 138226
DOI: 10.1016/j.jhazmat.2025.138226

Biosensor-based methods for exosome detection with applications to disease diagnosis
Weikang Ge, Zheying Mu, Shiao Yang, Yujing Zeng, Ying Deng, Yifan Lin, Ping Xie and Genxi Li
Biosensors and Bioelectronics, 2025, 279, 117362
DOI: 10.1016/j.bios.2025.117362

Progress in biosensing applications of isothermal nucleic acid amplification techniques
Chaocheng Feng, Yuan Liao, Jinxuan Jia, Lexiang Zhang and Yongxiang Zhao
Microchemical Journal, 2025, 214, 113919
DOI: 10.1016/j.microc.2025.113919

A Lateral Flow Test for Staphylococcus aureus in Nasal Mucus Using a New DNAzyme as the Recognition Element
M. Monsur Ali, Ryan Silva, Dawn White, Saeed Mohammadi, Yingfu Li, Alfredo Capretta and John D. Brennan
Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202112346

A fluorescent biosensor for Cd2+ detection in water samples based on Cd2+-fueled wheel DNAzyme walker and its logic gate applications
Jiafeng Pan, Fang Deng and Junhua Chen
Science of The Total Environment, 2023, 864, 161046
DOI: 10.1016/j.scitotenv.2022.161046

RNA‐Cleaving DNAzyme‐Based Amplification Strategies for Biosensing and Therapy
Jiaxin Su, Chenyang Sun, Jinya Du, Xiaotong Xing, Fang Wang and Haifeng Dong
Adv Healthcare Materials, 2023, 12
DOI: 10.1002/adhm.202300367

Dynamic DNA nanomachines for amplification imaging of diseased cells based on stimuli-responsive mechanism
Jingting Wu, Wenqing Lin and Zai-Sheng Wu
Advanced Agrochem, 2023, 2, 202
DOI: 10.1016/j.aac.2023.06.001

CRISPR/Cas system for real-time water quality monitoring: Advances and challenges
Meiru Liu, Zena Huang, Yan Lin, Yanyan Li, Weixue Xu, Yao Lu, Sicheng Cui, Tenghua Zhang, Yan Sheng and Jiaming Hu
TrAC Trends in Analytical Chemistry, 2026, 198, 118773
DOI: 10.1016/j.trac.2026.118773

Fluorescence biosensor for ultrasensitive detection of the available lead based on target biorecognition-induced DNA cyclic assembly
Junhua Chen, Manjia Chen, Hui Tong, Fei Wu, Yizhang Liu and Chengshuai Liu
Science of The Total Environment, 2023, 905, 167253
DOI: 10.1016/j.scitotenv.2023.167253

State-of-the-art strategies of surface plasmon resonance biosensors in clinical analysis: A comprehensive review
Jie Zhou, Yue Wang and Guo-Jun Zhang
Coordination Chemistry Reviews, 2024, 520, 216149
DOI: 10.1016/j.ccr.2024.216149

Recent Advances in DNAzyme Systems for Disease Diagnosis and Therapy
Hongbo Zhang and Qubo Zhu
Adv Healthcare Materials, 2026, 15
DOI: 10.1002/adhm.202504385

DNA functionalized plasmonic nanoassemblies as SERS sensors for environmental analysis
Jinxiang Li, Xueqin Chen and Jun‐Jie Zhu
Aggregate, 2023, 4
DOI: 10.1002/agt2.271

A colorimetric and fluorescent dual-mode sensor based on bifunctional G-quadruplex-hemin complex for the determination of Pb2+
Tai Ye, Haohao Chen, Long Bai, Min Yuan, Hui Cao, Liling Hao, Xiuxiu Wu, Fengqin Yin and Fei Xu
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2024, 309, 123807
DOI: 10.1016/j.saa.2023.123807

Chemoenzymatic Installation of Site-Specific Chemical Groups on DNA Enhances the Catalytic Activity
Ze Zhang, Wanqing Wei, Siqi Chen, Jintao Yang, Dongfan Song, Yinghan Chen, Zerun Zhao, Jiawen Chen, Fulong Wang, Jiahuan Wang, Zhe Li, Yong Liang and Hanyang Yu
J. Am. Chem. Soc., 2024, 146, 7052
DOI: 10.1021/jacs.4c00484

Cerium-vanadium nanozyme/DNAzyme system for rheumatoid arthritis therapy through reactive oxygen species scavenging and inflammation regulation
Youcong Gong, Zijia Zhou, Ming-jie Dong, Huiyu Liu, Jinkun Huang and Haifeng Dong
Cell Biomaterials, 2026, 2, 100190
DOI: 10.1016/j.celbio.2025.100190

Lysosomes Initiating and DNAzyme-Assisted Intracellular Signal Amplification Strategy for Quantification of Alpha-Fetoprotein in a Single Cell
Shengyu Chen, Jingjin Zhao, Chunhuan Xu, Bingfang Shi, Jiayao Xu, Shengqiang Hu and Shulin Zhao
Anal. Chem., 2024, 96, 85
DOI: 10.1021/acs.analchem.3c03152

Development and application of DNA hydrogels in biosensing: Current status and future implications
Zhuo Chen, Kang Mao, Jiaqi Xue, Rida Feng, Kuankuan Zhang, Junxia Su, Wei Du, Jiabing Ran, Changying Yang, Zhugen Yang and Hua Zhang
Microchemical Journal, 2025, 213, 113664
DOI: 10.1016/j.microc.2025.113664

A Smart Deoxyribozyme‐Programmable Catalytic DNA Circuit for High‐Contrast MicroRNA Imaging
Yuqiu He, Qing Wang, Chen Hong, Ruomeng Li, Jinhua Shang, Shanshan Yu, Xiaoqing Liu and Fuan Wang
Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202307418

Arrest of CRISPR-Cas12a by Nonspecific Single-Stranded DNA for Biosensing
Yue Liu, Yunping Wu, Yi Liu, Qiang Zhang, Hong Yuan, Shen Li, Zhi Li, Bo Wang, Yangyang Chang and Meng Liu
Anal. Chem., 2025, 97, 9310
DOI: 10.1021/acs.analchem.4c07081

Biomolecular sensors for advanced physiological monitoring
Connor D. Flynn, Dingran Chang, Alam Mahmud, Hanie Yousefi, Jagotamoy Das, Kimberly T. Riordan, Edward H. Sargent and Shana O. Kelley
Nat Rev Bioeng, 2023, 1, 560
DOI: 10.1038/s44222-023-00067-z

A sensitive tobramycin electrochemical aptasensor based on multiple signal amplification cascades
Yi Zhao, Qirong Chen, Yujie Liu, Bingying Jiang, Ruo Yuan and Yun Xiang
Bioelectrochemistry, 2024, 160, 108797
DOI: 10.1016/j.bioelechem.2024.108797

Personal glucose meters coupled with signal amplification technologies for quantitative detection of non-glucose targets: Recent progress and challenges in food safety hazards analysis
Feng He, Haijie Wang, Pengfei Du, Tengfei Li, Weiting Wang, Tianyu Tan, Yaobo Liu, Yanli Ma, Yuanshang Wang and A.M. Abd El-Aty
Journal of Pharmaceutical Analysis, 2023, 13, 223
DOI: 10.1016/j.jpha.2023.02.005

A promising nucleic acid therapy drug: DNAzymes and its delivery system
Lang Xiao, Yan Zhao, Meng Yang, Guangxin Luan, Ting Du, Shanshan Deng and Xu Jia
Front. Mol. Biosci., 2023, 10
DOI: 10.3389/fmolb.2023.1270101

Recent Development of Copper‐Based Nanozymes for Biomedical Applications
Xin Yu, Yawen Wang, Jian Zhang, Jing Liu, Aizhu Wang and Longhua Ding
Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202302023

Spatially Localized Entropy-Driven Evolution of Nucleic Acid-Based Constitutional Dynamic Networks for Intracellular Imaging and Spatiotemporal Programmable Gene Therapy
Nina Lin, Yu Ouyang, Yunlong Qin, Ola Karmi, Yang Sung Sohn, Songqin Liu, Rachel Nechushtai, Yuanjian Zhang, Itamar Willner and Zhixin Zhou
J. Am. Chem. Soc., 2024, 146, 20685
DOI: 10.1021/jacs.4c03651

Aptamer‐Modified Homogeneous Catalysts, Heterogenous Nanoparticle Catalysts, and Photocatalysts: Functional “Nucleoapzymes”, “Aptananozymes”, and “Photoaptazymes”
Yu Ouyang, Michael P O'Hagan, Bilha Willner and Itamar Willner
Advanced Materials, 2024, 36
DOI: 10.1002/adma.202210885

Cross‐Binding of Adenosine by Aptamers Selected Using Theophylline
Po‐Jung Jimmy Huang, Natasha M. Evans, Chang Lu, Albert Zehan Li, Thorsten Dieckmann and Juewen Liu
ChemBioChem, 2023, 24
DOI: 10.1002/cbic.202300566

Engineering a Near-Infrared Spiro-Based Aggregation-Induced Emission Luminogen for DNAzyme-Sensitized Photothermal Therapy with High Efficiency and Accuracy
Yingying Chen, Sheng-Yi Yang, Xinwen Ou, Hui Wang, Fan-Cheng Kong, Philip C. Y. Chow, Yifei Wang, Yuqian Jiang, Wei Zhao, Jianwei Sun, Ryan T. K. Kwok, Di-Wei Zheng, Wenqian Yu, Fuan Wang, Jacky W. Y. Lam and Ben Zhong Tang
J. Am. Chem. Soc., 2024, 146, 35462
DOI: 10.1021/jacs.4c14818

A novel viral RNA detection method based on the combined use of trans-acting ribozymes and HCR-FRET analyses
Leonardo Ferreira da Silva, Aisel Valle Garay, Pedro Felipe Queiroz, Sophia Garcia de Resende, Mayna Gomide, Izadora Cristina Moreira de Oliveira, Amanda Souza Bernasol, Anibal Arce, Liem Canet Santos, Fernando Torres, Ildinete Silva-Pereira, Sonia Maria de Freitas, Cíntia Marques Coelho and Ruijie Deng
PLoS ONE, 2024, 19, e0310171
DOI: 10.1371/journal.pone.0310171

Hybrid DNA nanomaterial and three-directional hybridization chain reaction enable electrochemical diagnosing metastatic lymph nodes of breast cancer by one-step exosome sensing
Zhihao Zhang, Ronghao Hu, Di Fu, Weijing Liu, Jie Qu, Yue Wang, Xianghu Zeng, Xin Zhao, Xiangyue Meng, Binxu Qiu, Xin Jiang, Bofu Liu, Jie Chen and Piaopiao Chen
Chemical Engineering Journal, 2025, 517, 164315
DOI: 10.1016/j.cej.2025.164315

One-Pot and Enzyme-Free Analysis of mRNA Vaccines Based on a Double Amplification System Featured by Adjustable Structure MNAzyme
Feifan Yin, Murilege Chao, Jinhua Chen, Yanheng Yao, Miao He, Qiufeng Wang, Wenting Cheng, Yongliang Cai, Zhongyun Wang and Yang Xiang
Anal. Chem., 2025, 97, 21134
DOI: 10.1021/acs.analchem.5c04634

Target-responsive DNA translator for amplified and sensitive sensing of Myc-Max transcription factor dimer
Daxiu Li, Yusi Li, Ruo Yuan and Yun Xiang
Sensors and Actuators B: Chemical, 2023, 390, 133949
DOI: 10.1016/j.snb.2023.133949

DNAzyme-Based Point-of-Care Diagnosis of Aggressive Periodontitis
Xia Li, Pan Jia, Shusen Xiao, Zijie Zhang, Dan Xue, Yangyang Chang, Rui Zhang, Qiang Zhang, Shen Li, Rudi Liu, Changfeng Qu, Jiuxing Li and Meng Liu
ACS Sens., 2025, 10, 9077
DOI: 10.1021/acssensors.5c03632

Nanoarchitectonics-Assisted Simultaneous Fluorescence Detection of Urinary Dual miRNAs for Noninvasive Diagnosis of Prostate Cancer
Pengjun Jiang, Yunjin Bai, Li Yan, Pan Feng, Ke Huang, Jie Chen and Piaopiao Chen
Anal. Chem., 2023, 95, 7676
DOI: 10.1021/acs.analchem.3c00701

