Maurice A. Marsini, Frederic G. Buono, Jon C. Lorenz, Bing-Shiou Yang, Jonathan T. Reeves, Kanwar Sidhu, Max Sarvestani, Zhulin Tan, Yongda Zhang, Ning Li, Heewon Lee, Jason Brazzillo, Laurence J. Nummy, J. C. Chung, Irungu K. Luvaga, Bikshandarkoil A. Narayanan, Xudong Wei, Jinhua J. Song, Frank Roschangar, Nathan K. Yee and Chris H. Senanayake

Green Chem., 2017, 19, 1454
DOI: 10.1039/C6GC03123D

Ni@C catalyzed hydrogenation of acetophenone to phenylethanol under industrial mild conditions in a flow reactor

Shanshan Lin, Jianguo Liu and Longlong Ma

React. Chem. Eng., 2022, 7, 1126
DOI: 10.1039/D1RE00513H

Self-optimising processes and real-time-optimisation of organic syntheses in a microreactor system using Nelder–Mead and design of experiments

Verena Fath, Norbert Kockmann, Jürgen Otto and Thorsten Röder

React. Chem. Eng., 2020, 5, 1281
DOI: 10.1039/D0RE00081G

Unlocking geminal fluorohaloalkanes in nucleophilic fluoroalkylation chemistry: generation and trapping of lithiumfluorocarbenoids enabled by flow microreactors

Mauro Spennacchio, Marco Colella, Michael Andresini, Roberta Savina Dibenedetto, Elena Graziano, Andrea Aramini, Leonardo Degennaro and Renzo Luisi

Chem. Commun., 2023, 59, 1373
DOI: 10.1039/D2CC06717J

Non-aqueous continuous-flow electrophoresis (NACFE): potential separation complement for continuous-flow organic synthesis

Nikita A. Ivanov, Yimo Liu, Sven Kochmann and Sergey N. Krylov

Lab Chip, 2019, 19, 2156
DOI: 10.1039/C9LC00460B

Development of a novel electrochemical carboxylation system using a microreactor

Hiroyuki Tateno, Yoshimasa Matsumura, Koji Nakabayashi, Hisanori Senboku and Mahito Atobe

RSC Adv., 2015, 5, 98721
DOI: 10.1039/C5RA19289G

Electrosynthesis of new quinone sulfonimide derivatives using a conventional batch and a new electrolyte-free flow cell

Shima Momeni and Davood Nematollahi

Green Chem., 2018, 20, 4036
DOI: 10.1039/C8GC01727A

Hierarchical silica monoliths with submicron macropores as continuous-flow microreactors for reaction kinetic and mechanistic studies in heterogeneous catalysis

Richard Kohns, Christian P. Haas, Alexandra Höltzel, Christian Splith, Dirk Enke and Ulrich Tallarek

React. Chem. Eng., 2018, 3, 353
DOI: 10.1039/C8RE00037A

Development of a flow process for an easy and fast access to 2-pyrone derivatives

Grazia Isa C. Righetti, Francesca Tentori, Elisabetta Brenna and Cristian Gambarotti

React. Chem. Eng., 2023, 8, 199
DOI: 10.1039/D2RE00312K

A multistep continuous flow synthesis machine for the preparation of pyrazolesviaa metal-free amine-redox process

Jian-Siang Poh, Duncan L. Browne and Steven V. Ley

React. Chem. Eng., 2016, 1, 101
DOI: 10.1039/C5RE00082C

A field guide to flow chemistry for synthetic organic chemists

Luca Capaldo, Zhenghui Wen and Timothy Noël

Chem. Sci., 2023, 14, 4230
DOI: 10.1039/D3SC00992K

Accelerating innovation in peptide synthesis through continuous-flow

Shinichiro Fuse

Org. Biomol. Chem., 2025, 23, 10628
DOI: 10.1039/D5OB01553G

Continuous flow synthesis of ordered porous materials: from zeolites to metal–organic frameworks and mesoporous silica

Zhendong Liu, Jie Zhu, Ce Peng, Toru Wakihara and Tatsuya Okubo

React. Chem. Eng., 2019, 4, 1699
DOI: 10.1039/C9RE00142E

Continuous flow synthesis of functionalized biaryl compounds via a benzyne intermediate

Chaoming Liang, Weixia Lin, Zilong Lin, Runxiang Yu, Yuyan Kang, Xiangmin Sang, Maolin Sun, Yueyue Ma, Ruihua Cheng and Jinxing Ye