Recent Progress in DNA Biosensors for Detecting Biomarkers in Living Cells
Zaizai Dong, Rongtai Su, Yao Fu, Yupei Wang and Lingqian Chang
ACS Biomater. Sci. Eng., 2024, 10, 5595
DOI: 10.1021/acsbiomaterials.4c01339

Ultralow background one-pot detection of Lead(II) using a non-enzymatic double-cycle system mediated by a hairpin-involved DNAzyme
Ting Yan, Yuying Hou, Qianqian Zuo, Difei Jiang, Huijie Zhao, Tongyue Xia, Xiaoqian Zhu, Xutiange Han, Ran An and Xingguo Liang
Biosensors and Bioelectronics, 2023, 237, 115534
DOI: 10.1016/j.bios.2023.115534

Single‐atom metal‐nitrogen‐carbon catalysts energize single molecule detection for biosensing
Xianyang Zhang, Pengfei Chen, Siwuxie He, Bowen Jiang, Yong Wang, Yonghua Cheng, Jian Peng, Francis Verpoort, John Wang and Zongkui Kou
InfoMat, 2023, 5
DOI: 10.1002/inf2.12421

Framework Nucleic Acid‐Mediated DNAzyme Chaperoning for Sensitive Trace Metal Ion Mapping on Live Neuronal Cell Membranes
Tianqi Xu, Fan Li, Yichao Jin, Feng Jia, Yu Wang, Tao Lv, Yueyue Zhang, Min Li, Chunhai Fan, Mingqiang Li, Xiaohua Zhang, Shaopeng Wang and Xiaolei Zuo
Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202506640

MXene-Based Nucleic Acid Biosensors for Agricultural and Food Systems
Weizheng Wang and Sundaram Gunasekaran
Biosensors, 2022, 12, 982
DOI: 10.3390/bios12110982

Selection and characterization of a DNA aptamer for Patulin and its application in a label-free fluorescence assay for fruit juices
Sihan Wang, Jiayi Liang, Haiyang Jiang, Jianzhong Shen, Zhanhui Wang and Juewen Liu
One Health Adv., 2025, 3
DOI: 10.1186/s44280-025-00101-2

Nucleic Acid and Nanomaterial Synergistic Amplification Enables Dual Targets of Ultrasensitive Fluorescence Quantification to Improve the Efficacy of Clinical Tuberculosis Diagnosis
Tian Shi, Pengjun Jiang, Wu Peng, Yanming Meng, Binwu Ying and Piaopiao Chen
ACS Appl. Mater. Interfaces, 2024, 16, 14510
DOI: 10.1021/acsami.3c18596

Portable, and ultrasensitive HR-HPV tests based on nucleic acid biosensors
Chang Ma, Minhong Zou, Ning Xu, Yan Liu and Yuru Wang
Front. Cell. Infect. Microbiol., 2024, 14
DOI: 10.3389/fcimb.2024.1357090

Dehybridization-Free and Fluorescent Cleavage-Active DNAzyme by a Catalytic Core-Associative Fluorogen
Jiahui Chen, Qiyao Chen, Qinxin Li, Jiahuan Zhou, Sihui Huang, Dandan Wang, Xiaoshun Zhou and Yong Shao
Anal. Chem., 2025, 97, 16313
DOI: 10.1021/acs.analchem.5c01820

Fluorescent nucleic acid probes for DNA repair enzymes: Design strategies and applications
Xinyu Luan, Xiaoyan Tang, Jiewei Deng, Yunyun Yang, Junqiu Zhai and Tiangang Luan
TrAC Trends in Analytical Chemistry, 2024, 171, 117489
DOI: 10.1016/j.trac.2023.117489

Dual-signal-amplified nanopore sensor based on a DNA Walker enables simultaneous and ultrasensitive detection of kanamycin and tobramycin
Gengchen Hu, Shizhao Liu, Yiming Zhang, Yao Jiang and Dongmei Xi
Chemical Engineering Journal, 2026, 535, 175576
DOI: 10.1016/j.cej.2026.175576

Triple signal amplification strategy for ultrasensitive in situ imaging of intracellular telomerase RNA
Juan Song, Shan Li, Jie Zhou, Qiao Yu, Xue-Jiao Yang, Hong-Yuan Chen and Jing-Juan Xu
Analytica Chimica Acta, 2023, 1256, 341145
DOI: 10.1016/j.aca.2023.341145

Sensitive Urine Immunoassay for Visualization of Lipoarabinomannan for Noninvasive Tuberculosis Diagnosis
Piaopiao Chen, Yanming Meng, Tangyuheng Liu, Wu Peng, Yue Gao, Yaqin He, Runlian Qu, Chunying Zhang, Walter Hu and Binwu Ying
ACS Nano, 2023, 17, 6998
DOI: 10.1021/acsnano.3c01374

Functional Nucleic Acids as Bacterial Biosensors: A Focus on Clostridioides difficile Infection
Kristie Chow and Yingfu Li
Analysis & Sensing, 2025, 5
DOI: 10.1002/anse.202400056

Discovery of a Dual‐Target DNAzyme for Clostridioides difficile and Listeria monocytogenes Diagnostics
Soyeon Lee, Dingran Chang, Jimmy Gu, Bruno J. Salena and Yingfu Li
ChemistryEurope, 2026, 4
DOI: 10.1002/ceur.202500352

Recent Advances in Nanozyme-Based Sensors for the Detection of Veterinary Drug Residues in Food
Hongyu Shen, Yi Fang, Xiuxiu Li, Dingyu Hu and Jinxin Cheng
Food Anal. Methods, 2025, 18, 2716
DOI: 10.1007/s12161-025-02895-8

Advances in colorimetric-photothermal dual-mode biosensors for food safety: Mechanism, applications and challenges
Suleiman Ibrahim Mohammad, Raed Obaid Saleh, Abdullah Ali Alzahrani, Asokan Vasudevan, A.K. Kareem, K.D.V. Prasad, Priyadharshini Bhupathi, Hafsan Hafsan, Fadhil Sead and Yasser Fakri Mustafa
Talanta, 2026, 298, 128838
DOI: 10.1016/j.talanta.2025.128838

Integrating DNA nanostructures with DNAzymes for biosensing, bioimaging and cancer therapy
Yifan Liu, Peng Zhu, Jin Huang, Hailun He, Changbei Ma and Kemin Wang
Coordination Chemistry Reviews, 2022, 468, 214651
DOI: 10.1016/j.ccr.2022.214651

The 10–23 DNAzyme in Biosensing and Diagnostics: Applications, Challenges, and Future Directions
Connor Nurmi, Jake Brill, Sanne Roumans, Amal Mathai, John D. Brennan and Yingfu Li
Angew Chem Int Ed, 2026
DOI: 10.1002/anie.7876181

Dual fluorescence output aptamer sensing of cortisol in Cushing syndrome samples assisted by tandem hybridization chain reaction
Xianghu Zeng, Ying Xiong, Li Yan, Pengjun Jiang, Xiaohui Lv, Jie Chen, Junlong Zhang and Piaopiao Chen
Sensors and Actuators B: Chemical, 2023, 384, 133673
DOI: 10.1016/j.snb.2023.133673

Enhanced Detection of Vibrio harveyi Using a Dual-Composite DNAzyme-Based Biosensor
Siying Li, Shuai Zhang, Weihong Jiang, Yuying Wang, Mingwang Liu, Mingsheng Lyu and Shujun Wang
Biosensors, 2024, 14, 548
DOI: 10.3390/bios14110548

Unnatural Amino Acid and Emerging Chemistry Approaches to Map RNA–Protein Interactions
Eryn Lundrigan, Parrish Evers, Elexa Scott and John Paul Pezacki
Angewandte Chemie, 2026, 138
DOI: 10.1002/ange.202520744

Detection of zearalenone by electrochemical aptasensor based on enzyme-assisted target recycling and DNAzyme release strategy
Jiating Wang, Yunzhe Zhang, Congyan Qi, Hui Xu, Xin Lu, Xiaoyan Ma and Wei Zhang
Talanta, 2025, 286, 127533
DOI: 10.1016/j.talanta.2025.127533

Fluorogenic Covalent Probes for RNA
Jinwoo Shin, Moon Jung Kim and Eric T. Kool
J. Am. Chem. Soc., 2025, 147, 44384
DOI: 10.1021/jacs.5c14938

Rational Design of Bio‐Inspired Peptide Electronic Materials toward Bionanotechnology: Strategies and Applications
Jingwen Zhao, Qingxi Liu, Xiaoyu Tong, Yuehui Wang, Kaiyong Cai and Wei Ji
Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202401466

A Versatile DNAzyme‐Amplified Protease‐Sensing Platform for Accurate Diagnosis of SARS‐CoV‐2 and Reliable Classification of Colorectal Cancer
Benrui Weng, Yifei Wang, Qingqing Zhang, Yuqian Jiang, Jinhua Shang, Xiaoqing Liu and Fuan Wang
Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202507241

Click DNA ligation with deoxyribozyme
Yangyang Chang, Yu Liang, Haodong Song, Qiang Zhang, Hong Yuan, Jiuxing Li, Zijie Zhang and Meng Liu
Nucleic Acids Research, 2025, 53
DOI: 10.1093/nar/gkaf991

A DNA Origami‐based Bactericide for Efficient Healing of Infected Wounds
Tiantian Wu, Hong Wang, Run Tian, Shuang Guo, Yuhui Liao, Jianbing Liu and Baoquan Ding
Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202311698

Expanding research and development of functional nucleic acids for agricultural applications
Yingfu Li
Advanced Agrochem, 2023, 2, 197
DOI: 10.1016/j.aac.2023.08.007

Optical biosensing with aptazyme driven DNA nanomachine utilizing CRISPR and CHA amplification for multiplex detection of pesticides and heavy metals
Sanwal Aslam, Jiahui Dai, Yunxian Lu, Fengxiang Ai, Zinian Cai, Rui Tan, Zhen Zhang and Hongjun Zhao
Microchemical Journal, 2025, 213, 113632
DOI: 10.1016/j.microc.2025.113632

The role of DNA-based biosensors in species identification for food authenticity assessment
Sara Barrias, Javier Ibáñez, José R. Fernandes and Paula Martins-Lopes
Trends in Food Science & Technology, 2024, 145, 104350
DOI: 10.1016/j.tifs.2024.104350

Nucleic Acid‐Based Molecular Machines for Biological Applications
Yirong Guo, Xiaolei Zuo and Fangfei Yin
Advanced NanoBiomed Research, 2025, 5
DOI: 10.1002/anbr.202400206

Recent Advances in Self-Assembled DNA Nanostructures for Bioimaging
Qi Yang, Xu Chang, Jung Yeon Lee, Tiffany R. Olivera, Minu Saji, Henry Wisniewski, Suchan Kim and Fei Zhang
ACS Appl. Bio Mater., 2022, 5, 4652
DOI: 10.1021/acsabm.2c00128

Signal-on fluorescent sensing strategy for Pb2+ detection based on 8–17 DNAzyme-mediated molecular beacon-type catalytic hairpin assembly circuit
Junyang Wang, Zheng Liu, Ying Li, Chuanyu Yang, Xinyue Ma, Hongxia Li and Chunyan Sun
Anal Bioanal Chem, 2022, 414, 6581
DOI: 10.1007/s00216-022-04218-w

Endogenous mRNA-Powered and Spatial Confinement-Derived DNA Nanomachines for Ultrarapid and Sensitive Imaging of Let-7a
Yinghui Feng, Shenghong Liu, Yao Yao, Miao Chen, Qi Liu and Xiaoqing Chen
Anal. Chem., 2024, 96, 564
DOI: 10.1021/acs.analchem.3c04837

Recent advance of RNA aptamers and DNAzymes for MicroRNA detection
Yeyu Wang, Qiqi Yang, Zhuangqiang Gao and Haifeng Dong
Biosensors and Bioelectronics, 2022, 212, 114423
DOI: 10.1016/j.bios.2022.114423

Recent Advancement in the development of hybridization chain reaction-based electrochemiluminescence biosensors
Ting Sun, Jia Du, Zhuo Li and Feng Zhao
International Journal of Electrochemical Science, 2022, 17, 220650
DOI: 10.20964/2022.06.35

Spatiotemporal dynamic and catalytically mediated reconfiguration of compartmentalized cyanuric acid/polyadenine DNA microdroplet condensates
Shijun Xu, Yu Ouyang, Yunlong Qin, Danlong Chen, Zhijuan Duan, Dongxing Song, Daniel Harries, Fan Xia, Itamar Willner and Fujian Huang
Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-58650-4

Fluorescent Determination of Calcium Ion by DNA Nanospheres Based Upon the EtNa DNAzyme
Fengyi Lin, Yuxin Cheng, Min Li, Jianfei Mao, Yunhua Liu, Cuisong Zhou, Jianyuan Dai, Yong Guo and Dan Xiao
Analytical Letters, 2024, 57, 2352
DOI: 10.1080/00032719.2023.2294135

Enzyme-free nucleic acid and luminescent material cascade amplifications enable urinary dual miRNAs assay for non-invasive bladder cancer diagnosis
Li Yan, Yunjin Bai, Juan Zhou, Yaqin He, Congcong Shen, Jin Huang and Piaopiao Chen
Sensors and Actuators B: Chemical, 2023, 396, 134627
DOI: 10.1016/j.snb.2023.134627

A DNA Origami‐based Bactericide for Efficient Healing of Infected Wounds
Tiantian Wu, Hong Wang, Run Tian, Shuang Guo, Yuhui Liao, Jianbing Liu and Baoquan Ding
Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202311698

Advancements and Prospects in DNA-Based Bioanalytical Technology for Environmental Toxicant Detection
Siqian Liu, Benfeng Xu, Chongyang Li, Yanlin Ren, Hao Gan, Shi Kuang, Chunyang Lei and Zhou Nie
JACS Au, 2025, 5, 2443
DOI: 10.1021/jacsau.5c00398

Engineering Acidic Deoxyribozyme with Strongly Cooperative H+ Binding for Subcellular Imaging
Pan Jia, Qihan Meng, Qiang Zhang, Rui Zhang, Zijie Zhang, Jiuxing Li, Xin Wang, Yanbiao Liu, Yangyang Chang and Meng Liu
Anal. Chem., 2025, 97, 9378
DOI: 10.1021/acs.analchem.5c00535

DNA-based enzymatic systems and their applications
Yunfei Jiao, Yingxu Shang, Na Li and Baoquan Ding
iScience, 2022, 25, 104018
DOI: 10.1016/j.isci.2022.104018

Visualized lateral flow assay for logic determination of co-existing viral RNA fragments
Juanjuan Song, Chuhao Zhang, Siting Fu and Xiaowen Xu
Biosensors and Bioelectronics, 2024, 261, 116519
DOI: 10.1016/j.bios.2024.116519

Bi2WO6-based photoelectrochemical biosensor with DNAzyme-assisted amplification strategy for Pb2+ analysis
Mengjie Li, Yuanbo Ding, Guohao Shen, Jiayue Jiang and Wei Liu
Microchemical Journal, 2025, 218, 115393
DOI: 10.1016/j.microc.2025.115393

Development of electrochemical biosensor utilizing Fe3O4@Au and DNAzyme-mediated polymerase strand displacement amplification for the detection of nickel ions
Siying Wu, Huaying A, Fuping Li, Yanli Zhang, Xue Men, Hongbin Wang, Wenrong Yang and Pengfei Pang
Microchemical Journal, 2026, 221, 116843
DOI: 10.1016/j.microc.2026.116843

A persistent luminescent nanobeacon for practical detection of lead ions via avoiding background interference
Qi Luo, Lingfeng Qin, Peng Zhang, Bo Feng, Xiaosheng Ye, Taiping Qing and Zhihe Qing
Analytica Chimica Acta, 2022, 1198, 339555
DOI: 10.1016/j.aca.2022.339555

Highly Sensitive and Selective Detection of Uranyl Ions Based on a Tb3+-Functionalized MOF via Competitive Host–Guest Coordination
Jian Xie, Jinpeng Liang, Ji Lei, Yiheng Xiao, Feng Luo and Baowei Hu
Inorg. Chem., 2025, 64, 3616
DOI: 10.1021/acs.inorgchem.4c05586

Framework Nucleic Acid‐Mediated DNAzyme Chaperoning for Sensitive Trace Metal Ion Mapping on Live Neuronal Cell Membranes
Tianqi Xu, Fan Li, Yichao Jin, Feng Jia, Yu Wang, Tao Lv, Yueyue Zhang, Min Li, Chunhai Fan, Mingqiang Li, Xiaohua Zhang, Shaopeng Wang and Xiaolei Zuo
Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202506640

An intramolecular DNAzyme-based amplification for miRNA analysis with improving reaction kinetics and high sensitivity
Ting Huang, Guixun Chen, Birong Liu, Zizhong Yang, Yuanwei Huang, Baoping Xie, Min-Min Li, Jin-Xiang Chen, Jun Chen and Zong Dai
Talanta, 2022, 239, 123137
DOI: 10.1016/j.talanta.2021.123137

PRESENCE OF LEGIONELLA PNEUMOPHILA IN TAP WATER AND ITS IMPORTANCE FOR PUBLIC HEALTH
Ömer Çakmak, Tuba Aldemir, Erdi Ergene, Ulaş Acaröz, Damla Arslan-acaroz and Nuri Taş
Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni, 2024, 15, 64
DOI: 10.38137/vftd.1432171

In situ microRNA-triggered self-assembled nano-lanterns with confinement effect for imaging-guided dual-enhanced gene therapy
Xianlan Wu, Hanqing Xu, Xiaoqi Tang, Jiangbo Liu, Qingxiang Yang, Qian Liu, Ping Huang, Shuang Zhao, Ming Chen and Kai Chang
Chemical Engineering Journal, 2025, 519, 165386
DOI: 10.1016/j.cej.2025.165386

DNAzyme-Based Microscale Thermophoresis Sensor
Hao Yu and Qiang Zhao
Anal. Chem., 2023, 95, 2152
DOI: 10.1021/acs.analchem.2c04643

Aptamer and DNAzyme Based Colorimetric Biosensors for Pathogen Detection
Rudi Liu, Jiuxing Li, Bruno J. Salena and Yingfu Li
Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202418725

A DNA Aptamer for Theophylline with Ultrahigh Selectivity Reminiscent of the Classic RNA Aptamer
Po-Jung Jimmy Huang and Juewen Liu
ACS Chem. Biol., 2022, 17, 2121
DOI: 10.1021/acschembio.2c00179

The Biomedical Applications of Biomolecule Integrated Biosensors for Cell Monitoring
Kyeongseok Song, Soon-Jin Hwang, Yangwon Jeon and Youngdae Yoon
IJMS, 2024, 25, 6336
DOI: 10.3390/ijms25126336

Spherical DNA Nanomotors Enable Ultrasensitive Detection of Active Enzymes in Extracellular Vesicles for Cancer Diagnosis
Jinqi Deng, Shuai Zhao, Kai Xie, Chao Liu, Chuangui Sheng, Junhong Li, Bo Dai, Shuo Wan, Lele Li and Jiashu Sun
Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202417165

Single Multifunctional Nanocabinets‐Based Target‐Activated Feedback for Simultaneously Precise Monitoring and Therapy
Binxiao Li, Yanwei Lu, Xuedong Huang, Yujun Ning, Qian Shi, Jianwei Liu and Baohong Liu
Small, 2024, 20
DOI: 10.1002/smll.202305777

Ultrasensitive electrochemiluminescence biosensors based on programmable aptazyme-induced hybridization chain reaction for detecting adenosine triphosphate and quinine
Yongmei Liu, Huifang Bian, Yang Wu, Yongde Yin, Jiangmin Wu, Zhengdong Peng and Jie Du
Sensors and Actuators B: Chemical, 2022, 369, 132266
DOI: 10.1016/j.snb.2022.132266

Carbon Dots in Bioimaging, Biosensing and Therapeutics: A Comprehensive Review
Boyang Wang, Huijuan Cai, Geoffrey I. N. Waterhouse, Xiaoli Qu, Bai Yang and Siyu Lu
Small Science, 2022, 2
DOI: 10.1002/smsc.202200012

Enzyme-Triggered DNA Sensor Technology for Spatially-Controlled, Cell-Selective Molecular Imaging
Mengyuan Li and Lele Li
Acc. Chem. Res., 2023, 56, 1482
DOI: 10.1021/acs.accounts.3c00085

Ratiometric Detection of Zn2+ Using DNAzyme-Based Bioluminescence Resonance Energy Transfer Sensors
Yuting Wu, Whitney Lewis, Jing Luen Wai, Mengyi Xiong, Jiao Zheng, Zhenglin Yang, Chloe Gordon, Ying Lu, Siu Yee New, Xiao-Bing Zhang and Yi Lu
Chemistry, 2023, 5, 1745
DOI: 10.3390/chemistry5030119

Signal Amplification by the trans-Cleavage Activity of CRISPR-Cas Systems: Kinetics and Performance
Wei Feng, Hongquan Zhang and X. Chris Le
Anal. Chem., 2023, 95, 206
DOI: 10.1021/acs.analchem.2c04555

Site‐Specific Recognition of Inosine‐Modified RNA by Deoxyribozyme with Distant Cleavage Site
Shusen Xiao, Yangyang Chang, Pan Jia, Xiaoqian Li, Xia Li, Xiaozheng Li, Hong Yuan, Jiuxing Li, Zijie Zhang and Meng Liu
Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202513587

Recent Advance in Electrochemical Chiral Recognition Based on Biomaterials (2019–2024)
Shan Qiu, Guo-Ying Chen, Yi-Dan Qin, Ting-Ting Li and Feng-Qing Yang
Molecules, 2025, 30, 3386
DOI: 10.3390/molecules30163386

A Combined Aptamer Pulldown‐DNAzyme Cleavage Assay for Intact Methicillin Resistant Staphylococcus aureus Cells
Monsur Ali, Abigail F. Almeida, Dawn White, Alfredo Capretta and John D. Brennan
Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202509598

An RNA‐Cleaving DNAzyme That Requires an Organic Solvent to Function
Tianjun Chang, Guangping Li, Dingran Chang, Ryan Amini, Xiaoni Zhu, Tongqian Zhao, Jimmy Gu, Zhongping Li and Yingfu Li
Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202310941

A self-feedback dual-walker nanosystem for sensitive miRNA detection and intracellular imaging
Jiabin Yang and Min Wang
Analytica Chimica Acta, 2026, 1386, 345042
DOI: 10.1016/j.aca.2025.345042

Recent advances in protein biomarkers based enzymatic biosensors for non-communicable diseases
Amandeep Kaur, Rishika Rohilla, Shilpa Rana, Sonia Rani and Nirmal Prabhakar
TrAC Trends in Analytical Chemistry, 2024, 174, 117683
DOI: 10.1016/j.trac.2024.117683

Multi-Cantilevered Tetrahedral DNA Spider (TDSpider): An Efficient Molecular Machine for Biometrics and Disease Diagnosis
Ziyan Li, Jing Zhou, Xiaobo Xie, Rui Liu, Jianyu Hu and Yi Lv
Anal. Chem., 2025, 97, 18553
DOI: 10.1021/acs.analchem.5c02472

Non‐Derailed DNA Harvester for Persistently Harvesting Information on Malignant Degree of Tumor Cells via High‐Confidence Quantification of Biomarkers
Wenhao Pan, Chang Xue, Qian Gao, Mengxue Luo, Dongyu Li, Linhuan Chen, Shidan Zhu, Zhifa Shen and Zai‐Sheng Wu
Adv Funct Materials, 2026
DOI: 10.1002/adfm.202527744

A Rapid Sputum‐based Lateral Flow Assay for Airway Eosinophilia using an RNA‐cleaving DNAzyme Selected for Eosinophil Peroxidase
M. Monsur Ali, Manali Mukherjee, Katherine Radford, Zil Patel, Alfredo Capretta, Parameswaran Nair and John D. Brennan
Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202307451

Potential adoption of electrochemical biosensors for cancer DNA biomarker detection in liquid biopsies: A systematic review
Anouk Peymen, Thijs Van der Snickt, Alejandro Valverde, Scott Ailliet, Karen Zwaenepoel, Pieter Mestdagh and Karolien De Wael
Talanta, 2026, 304, 129488
DOI: 10.1016/j.talanta.2026.129488