React. Chem. Eng., 2025, 10, 1359
DOI: 10.1039/D5RE00023H

Thermal characterization of highly exothermic flash chemistry in a continuous flow calorimeter

Gang Fu, Juncheng Jiang, Christopher A. Hone and C. Oliver Kappe

React. Chem. Eng., 2023, 8, 577
DOI: 10.1039/D2RE00439A

Rapid and column-chromatography-free peptide chain elongation via a one-flow, three-component coupling approach

Naoto Sugisawa, Akira Ando and Shinichiro Fuse

Chem. Sci., 2023, 14, 6986
DOI: 10.1039/D3SC01333B

Flash chemistry enables high productivity metalation-substitution of 5-alkyltetrazoles

Jeff Y. F. Wong, Christopher G. Thomson, Filipe Vilela and Graeme Barker

Chem. Sci., 2021, 12, 13413
DOI: 10.1039/D1SC04176B

Bayesian optimization for chemical reactions

Stefan Desimpel, Matthieu Dorbec, Kevin M. Van Geem and Christian V. Stevens

Chem. Soc. Rev., 2026, 55, 2731
DOI: 10.1039/D5CS00962F

Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow

Simeng Wang, Jenny-Lee Panayides, Darren Riley, Christopher J. Tighe, Klaus Hellgardt, King Kuok (Mimi) Hii and Philip W. Miller

React. Chem. Eng., 2021, 6, 2018
DOI: 10.1039/D1RE00343G

Enantioselective reaction monitoring utilizing two-dimensional heart-cut liquid chromatography on an integrated microfluidic chip

Carsten Lotter, Elisabeth Poehler, Josef J. Heiland, Laura Mauritz and Detlev Belder

Lab Chip, 2016, 16, 4648
DOI: 10.1039/C6LC01138A

Continuous-flow synthesis of cyclic carbonates with polymer-supported imidazolium-based ionic liquid (Im-PSIL) catalysts

Zhibo Yu, Haruro Ishitani and Shu Kobayashi

Green Chem., 2024, 26, 11548
DOI: 10.1039/D4GC04499A

Benzyllithiums bearing aldehyde carbonyl groups. A flash chemistry approach

Aiichiro Nagaki, Yuta Tsuchihashi, Suguru Haraki and Jun-ichi Yoshida

Org. Biomol. Chem., 2015, 13, 7140
DOI: 10.1039/C5OB00958H

Revisiting aromatic diazotization and aryl diazonium salts in continuous flow: highlighted research during 2001–2021

Jianli Chen, Xiaoxuan Xie, Jiming Liu, Zhiqun Yu and Weike Su

React. Chem. Eng., 2022, 7, 1247
DOI: 10.1039/D2RE00001F

Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives

Mariëlle M. E. Delville, Kaspar Koch, Jan C. M. van Hest and Floris P. J. T. Rutjes

Org. Biomol. Chem., 2015, 13, 1634
DOI: 10.1039/C4OB02128B

Reaction screening and optimization of continuous-flow atropine synthesis by preparative electrospray mass spectrometry

Caitlin E. Falcone, Zinia Jaman, Michael Wleklinski, Andy Koswara, David H. Thompson and R. Graham Cooks

Analyst, 2017, 142, 2836
DOI: 10.1039/C7AN00622E

Switching between P-acylation and O-acylation of H-phosphonates with chloroformates by changing acyl pyridinium and acyl ammonium ions in a microflow reactor

Hiroshi Kitamura, Yuma Tanaka and Shinichiro Fuse

Chem. Commun., 2024, 60, 10874
DOI: 10.1039/D4CC02871F

Continuous flow synthesis of the URAT1 inhibitor lesinurad

Mariana C. F. C. B. Damião, Henrique M. Marçon and Julio Cezar Pastre

React. Chem. Eng., 2020, 5, 865
DOI: 10.1039/C9RE00483A

PDMS-based turbulent microfluidic mixer

Jae Bem You, Kyowon Kang, Thanh Tinh Tran, Hongkeun Park, Wook Ryol Hwang, Ju Min Kim and Sung Gap Im

Lab Chip, 2015, 15, 1727
DOI: 10.1039/C5LC00070J

Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

Cloudius R. Sagandira, Sinazo Nqeketo, Kanyisile Mhlana, Thembela Sonti, Sibongiseni Gaqa and Paul Watts