Homogeneous Dual Fluorescence Count of CD4 in Clinical HIV-Positive Samples via Parallel Catalytic Hairpin Assembly and Multiple Recognitions
Xiaoqi Ou, Zhengli Wan, Ying Xiong, Ke Huang, Zeliang Wei, Zulimire Nuermaimaiti, Yanting Chen, Duerdanna Yiliya, Hongyin Lin, Zhenjie Dai, Yi Li and Piaopiao Chen
ACS Appl. Mater. Interfaces, 2023, 15, 38285
DOI: 10.1021/acsami.3c06742

Potential application of aptamers combined with DNA nanoflowers in neurodegenerative diseases
Zhongci Hang, Liping Zhou, Xiaochun Bian, Guotao Liu, Fenghe Cui, Hongwu Du and Yongqiang Wen
Ageing Research Reviews, 2024, 100, 102444
DOI: 10.1016/j.arr.2024.102444

Endogenous HClO-Gated Cascade MicroRNA Imaging for Precise Diagnosis of Atherosclerosis In Vivo
Moxuan Ji, Jiantong Dong, Zhuo Ye, Jingjing Kang, Guimei Han, Xiaoqin Hong, Yongchun Wei, Xin Chen, Wei Sun and Dingbin Liu
J. Am. Chem. Soc., 2025, 147, 7113
DOI: 10.1021/jacs.5c00031

Advances in DNAzyme Selection, Molecular Engineering and Biomedical Applications
Li Yan, Jingjing Tian, Hongyu Yang, Shuai Liu, Zaihui Du, Chen Li and Hongtao Tian
IJMS, 2026, 27, 1833
DOI: 10.3390/ijms27041833

Therapeutic DNAzymes: From Structure Design to Clinical Applications
Jiaqi Yan, Meixin Ran, Xian Shen and Hongbo Zhang
Advanced Materials, 2023, 35
DOI: 10.1002/adma.202300374

DNA Conformation-Regulated Hemin Switch for Lab-on-Chip Chemiluminescent Detection of an Antibody Secreted from Hybridoma Cells
Hang Ao, Wencheng Xiao, Wenrui Hu, Jie Wu and Huangxian Ju
Anal. Chem., 2024, 96, 18502
DOI: 10.1021/acs.analchem.4c04122

The nucleic acid reactions on the nanomaterials surface for biomedicine
Zhenrui Xue, Lu Wang, Shengnan Pan, Jie Yan, Minli You and Chunyan Yao
J Nanobiotechnol, 2025, 23
DOI: 10.1186/s12951-025-03374-2

DNA-Driven Dynamic Assembly/Disassembly of Inorganic Nanocrystals for Biomedical Imaging
Shengfei Yang, Yuqi Wang, Qiyue Wang, Fangyuan Li and Daishun Ling
Chemical & Biomedical Imaging, 2023, 1, 340
DOI: 10.1021/cbmi.3c00028

A Membrane-Confined Signal Amplification Strategy for Sensitive Monitoring of Extracellular Enzymatic Activity Upon Drug Stimulus
Yiyi Zhang, Deyu Yi, Meichan Su, Zhengping Li and Mengyuan Li
Anal. Chem., 2024, 96, 13191
DOI: 10.1021/acs.analchem.4c02120

A sequentially activatable DNAzyme nanosystem for augmented tumor gene silencing and radiosensitization
Han Wu, Xianzhou Cai, Hao Jiang, Qin Fan, Jifeng Li, Wenjun Zhu, Longyu Zhao, Yingjie Ren, Ziliang Dong and Lianhui Wang
Chemical Engineering Journal, 2026, 532, 174188
DOI: 10.1016/j.cej.2026.174188

Early growth response-1: Key mediators of cell death and novel targets for cardiovascular disease therapy
Yixin Xie, Yongnan Li, Jianshu Chen, Hong Ding and Xiaowei Zhang
Front. Cardiovasc. Med., 2023, 10
DOI: 10.3389/fcvm.2023.1162662

Sensitive detection of FPG based on 8-oxoG modified chimeric peptide-DNA enzyme for oxidative damage evaluation
Tian Wang, Yuan Liu, Bin Liu, Xinrong Yan, Dehui Qiu, Shijiong Wei, Desheng Chen, Dechen Jiang, Jun Zhou, Huangxian Ju and Xiaobo Zhang
Talanta, 2025, 283, 127118
DOI: 10.1016/j.talanta.2024.127118

Recent Advances in DNA Nanotechnology for Plasmonic Biosensor Construction
Jeong Ah Park, Chaima Amri, Yein Kwon, Jin-Ho Lee and Taek Lee
Biosensors, 2022, 12, 418
DOI: 10.3390/bios12060418

Dual-functional DNAzyme powered CRISPR-Cas12a sensor for ultrasensitive and high-throughput detection of Pb2+ in freshwater
Junlin Wen, Hongjie Deng, Daigui He and Yong Yuan
Science of The Total Environment, 2024, 911, 168708
DOI: 10.1016/j.scitotenv.2023.168708

A Non‐G‐Quadruplex Hemin Aptamer Forms a Better Peroxidase Mimicking DNAzyme
Claudia Rodríguez‐Almazán, Yunus A. Kaiyum, Philip E. Johnson and Juewen Liu
ChemBioChem, 2025, 26
DOI: 10.1002/cbic.202500486

Upconversion Luminescence‐Boosted Escape of DNAzyme from Endosomes for Enhanced Gene‐Silencing Efficacy
Yaoxuan Chen, Rupeng Zhao, Lele Li and Yuliang Zhao
Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202206485

Growth Control of Metal–Organic Framework Films on Marine Biological Carbon and Their Potential-Dependent Dopamine Sensing
Xinyi Ke, Zhe Zhao, Jiayuan Huang, Chang Liu, Gaoshan Huang, Ji Tan, Hongqin Zhu, Zhijia Xiao, Xuanyong Liu, Yongfeng Mei and Junhao Chu
ACS Appl. Mater. Interfaces, 2023, 15, 12005
DOI: 10.1021/acsami.2c20517

Constructing DNAzyme-driven three-dimensional DNA nanomachine-mediated paper-based photoelectrochemical device for ultrasensitive detection of miR-486-5p
Yuanyuan Chen, Jiaxin Liang, Xiaoran Tan, Li Shan, Lina Zhang, Li Li, Shenguang Ge, Kang Cui and Jinghua Yu
Biosensors and Bioelectronics, 2023, 241, 115671
DOI: 10.1016/j.bios.2023.115671

Functional nucleic acid-based biosensing for m6A-modifying enzyme activity monitoring
Zhiyan Chen, Xiyue Zhang, Ping Huang and Minghua Ge
TrAC Trends in Analytical Chemistry, 2026, 194, 118485
DOI: 10.1016/j.trac.2025.118485

Construction of molecular logic gates using heavy metal ions as inputs based on catalytic hairpin assembly and CRISPR-Cas12a
Jiafeng Pan, Fang Deng, Zhi Liu, Lingwen Zeng and Junhua Chen
Talanta, 2023, 255, 124210
DOI: 10.1016/j.talanta.2022.124210

Overcoming Major Barriers to Developing Successful Sensors for Practical Applications Using Functional Nucleic Acids
JingJing Zhang, Tian Lan and Yi Lu
Annual Rev. Anal. Chem., 2022, 15, 151
DOI: 10.1146/annurev-anchem-061020-104216

Nucleic Acid Drugs in Radiotherapy
Yuying Yang, Cai Yang, Kai Deng, Yating Xiao, Xiangsheng Liu and Zhen Du
ChemBioChem, 2025, 26
DOI: 10.1002/cbic.202400854

Programmable Split DNAzyme Modulators via Allosteric Cooperative Activation for mRNA Electrochemiluminescence Biosensing
Liu-Qing Tan, Wei-Jia Zeng, Qiao-Lin Chen, Xiu-Li Tao, Ruo Yuan, Yan-Mei Lei and Ying Zhuo
Anal. Chem., 2025, 97, 5789
DOI: 10.1021/acs.analchem.4c07071

A localized DNA finite-state machine with temporal resolution
Lan Liu, Fan Hong, Hao Liu, Xu Zhou, Shuoxing Jiang, Petr Šulc, Jian-Hui Jiang and Hao Yan
Sci. Adv., 2022, 8
DOI: 10.1126/sciadv.abm9530

Ratiometric G-quadruplex/hemin DNAzymes with low-dosage associative substrates
Rong Lai, Xingli Zeng, Qiuda Xu, Ying Xu, Xueni Li, Yulu Ru, Yilin Wang, Dandan Wang, Xiaoshun Zhou and Yong Shao
Analytica Chimica Acta, 2024, 1295, 342320
DOI: 10.1016/j.aca.2024.342320

Parallel Detection of Mixed Pesticides Based on Dual Quantum Dot/Porous Silicon Optical Biosensors
Jianghong Cao, Zhenhong Jia, Haitao Yue, Jie Yang, Jiajia Wang, Xiaoyi Lv and Xiaohui Huang
IEEE Sensors J., 2024, 24, 38596
DOI: 10.1109/JSEN.2024.3469251

Construction of a hierarchical DNA circuit for single-molecule profiling of locus-specific N6-methyladenosine-MALAT1 in clinical tissues
Qian Liu, Bao-mei Zhou, Li-juan Wang and Chun-yang Zhang
Biosensors and Bioelectronics, 2025, 274, 117198
DOI: 10.1016/j.bios.2025.117198

Recent Advances on DNAzyme‐Based Sensing
Zhimei Huang, Xiangnan Wang, Zhenkun Wu and Jian‐Hui Jiang
Chemistry — An Asian Journal, 2022, 17
DOI: 10.1002/asia.202101414

Structure-controllable Ag aerogel optimized SERS-digital microfluidic platform for ultrasensitive and high-throughput detection of harmful substances
Zihan Wang, Wei Liu, Jie Wang, LongJin Huang, Sheng Cui and Xuan He
Sensors and Actuators B: Chemical, 2024, 401, 134934
DOI: 10.1016/j.snb.2023.134934

Spherical DNA Nanomotors Enable Ultrasensitive Detection of Active Enzymes in Extracellular Vesicles for Cancer Diagnosis
Jinqi Deng, Shuai Zhao, Kai Xie, Chao Liu, Chuangui Sheng, Junhong Li, Bo Dai, Shuo Wan, Lele Li and Jiashu Sun
Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202417165

Nucleic Acid Enzyme‐Activated CRISPR‐Cas12a With Circular CRISPR RNA for Biosensing
Yunping Wu, Dingran Chang, Yangyang Chang, Qiang Zhang, Yi Liu, John D. Brennan, Yingfu Li and Meng Liu
Small, 2023, 19
DOI: 10.1002/smll.202303007

Bioreceptors as the key components for electrochemical biosensing in medicine
Xueqi Wang, Jianhua Zhou and Han Wang
Cell Reports Physical Science, 2024, 5, 101801
DOI: 10.1016/j.xcrp.2024.101801

DNAzyme-based biosensing for food safety
Xiangyi Liu , Han Wu , Dong Wang , Longgang Ma , Xujun Chen , Marina A Nikitina, Irina Chernukha and Xinqing Xiao
Food Quality and Safety, 2025, 9
DOI: 10.1093/fqsafe/fyaf028

Triplet Excimer Formation in a DNA Duplex with Silver Ion-Mediated Base Pairs
Lara Martínez-Fernández, Forrest R. Kohl, Yuyuan Zhang, Supriya Ghosh, Andrew J. Saks and Bern Kohler
J. Am. Chem. Soc., 2024, 146, 1914
DOI: 10.1021/jacs.3c08793

A DNAzyme‐Based Nanohybrid for Ultrasound and Enzyme Dual‐Controlled mRNA Regulation and Combined Tumor Treatment
Hanji Huang, Yaoxuan Chen, Lele Li and Li Zheng
Advanced Materials, 2024, 36
DOI: 10.1002/adma.202409035

An Electrochemical Aptasensor with Enhanced Electrocatalytic Signal by Electrode Modification Material for Aflatoxin B1 Detection-Based Bipedal DNAzyme Cleavage Effect
Xiaodong Lu, Xinyi Liu, Qiaodie Wang, Xiaoze Dong, Mingwei Qin, Gengli Huang, Xiang Han, Yiyao Wu and Zhouping Wang
Anal. Chem., 2025, 97, 26793
DOI: 10.1021/acs.analchem.5c05580

Synergistic Effects of Hydrophobicity and Negative Charge on the Nanopore Surface for the Dual-Amplified Iontronic Detection of MicroRNA
Jiangxue Dong, Jingjing Wang, Yufan Zhang, Tianyi Lu, Yajie Fan, Yanlei Li, Hongyuan Yan, Shigang Shen, Qun Ma, Zhongfeng Gao, Qin Wei and Fan Xia
ACS Sens., 2025, 10, 5217
DOI: 10.1021/acssensors.5c01391

Hafnium metal-organic frameworks coupling with DNAzyme-driven bipedal DNA walkers as dual-mode aptasensing platform for sensitive detection of ochratoxin A
Zhuangzhuang Ru, Jingui Chen, Luyang Lv, Ning Gao, Xiang Ren, Yu Du, Lei Yang and Qin Wei
Chemical Engineering Journal, 2025, 519, 165379
DOI: 10.1016/j.cej.2025.165379

Dual-palindrome chained assembly regulates the formation of palindromic DNAzyme wire transducers empowering sensitized and one-step copper ion- dependent assay
Xinlei Zhang, Jianguo Xu, Yubo Peng, Changyang Ma, Xinxin Wang, Huijie Shang, Li Yao and Wei Chen
Sensors and Actuators B: Chemical, 2022, 370, 132471
DOI: 10.1016/j.snb.2022.132471

High affinity and selective DNA aptamers for the detection of tobramycin in eye drops
Xiaohan Zhang, Emily Hoi Pui Chao, Qiushi Liu, Xinyuan Mu, Boya Zhao, Ka-Ying Wong, Philip E. Johnson and Juewen Liu
Biosensors and Bioelectronics, 2026, 303, 118569
DOI: 10.1016/j.bios.2026.118569

Subcellular Compartment‐Specific Amplified Imaging of Metal Ions via Ribosomal RNA‐Regulated DNAzyme Sensors
Deyu Yi, Lele Li and Mengyuan Li
Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202412387

DNAzyme-Based Lithium-Selective Imaging Reveals Higher Lithium Accumulation in Bipolar Disorder Patient-Derived Neurons
Claire E. McGhee, Zhenglin Yang, Weijie Guo, Yuting Wu, Mingkuan Lyu, Cynthia J. DeLong, Shanni Hong, Yuan Ma, Melvin G. McInnis, K. Sue O’Shea and Yi Lu
ACS Cent. Sci., 2021, 7, 1809
DOI: 10.1021/acscentsci.1c00843

A magnetically assisted aptamer-DNAzyme sensing platform coupled with advanced multivariate calibration for highly sensitive detection of aflatoxin B1
Sha Chen, ZiXin Shen, Jie Peng, Ying Tang, Yao Chen and DeHuan Yang
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2026, 349, 127254
DOI: 10.1016/j.saa.2025.127254

Neuroblastoma‐Targeting π‐Conjugated COP Nanostructure with Multiple Enzyme‐Mimetic Actions for Sonochemodynamic Immunotherapies
Qian Li, Tian Tian, Wei Geng, Xiaotong Huang, Xiaohui Xu, Mohsen Adeli, Xiaolin Wang, Liang Cheng, Tian Ma, Hong Luo, Lang Ma and Chong Cheng
Advanced Materials, 2025, 37
DOI: 10.1002/adma.202503261

Enhancing Selectivity in Affinity Biosensors through Biorecognition-Driven Suppression of Nonspecific Binding
Yang Zhang, Feng Hu, Ruiyun Zhou, Tianxi Yang, Pengcheng Cai, Pierre Picchetti, Xiaowei Huang, Zhihua Li, Xiaodong Zhai, Roujia Zhang, Junjun Zhang, Jiyong Shi, Zhiming Guo, Shipeng Gao and Xiaobo Zou
ACS Sens., 2026, 11, 853
DOI: 10.1021/acssensors.5c03955

A turn-on fluorescence strategy for hypochlorous acid detection based on DNAzyme-assisted cyclic signal amplification
Jiaqi Xu, Xi Zhou, Hailun He, Shanni Li and Changbei Ma
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2023, 303, 123243
DOI: 10.1016/j.saa.2023.123243

Simultaneous Imaging of Cu+ and Cu2+ in Neural Cells Using DNAzyme Probes Reveals Mechanistic Link Between Copper Redox Imbalance and Amyloid Pathology
Xiangli Shao, Zhenglin Yang, Zhihao Xu, Weijie Guo, Whitney Lewis, Boyi Gan and Yi Lu
Angewandte Chemie, 2026, 138
DOI: 10.1002/ange.202524237

Research progress in the detection of common foodborne hazardous substances based on functional nucleic acids biosensors
Zijie Chen, Zhen Liu, Jingjing Liu and Xilin Xiao
Biotech & Bioengineering, 2023, 120, 3501
DOI: 10.1002/bit.28555

Chemical Engineering of DNAzyme for Effective Biosensing and Gene Therapy
Rong Wang, Zhimei Huang, Zhenkun Wu, Xin Li and Jian‐Hui Jiang
Small Methods, 2025, 9
DOI: 10.1002/smtd.202401514

Functional nucleic acid-based biosensors for virus detection
Zijie Zhang, Bal Ram Adhikari, Payel Sen, Leyla Soleymani and Yingfu Li
Advanced Agrochem, 2023, 2, 246
DOI: 10.1016/j.aac.2023.07.006

A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells
Mengru Lin, Jiale Sun, Yuqing Mao, Yuhao Tang, Fuan Wang, Zhihong Liu and Jing Wang
Advanced Science, 2026, 13
DOI: 10.1002/advs.202517895

An Enzymatically Gated Catalytic Hairpin Assembly Delivered by Lipid Nanoparticles for the Tumor‐Specific Activation of Signal Amplification in miRNA Imaging
Qing Liu, Yuanyu Huang, Zhengping Li, Lele Li, Yuliang Zhao and Mengyuan Li
Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202214230

Integrating Fluorogenic DNAzymes with Photonic Crystals for Bacterial Detection on a Microfluidic Biochip
Rui Zhang, Chen An, Jiuxing Li, Xiaozheng Li, Qiang Zhang, Qing’an Li, Shen Li, Bo Wang, Xiaoqian Li, Yangyang Chang, Zijie Zhang and Meng Liu
Anal. Chem., 2025, 97, 16950
DOI: 10.1021/acs.analchem.5c02447

Topology-Informed Design of Circularly Locked DNAzymes Enables Orthogonally Controlled Gene Regulation
Fangzhi Yu, Siqi Zhang, Huanyu Tao, Haozhe Jin, Yuliang Zhao, Sheng-You Huang and Lele Li
J. Am. Chem. Soc., 2026, 148, 3365
DOI: 10.1021/jacs.5c18154

Integration of Isothermal Enzyme‐Free Nucleic Acid Circuits for High‐Performance Biosensing Applications
Siyuan Wang, Jinhua Shang, Bingyue Zhao, Huimin Wang, Changying Yang, Xiaoqing Liu and Fuan Wang
ChemPlusChem, 2023, 88
DOI: 10.1002/cplu.202300432

Exploring Site-Specific N6-Methyladenosine Modifications as New Cancer Biomarkers via SERS-Based Single-Cell Assay and Histopathological Imaging
Sijia Sun, Dan Xie, Wenyan Guan, Qi Li, Jian He, Ying Li, Jingran Chen, Song Gao and Zhen Liu
Anal. Chem., 2025, 97, 16822
DOI: 10.1021/acs.analchem.5c01864

Multidomain Molecular Sensor Devices, Systems, and Algorithms for Improved Physiological Monitoring
Lianna D. Soriano, Shao-Xiang Go, Lunna Li, Natasa Bajalovic and Desmond K. Loke
Micromachines, 2025, 16, 900
DOI: 10.3390/mi16080900

Stimuli‐Responsive DNA Circuits for High‐Performance Bioimaging Application
Qiong Wu, Mengqing Xu, Jinhua Shang, Shizhen He, Xiaoqing Liu and Fuan Wang
Advanced Sensor Research, 2023, 2
DOI: 10.1002/adsr.202200102

Investigating on sensing mechanism of MoS2-FET biosensors in response to proteins
Ziheng Ji, Junqing Wei, Fengting Luo, Zihao Liu, Haotian Lu, Ruibing Chen, Yong Wang and Guoxuan Qin
Nanotechnology, 2023, 34, 435503
DOI: 10.1088/1361-6528/aceb6a

Functional Nucleic Acid Enzymes: Nucleic Acid-Based Catalytic Factories
Min Yang, Yushi Xie, Longjiao Zhu, Xiangyang Li and Wentao Xu
ACS Catal., 2024, 14, 16392
DOI: 10.1021/acscatal.4c02670

DNA Nanotechnology Targeting Mitochondria: From Subcellular Molecular Imaging to Tailor‐Made Therapeutics
Fangzhi Yu, Xiangfei Li, Chuangui Sheng and Lele Li
Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202409351

Spatial Confinement of a Dual Activatable DNAzyme Sensor in the Cavity of a DNA Nanocage for Logic‐Gated Molecular Imaging
Tingting Tu, Shuangyan Huan, Xueyan Feng, Guoliang Ke, Lele Li and Xiao‐Bing Zhang
Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202424684

Ultrasensitive detection of lead ion in tea samples using a versatile and robust multi-DNAzyme DNA machine mediated CRISPR/Cas12a signal amplification system
Yubo Peng, Jianguo Xu, Baoqiang Chen, Dexin Zeng, Xiaofeng Yu and Wei Chen
Food Chemistry, 2026, 499, 147352
DOI: 10.1016/j.foodchem.2025.147352

A Microcavity Chemiluminescent Immunoimaging Protocol for Fast in Situ Detection of Antibody Secreted from Single Hybridoma Cells
Hang Ao, Wencheng Xiao, Weiwei Chen, Wenrui Hu, Jie Wu and Huangxian Ju
Small Methods, 2026, 10
DOI: 10.1002/smtd.202500656

DNA integrated nanostructures for optical-based detection of foodborne contaminants
Mehdi Dadmehr, Elnaz Ahmadi Sangachin, Fatima Bazzi, Jiuxing Li and Morteza Hosseini
TrAC Trends in Analytical Chemistry, 2024, 178, 117836
DOI: 10.1016/j.trac.2024.117836

Tumor microenvironment-responsive dynamic self-assembly of DNAzyme nanowires for high-contrast imaging of multiple messenger RNAs and chemotherapy
Huimin Yuan, Hai-juan Li, Li-juan Wang and Chun-yang Zhang
Biosensors and Bioelectronics, 2025, 287, 117728
DOI: 10.1016/j.bios.2025.117728

MicroRNA‐Triggered Programmable DNA‐Encoded Pre‐PROTACs for Cell‐Selective and Controlled Protein Degradation
Jiayin Zhan, Xiang Li, Zhe Feng, Zheng Liu, Zhiyuan Feng, Jun‐Jie Zhu and Jingjing Zhang
Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202415323

A Combined Aptamer Pulldown‐DNAzyme Cleavage Assay for Intact Methicillin Resistant Staphylococcus aureus Cells
Monsur Ali, Abigail F. Almeida, Dawn White, Alfredo Capretta and John D. Brennan
Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202509598

Cell-Membrane-Anchored Synthetic Dynamic DNA Circuits for Signaling Transient Cell Migration
Nina Lin, Yu Ouyang, Yunlong Qin, Songqin Liu, Itamar Willner, Yuanjian Zhang and Zhixin Zhou
J. Am. Chem. Soc., 2025, 147, 34292
DOI: 10.1021/jacs.5c03070

Target-initiated autocatalytic and concatenated DNAzyme/CHA amplification cascades for highly sensitive fluorescent detection of TET1 dioxygenase
Daxiu Li, Jie Xiang, Yanni Wang, Yun Xiang and Ruo Yuan
Talanta, 2025, 293, 128114
DOI: 10.1016/j.talanta.2025.128114

In‐vitro Clinical Diagnostics using RNA‐Cleaving DNAzymes
Monsur Ali, Parameswaran Nair, Alfredo Capretta and John D. Brennan
ChemBioChem, 2024, 25
DOI: 10.1002/cbic.202400085

Overview on the Design of Magnetically Assisted Electrochemical Biosensors
Yong Chang, Yanyan Wang, Jingyi Zhang, Yuejiao Xing, Gang Li, Dehua Deng and Lin Liu
Biosensors, 2022, 12, 954
DOI: 10.3390/bios12110954

Cascade-amplification-based electrochemical detection of Akashiwo sanguinea at pre-outbreak stage
Changrui Ye, Hongjie Liu, Shaopeng Wang, Man Zhang, Chaoxin Zhang, Fulin Yang, Fang Shen and Liwei Wang
Talanta, 2025, 287, 127671
DOI: 10.1016/j.talanta.2025.127671

Discovery and translation of functional nucleic acids for clinically diagnosing infectious diseases: Opportunities and challenges
Jiuxing Li, Zijie Zhang, Rudi Liu, Ryan Amini, Bruno J. Salena and Yingfu Li
TrAC Trends in Analytical Chemistry, 2023, 158, 116886
DOI: 10.1016/j.trac.2022.116886

Programming an antibody-peptide sandwich procedure for selectivity and ultrasensitive detection of fibrin using double-stranded DNA (dsDNA) hemp string probe
Jinrong Zhang, Yuanfu Zhang, Yawei Chen, Xue Zhao, Youzhen Hao, Qing Wang Xue and Shuhao Wang
Sensors and Actuators B: Chemical, 2023, 379, 133296
DOI: 10.1016/j.snb.2023.133296

Designing Nuclease‐Resistant Enzyme‐Mimicking Assemblies of Oligonucleotides Through Supramolecular Conjugation with Platinum(II) Complexes
Alisha Kamra, Rohit Kapila, Abhay Srivastava, Bhaskar Sen and Subinoy Rana
Angewandte Chemie, 2026, 138
DOI: 10.1002/ange.202522266

Updates on niosomes in interfering nucleic acid delivery for cancer treatment: A comprehensive review and future perspectives
Reena Gupta, Haneen Fadhil Jasim, Zahraa Abbas Al-Khafaji, Suhas Ballal, Priya Priyadarshini Nayak, Renu Sharma and Kattela Chennakesavulu
Med Oncol, 2026, 43
DOI: 10.1007/s12032-025-03221-2

DNAzyme and controllable cholesterol stacking DNA machine integrates dual-target recognition CTCs enable homogeneous liquid biopsy of breast cancer
Weijing Liu, Yue Wang, Pengjun Jiang, Ke Huang, He Zhang, Jie Chen and Piaopiao Chen
Biosensors and Bioelectronics, 2024, 261, 116493
DOI: 10.1016/j.bios.2024.116493

Noninvasive and Spatiotemporal Control of DNAzyme-Based Imaging of Metal Ions In Vivo Using High-Intensity Focused Ultrasound
Xiaojing Wang, Gun Kim, James L. Chu, Tingjie Song, Zhenglin Yang, Weijie Guo, Xiangli Shao, Michael L. Oelze, King C. Li and Yi Lu
J. Am. Chem. Soc., 2022, 144, 5812
DOI: 10.1021/jacs.1c11543

DNA nanotechnology for next-generation biosensors: Principles, strategies, and challenges
Arooj Sarwar, Fareeha Shakeel, Tayyeba Fatima, Rashid Amin, Syeda Nayab Batool Rizvi, Tajamal Hussain and Adeel Afzal
International Journal of Biological Macromolecules, 2025, 329, 147825
DOI: 10.1016/j.ijbiomac.2025.147825

A review towards sustainable analyte detection: Biomimetic inspiration in biosensor technology
Pratistha Bhagat and Lata Sheo Bachan Upadhyay
Journal of Biotechnology, 2025, 398, 51
DOI: 10.1016/j.jbiotec.2024.11.015

MicroRNA‐Triggered Programmable DNA‐Encoded Pre‐PROTACs for Cell‐Selective and Controlled Protein Degradation
Jiayin Zhan, Xiang Li, Zhe Feng, Zheng Liu, Zhiyuan Feng, Jun‐Jie Zhu and Jingjing Zhang
Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202415323

Construction of a simple dual-mode ATP-sensing system for reliable fish freshness evaluation
Qingyang Si, Yumeng Li, Ziling Huang, Chuanyi Liu, Xiaomei Chen, Jie Wei and Fuan Wang
Analytica Chimica Acta, 2023, 1252, 341048
DOI: 10.1016/j.aca.2023.341048

Photocatalytic colorimetry/electrochemical dual-mode biosensor based on DNAzyme and SYBR Green I for the detection of lead ions in water
Meng Luo, Linshan Yang, Chengyan Yin, Zhaoxia Chen, Fangfang Sheng, Yaoxin Yang, Hao Hong and Shuxia Xu
Microchemical Journal, 2025, 212, 113355
DOI: 10.1016/j.microc.2025.113355

Enzyme-free and label-free detection of HER2 in human serum based on Ag+-released hybridization chain reaction signal amplification
Huaze Shao, Hong Yan, Qing Tang, Shiquan Zheng, Hanren Chen and Lihong Liu
Sensors and Actuators B: Chemical, 2024, 413, 135919
DOI: 10.1016/j.snb.2024.135919

Stimuli-activatable protein degraders for targeted cancer therapy: from prodrug design to nanoplatform applications
Xingyu Jiang, Yinuo Chen, Yunna Gao, Rui Rong, Yi Lai, Zheying Zhu and Zhiai Xu
Advanced Drug Delivery Reviews, 2026, 232, 115808
DOI: 10.1016/j.addr.2026.115808

Designing Nuclease‐Resistant Enzyme‐Mimicking Assemblies of Oligonucleotides Through Supramolecular Conjugation with Platinum(II) Complexes
Alisha Kamra, Rohit Kapila, Abhay Srivastava, Bhaskar Sen and Subinoy Rana
Angew Chem Int Ed, 2026, 65
DOI: 10.1002/anie.202522266

PCR‐Free Site‐Directed Mutagenesis on Repetitive Sequences Using Single‐Stranded DNA‐Assisted Double‐Stranded DNA Nicking by DNAzymes
Mingkuan Lyu, Linggen Kong, Xiangli Shao and Yi Lu
Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202509127

Enzyme- and nanozyme-based food allergen detections: from natural biocatalysts to rational engineering approaches
Shuang Wu, Jinlong Zhao, Youfa Wang, Vijaya Raghavan, Pengfei Dong, Xinxue Zhang, Jie Han, Rui Wang, Yajie Tang, Geoffrey I.N. Waterhouse and Jin Wang
Trends in Food Science & Technology, 2025, 160, 105016
DOI: 10.1016/j.tifs.2025.105016

State-of-the-art signal amplification strategies for nucleic acid and non-nucleic acid biosensors
Ijaz Gul, Muhammad Akmal Raheem, Md. Reyad-ul-Ferdous, Xi Yuan, Zhenglin Chen, Chenying lv, Minjiang Chen, Jiansong Ji, Duanpo Wu, Qiang Zhao, Chenggang Yan and Dongmei Yu
Sensors and Actuators Reports, 2025, 9, 100268
DOI: 10.1016/j.snr.2024.100268

Non-enzymatic aptazyme-driven autonomous DNA circuits coupled with three-junction CHA for amplified live-cell ATP imaging
Dan Zhu, Yang Hu, Yanting Xia, Yaqi Wei, Shuhan Lin, Jie Chao, Shao Su and Lianhui Wang
Sensors and Actuators B: Chemical, 2024, 418, 136259
DOI: 10.1016/j.snb.2024.136259

A thermal-activated peroxidase DNAzyme via G-quadruplex nanowires
Xin Yang, Yiqi Fan, Bo Yao and Fangwei Shao
Commun Chem, 2025, 8
DOI: 10.1038/s42004-025-01805-7

Label-Free and DNAzyme-Mediated Biosensor with a High Signal-to-Noise Ratio for a Lumpy Skin Disease Virus Assay
Gaihua Cao, Nannan Yang, Jun Yang, Jiali Li, Lin Wang, Fuping Nie, Danqun Huo and Changjun Hou
Anal. Chem., 2024, 96, 10927
DOI: 10.1021/acs.analchem.4c00962

Electrochemical determination of Pb2+ based on DNAzyme-triggered rolling circle amplification and DNA-templated silver nanoclusters amplification strategy
Yingqin Zhang, Ying Liao, Xuehu Yin, Yanli Zhang, Zhi Yang, Hongbin Wang, Wenrong Yang and Pengfei Pang
Microchemical Journal, 2023, 189, 108544
DOI: 10.1016/j.microc.2023.108544

A Novel DNAzyme Walker Biosensor for the Determination of Chromium(III)
Xu Chen, Lelin Qian and Juan Zhang
Analytical Letters, 2025, 58, 1906
DOI: 10.1080/00032719.2024.2395411

A glucose/oxygen biofuel cell integrated with a triple-helix molecular switch for sensitive self-powered detection of ATP
Jingxi Yue, Hong Zhou, Wenfang Deng, Yueming Tan and Qingji Xie
Sensors and Actuators B: Chemical, 2025, 444, 138506
DOI: 10.1016/j.snb.2025.138506

Nucleic Acids Enabled‐Interfacial Engineering for Biomarker Sensing with Distance Constraint Effects
Lu Wang, Shuqi Tang, Lin Li, Kaifei Jin, Xiyue Xie, Yuhua Chen, Kaiyong Cai and Jixi Zhang
Advanced Sensor Research, 2023, 2
DOI: 10.1002/adsr.202200062

Assembly of Dynamic Gated and Cascaded Transient DNAzyme Networks
Jiantong Dong, Yu Ouyang, Jianbang Wang, Michael P. O’Hagan and Itamar Willner
ACS Nano, 2022, 16, 6153
DOI: 10.1021/acsnano.1c11631

Interfacing DNA and Aptamers with Gold Nanoparticles: From Fundamental Colloid and Interface Sciences to Biosensors
Yuzhe Ding and Juewen Liu
Chin. J. Chem., 2024, 42, 2391
DOI: 10.1002/cjoc.202400113

Bridging Target Recognition with Direct Molecular Counting: A DNA Framework Converter-Mediated nFCM Assay Platform for Quantifying Diverse Biochemical Analytes
Su Zhou, Qin Li, Hongrong Yan, Zixuan Xiao, Luyou Liu, Jin Li and Fengli Qu
Anal. Chem., 2026, 98, 7888
DOI: 10.1021/acs.analchem.6c00495

A Connected World: System-Level Support Through Biosensors
Eric S. McLamore and Shoumen P.A. Datta
Annual Rev. Anal. Chem., 2023, 16, 285
DOI: 10.1146/annurev-anchem-100322-040914

Integration of click ligation chain reaction with split DNAzyme for enzyme-free cascade amplification and ultrasensitive nucleic acid detection
Fan Wang, Chenglong Bao, Susu Cui, Yongsheng Yu and Weiwei Yang
Sensors and Actuators B: Chemical, 2026, 453, 139550
DOI: 10.1016/j.snb.2026.139550

Bottom‐up DNA nanostructure‐based paper as point‐of‐care diagnostic: From method to device
Xueping Gao, Liu Feng, Ruijia Deng, Binpan Wang, Yuan He, Ligai Zhang, Dan Luo, Ming Chen and Kai Chang
Interdisciplinary Medicine, 2024, 2
DOI: 10.1002/INMD.20230033

Subcellular Compartment‐Specific Amplified Imaging of Metal Ions via Ribosomal RNA‐Regulated DNAzyme Sensors
Deyu Yi, Lele Li and Mengyuan Li
Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202412387

Effective multicolor visual biosensor for ochratoxin A detection enabled by DNAzyme catalysis and gold nanorod etching
Zhiqiang Guo, Mingshuo Zhang, Haiping Zhang, Xinru Ren, Yijing Xiao, Weiqing Sun, Yu Wang, Su Liu and Jiadong Huang
Microchim Acta, 2025, 192
DOI: 10.1007/s00604-024-06883-3

Harnessing thiophilic cadmium to enhance 8–17 DNAzyme activity in cascade oligo biosensors
Mohammad Sadraeian, Reza Maleki, Libing Fu, Gungun Lin, Jiajia Zhou, Dayong Jin and Jeffrey R. Reimers
Biosensors and Bioelectronics, 2025, 288, 117816
DOI: 10.1016/j.bios.2025.117816

Integration of RCA-Based DNA Nanoscaffold with Target Triggered RNA-Cleaving DNAzyme for Sensitive Detection of miRNA21
Yuan Li, Xuefei Lv, Hao Jiang, Xiaoqiong Li and Yulin Deng
Appl Biochem Biotechnol, 2024, 196, 8925
DOI: 10.1007/s12010-024-05022-1

DNAzyme assisted single amplification for FEN1 activity detection using a personal glucose meter
Mingxi Li, Weijie Zang, Shuiliang Wang, Zhannuo Lin, Shu Liu, Yiling Chen, Xiaohui Ruan, Yuanfang Luo, Chao Xing and Chunhua Lu
Analytica Chimica Acta, 2025, 1336, 343495
DOI: 10.1016/j.aca.2024.343495

In Vitro Selection and Characterization of a DNAzyme Probe for Diverse Pathogenic Strains of Clostridium difficile
Shuwen Qian, Dingran Chang, Jimmy Gu, Bruno J. Salena and Yingfu Li
Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202300240

Rational Design Strategies for Stimuli‐Responsive DNAzymes Using Modified and Artificial Nucleotides
Yusuke Takezawa and Mitsuhiko Shionoya
Chemistry A European J, 2026, 32
DOI: 10.1002/chem.202503570

Modulation of DNAzyme Activity via Butanol Dehydration
Yuqing Li, Mohamad Zandieh and Juewen Liu
Chemistry — An Asian Journal, 2021, 16, 4062
DOI: 10.1002/asia.202101091

CircRNA knockout/knockdown tools in molecular biology research
Yujie Chang and Junyao Ding
Biochemical and Biophysical Research Communications, 2025, 783, 152607
DOI: 10.1016/j.bbrc.2025.152607

Biosensing using DNA-based structures integrated with nanosheets
Elnaz Ahmadi-Sangachin, Fatima Bazzi, Guobao Xu and Morteza Hosseini
Microchemical Journal, 2023, 191, 108779
DOI: 10.1016/j.microc.2023.108779

Engineering nucleic acid functional probes in neuroimaging
Tianqi Xu, Feng Jia, Hua Cui, Min Li, Fan Li, Xiaohua Zhang and Xiaolei Zuo
TrAC Trends in Analytical Chemistry, 2022, 154, 116651
DOI: 10.1016/j.trac.2022.116651

DNAzyme-based ultrasensitive immunoassay: Recent advances and emerging trends
Meng Wang, Zhe Liu, Chang Liu, Wanghong He, Dui Qin and Minli You
Biosensors and Bioelectronics, 2024, 251, 116122
DOI: 10.1016/j.bios.2024.116122

Unnatural Amino Acid and Emerging Chemistry Approaches to Map RNA–Protein Interactions
Eryn Lundrigan, Parrish Evers, Elexa Scott and John Paul Pezacki
Angew Chem Int Ed, 2026, 65
DOI: 10.1002/anie.202520744

Deoxyribonucleic acid-guided dual-mode electro-chemical/chemiluminescent platform for sensitive and selective examination of Pb2+
Kaiyue Hu, Lingxia Qin, Xinxin Ren, Zhiyong Guo, Sui Wang and Yufang Hu
Journal of Electroanalytical Chemistry, 2022, 922, 116757
DOI: 10.1016/j.jelechem.2022.116757

Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme
Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang and Fangfu Ye
Bioactive Materials, 2023, 23, 45
DOI: 10.1016/j.bioactmat.2022.10.002

Dual Signal Amplification by Urease Catalysis and Silver Nanoparticles for Ultrasensitive Colorimetric Detection of Nucleic Acids
Jialin Sai, Lu Zhou, Lin Jiang, Dongguo Xue, Renjun Pei, Aihua Liu and Lijun Xu
Anal. Chem., 2023, 95, 11359
DOI: 10.1021/acs.analchem.3c01483

Modular Weaving DNAzyme in Skeleton of DNA Nanocages for Photoactivatable Catalytic Activity Regulation
Hengzhi Zhao, Deyu Yi, Lele Li, Yuliang Zhao and Mengyuan Li
Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202404064

PfAgo-DNAzyme cascade amplification improves Salmonella typhimurium detection
Bingjie Zheng, Yuqing Qin, Yanyan Chai, Aizhen Guo and Yonggang Hu
Biosensors and Bioelectronics, 2025, 289, 117895
DOI: 10.1016/j.bios.2025.117895

Functional nucleic acids as modular components against SARS-CoV-2: From diagnosis to therapeutics
Wenxian Zhang, Na Liu and Jingjing Zhang
Biosensors and Bioelectronics, 2022, 201, 113944
DOI: 10.1016/j.bios.2021.113944

Upconversion Luminescence‐Boosted Escape of DNAzyme from Endosomes for Enhanced Gene‐Silencing Efficacy
Yaoxuan Chen, Rupeng Zhao, Lele Li and Yuliang Zhao
Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202206485

An Enzymatically Gated Catalytic Hairpin Assembly Delivered by Lipid Nanoparticles for the Tumor‐Specific Activation of Signal Amplification in miRNA Imaging
Qing Liu, Yuanyu Huang, Zhengping Li, Lele Li, Yuliang Zhao and Mengyuan Li
Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202214230

Smart Free-Standing Bilayer Polyacrylamide/DNA Hybrid Hydrogel Film-Based Sensing System Using Changes in Bending Angles as a Visual Signal Readout
Mengyuan Yin, Yaxing Zhang, Hanxue Liang, Chang Liu, Yanhui Bi, Juanjuan Sun and Weiwei Guo
Anal. Chem., 2024, 96, 5215
DOI: 10.1021/acs.analchem.3c05562

Cleavage of Structured RNAs Is Accelerated by High Affinity DNAzyme Agents
Dmitry M. Kolpashchikov and Yulia V. Gerasimova
ChemBioChem, 2025, 26
DOI: 10.1002/cbic.202400950

Rapid Detection of Staphylococcus aureus in Milk Samples by DNA Nanodendrimer-Based Fluorescent Biosensor
Mukaddas Mijit, Dongxia Pan, Hui Wang, Chaoqun Sun and Liang Yang
Biosensors, 2025, 15, 527
DOI: 10.3390/bios15080527

A CpG methylation-powered dynamic three-dimensional-DNAzyme walker for single-molecule monitoring of multiple cytosine-C5 methyltransferases
Huimin Yuan, Shi Wang, Li-juan Wang and Chun-yang Zhang
Sensors and Actuators B: Chemical, 2023, 390, 133959
DOI: 10.1016/j.snb.2023.133959

Smart Nucleic Acid Hydrogel-Based Biosensors: From Molecular Recognition and Responsive Mechanisms to Applications
Lu Xu, Longjiao Zhu, Xiaoyu Wang, Wenqiang Zhang, Xiaoyun He, Yangzi Zhang and Wentao Xu
Biosensors, 2025, 15, 799
DOI: 10.3390/bios15120799

Investigation of the DNA Methylation-Modified 8–17 DNAzyme Functions via Sensitive Catalytic Hairpin Self-Assembly Reaction
Wanxue Wang, Guoying Li, Xinghui Zhou, Xiaofang Ding, Feng Zhang, Yaoyao Shu, Yanqiong Liu, Haiou Ma, Lang Zhang and Danping Chen
ACS Sens., 2025, 10, 4371
DOI: 10.1021/acssensors.5c00581

Recent progress in DNAzyme-mediated CRISPR/Cas systems for the detection of non-nucleic acid targets
Hewa Jalal Azeez, Jabar Kamal Mirza Abdalla, Amer Khaleel, Reza Mahmoudi Lamouki, Armin Gharibi and Esmaeil Babaei
Microchemical Journal, 2025, 216, 114836
DOI: 10.1016/j.microc.2025.114836

A Programmable DNAzyme for the Sensitive Detection of Nucleic Acids
Chenzhi Shi, Donglei Yang, Xiaowei Ma, Li Pan, Yuanchuan Shao, Gaurav Arya, Yonggang Ke, Chuan Zhang, Fuan Wang, Xiaolei Zuo, Min Li and Pengfei Wang
Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202320179

Luminescent Lanthanides in Biorelated Applications: From Molecules to Nanoparticles and Diagnostic Probes to Therapeutics
Carlson Alexander, Zhilin Guo, Peter B. Glover, Stephen Faulkner and Zoe Pikramenou
Chem. Rev., 2025, 125, 2269
DOI: 10.1021/acs.chemrev.4c00615

A DNAzyme Cooperative Platform for the Highly Sensitive Detection of Vibrio Parahaemolyticus
Anyi Li, Xi Zhang, Xiufen Yang, Bo Ling, Yi Shen, Daoyun Peng, Miaoyu Tang, Sicheng Li, Yunusov Khaydar Ergashovich, Rodrigo Ledesma-Amaro, Buhua Wang and Yi Wan
Sensors and Actuators B: Chemical, 2026, 139899
DOI: 10.1016/j.snb.2026.139899

Integration of isothermal amplification methods in DNA hydrogels for biosensing
Kawthar Abdallah, Morteza Hosseini, Yasaman-Sadat Borghei, Jiuxing Li and Bijan Ranjbar
TrAC Trends in Analytical Chemistry, 2025, 193, 118452
DOI: 10.1016/j.trac.2025.118452

Biosensors based on functional nucleic acids and isothermal amplification techniques
Xiuen Cao, Chuanpin Chen and Qubo Zhu
Talanta, 2023, 253, 123977
DOI: 10.1016/j.talanta.2022.123977

Controllable self-assembled DNA nanomachine enable homogeneous rapid electrochemical one-pot assay of lung cancer circulating tumor cells
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen and Feng Lin
Biosensors and Bioelectronics, 2024, 246, 115865
DOI: 10.1016/j.bios.2023.115865

Development of Nucleic‐Acid‐Based Electrochemical Biosensors for Clinical Applications
Zijie Zhang, Payel Sen, Bal Ram Adhikari, Yingfu Li and Leyla Soleymani
Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202212496

SERS-Based AND Logic Gate for Monitoring Signal Transduction of Specific Cancer Cells and Evaluating Antitumor Efficacy via Imaging of Membrane Protein Dimerization
Xiaoyuhao Jin, Chen Dong, Tingxiao Wang, Jingjing Zhang, Jian Liu, Xiyu He, Lianhui Wang and Chunyuan Song
Anal. Chem., 2025, 97, 23927
DOI: 10.1021/acs.analchem.5c03545

In Vitro Selection of M2+-Independent, Fast-Responding Acidic Deoxyribozymes for Bacterial Detection
Qinbin Zhou, Guangxiao Zhang, Yunping Wu, Qiang Zhang, Yi Liu, Yangyang Chang and Meng Liu
J. Am. Chem. Soc., 2023, 145, 21370
DOI: 10.1021/jacs.3c06155

Simultaneous Imaging of Cu+ and Cu2+ in Neural Cells Using DNAzyme Probes Reveals Mechanistic Link Between Copper Redox Imbalance and Amyloid Pathology
Xiangli Shao, Zhenglin Yang, Zhihao Xu, Weijie Guo, Whitney Lewis, Boyi Gan and Yi Lu
Angew Chem Int Ed, 2026, 65
DOI: 10.1002/anie.202524237

A Chemical Tool for Guiding Li Therapy
Ankona Datta
ACS Cent. Sci., 2021, 7, 1783
DOI: 10.1021/acscentsci.1c01289

Biosensors and lateral flow immunoassays: Current state and future prospects
Raveena Udhani, Charmy Kothari and Sunny Kumar
Clinica Chimica Acta, 2025, 574, 120272
DOI: 10.1016/j.cca.2025.120272

The 10–23 DNAzyme in Biosensing and Diagnostics: Applications, Challenges, and Future Directions
Connor Nurmi, Jake Brill, Sanne Roumans, Amal Mathai, John D. Brennan and Yingfu Li
Angewandte Chemie, 2026
DOI: 10.1002/ange.7876181

Biomarkers for Cancer: A Detail Review
Ritesh Bhole, Pravin Bhondave, Rupesh Chikhale, Chandrakant Bonde and Shailendra Gurav
Fr. Ukr. J. Chem., 2023, 11, 30
DOI: 10.17721/fujcV11I1P30-59

Functional nucleic acid-based fluorescence imaging for tumor microenvironment monitoring: A review
Zuoxiang Liang and Fengyu Tian
Analytica Chimica Acta, 2025, 1350, 343794
DOI: 10.1016/j.aca.2025.343794

Engineering rigid triplex-forming oligonucleotide structure for DNAzyme-mediated ratiometric electrochemical biosensing of microcystin-LR
Yiming Yang, Chengxi Zhu, Na Dong, Shuda Liu, Shuyun Meng, Wenjia Li, Dong Liu and Tianyan You
Sensors and Actuators B: Chemical, 2026, 450, 139256
DOI: 10.1016/j.snb.2025.139256

Chiral ZnO Nanostructures with Chiral-Induced Spin Selectivity-Induced Spin Polarization for Ultrasensitive Photoelectrochemical DNA Detection
Haiying Xu, Yunxue Zhang, Mengting Zhou, Shan Yao, Yanfeng Lv, Shuang Zhou, Kang Cui, Yan Zhang, Jing Zhang and Mei Yan
Anal. Chem., 2026
DOI: 10.1021/acs.analchem.6c00229

Modular Engineering of the DNAzyme-Based Electrochemiluminescence Biosensor with the Nitrogen and Sulfur Codoped Carbon Dots as Near-Infrared Emitters for MicroRNA detection
Haonan He, Benting Xie, Shuang Li, Hejun Gao, Juan Zhang, Hongquan Fu and Yunwen Liao
Anal. Chem., 2025, 97, 9902
DOI: 10.1021/acs.analchem.5c00522

Nucleotides Entrapped in Liposome Nanovesicles as Tools for Therapeutic and Diagnostic Use in Biomedical Applications
Camila Magalhães Cardador, Luis Alexandre Muehlmann, Cíntia Marques Coelho, Luciano Paulino Silva, Aisel Valle Garay, Alexandra Maria dos Santos Carvalho, Izabela Marques Dourado Bastos and João Paulo Figueiró Longo
Pharmaceutics, 2023, 15, 873
DOI: 10.3390/pharmaceutics15030873

Single-Cell Liquid Biopsy of Lung Cancer: Ultra-Simplified Efficient Enrichment of Circulating Tumor Cells and Hand-Held Fluorometer Portable Testing
Yaqin He, Zixuan Zhan, Li Yan, Chengyong Wu, Yue Wang, Congcong Shen, Ke Huang, Zeliang Wei, Feng Lin, Binwu Ying, Weimin Li and Piaopiao Chen
ACS Nano, 2024, 18, 5017
DOI: 10.1021/acsnano.3c11147

Smart Hairpins@MnO2 Nanosystem Enables Target-Triggered Enzyme-Free Exponential Amplification for Ultrasensitive Imaging of Intracellular MicroRNAs in Living Cells
Zizhong Yang, Birong Liu, Ting Huang, Bao-Ping Xie, Wen-Jun Duan, Min-Min Li, Jin-Xiang Chen, Jun Chen and Zong Dai
Anal. Chem., 2022, 94, 8014
DOI: 10.1021/acs.analchem.2c01211

Exploration and Application of the Catalytic Superiority of Non-G-Quadruplex Hemin Aptamers
Changjiang Li, Xiaolong Li, Shengqi Wei and Tongbo Wu
Anal. Chem., 2025, 97, 3680
DOI: 10.1021/acs.analchem.4c06315

Making target sites in large structured RNAs accessible to RNA-cleaving DNAzymes through hybridization with synthetic DNA oligonucleotides
Connor Nurmi, Jimmy Gu, Amal Mathai, John D Brennan and Yingfu Li
Nucleic Acids Research, 2024, 52, 11177
DOI: 10.1093/nar/gkae778

Nucleic acid-assisted CRISPR-Cas systems for advanced biosensing and bioimaging
Siyu Chen, Bo Gong, Cong Zhu, Chunyang Lei and Zhou Nie
TrAC Trends in Analytical Chemistry, 2023, 159, 116931
DOI: 10.1016/j.trac.2023.116931

Site‐Specific Recognition of Inosine‐Modified RNA by Deoxyribozyme with Distant Cleavage Site
Shusen Xiao, Yangyang Chang, Pan Jia, Xiaoqian Li, Xia Li, Xiaozheng Li, Hong Yuan, Jiuxing Li, Zijie Zhang and Meng Liu
Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202513587

A Fluorogenic DNAzyme for A Thermally Stable Protein Biomarker from Fusobacterium nucleatum, a Human Bacterial Pathogen
Qian Feng, Sandy Zakaria, Devon Morrison, Kha Tram, Jim Gu, Bruno J. Salena and Yingfu Li
Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202306272

Recent Developments in Amyloid‐Based Electronic Materials: From Molecular Engineering to Biotechnology
Viraj Singhal and Santu Bera
ChemNanoMat, 2026, 12
DOI: 10.1002/cnma.202500630

Circular DNAzyme-Switched CRISPR/Cas12a Assay for Electrochemiluminescent Response of Demethylase Activity
Wei-Wei Yang, Mei-Ling Zhao, Mei-Ling Liu, Wen-Bin Liang, Xia Zhong and Ying Zhuo
ACS Sens., 2024, 9, 344
DOI: 10.1021/acssensors.3c02025

A fluorescent assay for alkaline phosphatase activity based on phosphorylation protection and DNAzyme-assisted amplification
Yan Wang, Zhenwei Tang, Xueling Shang, Ying Yan, Xinying Xiang and Changbei Ma
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 279, 121398
DOI: 10.1016/j.saa.2022.121398

Catalytic hairpin self-assembly for biosensing: Classification, influencing factors, and applications
Luyang Zhao, Yang Song and Hengyi Xu
TrAC Trends in Analytical Chemistry, 2024, 171, 117508
DOI: 10.1016/j.trac.2023.117508

Highly sensitive and selective demethylase FTO detection using a DNAzyme-mediated CRISPR/Cas12a signal cascade amplification electrochemiluminescence biosensor with C–CN/PCNV heterojunction as emitter
Hong Li, Shuai Qiao, Heng Zhang, Yanxia Qiao, Jin Liu and Yan Li
Biosensors and Bioelectronics, 2024, 256, 116276
DOI: 10.1016/j.bios.2024.116276

Solving Mazes of Organelle‐Targeted Therapies with DNA Nanomachines
Muhammad Umar Farooq, Charles H. Lawrie and Nan‐Nan Deng
Advanced Materials, 2025, 37
DOI: 10.1002/adma.202508047

Upconverting nanoparticles based nanodevice for DNAzymes amplified miRNAs detection and artificially controlled chemo-gene therapy
Yanmei Zhou, Wenxiao Ma, Ruijiao Sun, Bo Liu, Xiaoru Zhang and Hongsheng Yang
Biosensors and Bioelectronics, 2022, 214, 114549
DOI: 10.1016/j.bios.2022.114549

Aptamer and DNAzyme Based Colorimetric Biosensors for Pathogen Detection
Rudi Liu, Jiuxing Li, Bruno J. Salena and Yingfu Li
Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202418725

Ultrasensitive detection of cancer-associated nucleic acids and mutations by primer exchange reaction-based signal amplification and flow cytometry
Samet Kocabey, Sarah Cattin, Isabelle Gray and Curzio Rüegg
Biosensors and Bioelectronics, 2025, 267, 116839
DOI: 10.1016/j.bios.2024.116839

Advancing DNAzyme Technology in Tumor Treatment
Jiancheng Peng, Nini Wang, Rong Xu, Haiming Fan and Yuan He
Catalysts, 2024, 14, 795
DOI: 10.3390/catal14110795

Signal Transduction Strategies for DNAzyme-Based Sensing and Imaging of Metal Ions in Cells and in Vivo
Whitney Lewis, Annie Farrell, Shreestika Pradhan and Yi Lu
Chemical & Biomedical Imaging, 2025, 3, 473
DOI: 10.1021/cbmi.4c00090

A DNA-MOF hybrid nanosystem for prediction of photodynamic therapy efficacy via amplified imaging of apoptotic mRNA
Chaowang Li, Deyu Yi, Mengyuan Li and Zhengping Li
Nano Today, 2025, 65, 102837
DOI: 10.1016/j.nantod.2025.102837

Crispr-Dnazyme Tandem Assay for Sensitive Analysis of Lead Contamination and Bioaccumulation in Mice
Hao Yang, Ting Xue, Xuhan Xia, Hong Gao, Yi Dong, Wenhu Zhou, Yi Wan and Ruijie Deng
SSRN Journal, 2022
DOI: 10.2139/ssrn.4115151

Double-Tetrahedral DNA Probe Functionalized Ag Nanorod Biointerface for Effective Capture, Highly Sensitive Detection, and Nondestructive Release of Circulating Tumor Cells
Jinxiang Li, Yugang Yuan, Hongyu Gan, Chen Dong, Bin Cao, Jin-liang Ni, Xueliang Li, Wenjie Gu, Chunyuan Song and Lianhui Wang
ACS Appl. Mater. Interfaces, 2022, 14, 32869
DOI: 10.1021/acsami.2c06005

Recent Advancements in Nanosystem-Based Molecular Beacons for RNA Detection and Imaging
Geng Yang, Ting Song, Meng Wang, Mengyue Li, QingQing Su, Zhengxin Xie, Xiaoxue Xie, Hanxi Zhang, Yi Feng, Chunhui Wu, Yiyao Liu and Hong Yang
ACS Appl. Nano Mater., 2022, 5, 3065
DOI: 10.1021/acsanm.1c03966

P-Doped Cu–N–C Single-Atom Catalysts Boost Cathodic Electrochemiluminescence of Luminol for MicroRNA-320d Detection
Ruifang Liu, Shujing Wang, Longfei Zhu, Chengxiang Li, Li Xie, Jinxiang Wu, Shenguang Ge and Jinghua Yu
Anal. Chem., 2025, 97, 20343
DOI: 10.1021/acs.analchem.5c03547

Recent Advance in Sensitive Detection of Demethylase FTO
Min Shang, Jingying Qin, Bingyue Zhao, Qian Luo, Huimin Wang, Changying Yang, Hanghang Liu, Jiabing Ran and Wei Yang
ChemBioChem, 2025, 26
DOI: 10.1002/cbic.202400995

Emerging strategies for food contaminant detection via DNAzyme-driven DNA walker platforms: Strategies, applications, and future perspectives
Abdelgadir Altoum, Ammar Yasir Ahmed, Zainb A. Talib, I.B. Sapaev, Muhammad Shahid Iqbal, Ashish singh Chauhan, Renu Sharma, Rajashree Panigrahi, Vimal Arora and Ankit Oza
Talanta, 2026, 305, 129623
DOI: 10.1016/j.talanta.2026.129623

Fluorescence assay for aflatoxin B1 based on aptamer-binding triggered DNAzyme activity
Qiuyi Cheng and Qiang Zhao
Anal Bioanal Chem, 2024, 416, 6367
DOI: 10.1007/s00216-024-05523-2

Enhancing CAR-T Cell Therapy with Functional Nucleic Acids
Bruktawit Maru, Lea Nadeau and Maureen McKeague
ACS Pharmacol. Transl. Sci., 2021, 4, 1716
DOI: 10.1021/acsptsci.1c00188

Biomolecule-responsive nanoprobes for living cell analysis
Ji Zheng, Xiaoxing Fang, Liping Li, Ruiping Zhang and Chao Li
TrAC Trends in Analytical Chemistry, 2023, 169, 117387
DOI: 10.1016/j.trac.2023.117387

DNAzyme Nanoconstruct-Integrated Autonomously-Adaptive Coatings Enhance Titanium-Implant Osteointegration by Cooperative Angiogenesis and Vessel Remodeling
Maohua Chen, Menghuan Li, Xijiao Ren, Fei Zhou, Yanan Li, Lu Tan, Zhong Luo, Kaiyong Cai and Yan Hu
ACS Nano, 2023, 17, 15942
DOI: 10.1021/acsnano.3c04049

A Versatile DNAzyme‐Amplified Protease‐Sensing Platform for Accurate Diagnosis of SARS‐CoV‐2 and Reliable Classification of Colorectal Cancer
Benrui Weng, Yifei Wang, Qingqing Zhang, Yuqian Jiang, Jinhua Shang, Xiaoqing Liu and Fuan Wang
Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202507241

Fluorescent biosensor for lead ion detection based on GR-5 DNAzyme and self-hybridization chain reaction
Min Li, Huanxi Chen, Yu Zhang, Yuxin Cheng, Fengyi Lin, Haibo Wang and Jianyuan Dai
Analytica Chimica Acta, 2025, 1344, 343712
DOI: 10.1016/j.aca.2025.343712

DNA Nanotechnology Targeting Mitochondria: From Subcellular Molecular Imaging to Tailor‐Made Therapeutics
Fangzhi Yu, Xiangfei Li, Chuangui Sheng and Lele Li
Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202409351