React. Chem. Eng., 2022, 7, 214
DOI: 10.1039/D1RE00483B

A numbering-up metal microreactor for the high-throughput production of a commercial drug by copper catalysis

Gwang-Noh Ahn, Taejong Yu, Hyune-Jea Lee, Ki-Won Gyak, Ji-Ho Kang, Donghyun You and Dong-Pyo Kim

Lab Chip, 2019, 19, 3535
DOI: 10.1039/C9LC00764D

Investigation of Petasis and Ugi reactions in series in an automated microreactor system

Norbert Heublein, Jason S. Moore, Christopher D. Smith and Klavs F. Jensen

RSC Adv., 2014, 4, 63627
DOI: 10.1039/C4RA13626H

How to approach flow chemistry

Mara Guidi, Peter H. Seeberger and Kerry Gilmore

Chem. Soc. Rev., 2020, 49, 8910
DOI: 10.1039/C9CS00832B

Synthesis of ketones via organolithium addition to acid chlorides using continuous flow chemistry

Soo-Yeon Moon, Seo-Hee Jung, U. Bin Kim and Won-Suk Kim

RSC Adv., 2015, 5, 79385
DOI: 10.1039/C5RA14890A

Design of a novel dual function membrane microreactor for liquid–liquid–liquid phase transfer catalysed reaction: selective synthesis of 1-naphthyl glycidyl ether

Nikhil H. Margi and Ganapati D. Yadav

React. Chem. Eng., 2021, 6, 858
DOI: 10.1039/D1RE00030F

Modern advancements in continuous-flow aided kinetic analysis

Connor J. Taylor, Jamie A. Manson, Graeme Clemens, Brian A. Taylor, Thomas W. Chamberlain and Richard A. Bourne

React. Chem. Eng., 2022, 7, 1037
DOI: 10.1039/D1RE00467K

Multilayered film microreactors fabricated by a one-step thermal bonding technique with high reproducibility and their applications

Kyoung-Ik Min, Jin-Oh Kim, Heejin Kim, Do Jin Im and Dong-Pyo Kim

Lab Chip, 2016, 16, 977
DOI: 10.1039/C5LC01585E

A micro-flow rapid dual activation approach for urethane-protected α-amino acid N-carboxyanhydride synthesis

Ren Okabe, Naoto Sugisawa and Shinichiro Fuse

Org. Biomol. Chem., 2022, 20, 3303
DOI: 10.1039/D2OB00167E

Taming hazardous chemistry by continuous flow technology

M. Movsisyan, E. I. P. Delbeke, J. K. E. T. Berton, C. Battilocchio, S. V. Ley and C. V. Stevens

Chem. Soc. Rev., 2016, 45, 4892
DOI: 10.1039/C5CS00902B

Flash generation of α-(trifluoromethyl)vinyllithium and application to continuous flow three-component synthesis of α-trifluoromethylamides

Aiichiro Nagaki, Shinya Tokuoka and Jun-ichi Yoshida

Chem. Commun., 2014, 50, 15079
DOI: 10.1039/C4CC06709F

Flash carboxylation: fast lithiation–carboxylation sequence at room temperature in continuous flow

Bartholomäus Pieber, Toma Glasnov and C. O. Kappe

RSC Adv., 2014, 4, 13430
DOI: 10.1039/c4ra01442a

Multi-objective Bayesian optimisation using q-noisy expected hypervolume improvement (qNEHVI) for the Schotten–Baumann reaction

Jiyizhe Zhang, Naoto Sugisawa, Kobi C. Felton, Shinichiro Fuse and Alexei A. Lapkin

React. Chem. Eng., 2024, 9, 706
DOI: 10.1039/D3RE00502J

The in situ formation of nanoparticles via RAFT polymerization-induced self-assembly in a continuous tubular reactor

Jinying Peng, Chun Tian, Lifen Zhang, Zhenping Cheng and Xiulin Zhu

Polym. Chem., 2017, 8, 1495
DOI: 10.1039/C6PY02133F

Tools for chemical synthesis in microsystems

Klavs F. Jensen, Brandon J. Reizman and Stephen G. Newman

Lab Chip, 2014, 14, 3206
DOI: 10.1039/C4LC00330F

One-pot sequential 1,2-addition, Pd-catalysed cross-coupling of organolithium reagents with Weinreb amides

M. Giannerini, C. Vila, V. Hornillos and B. L. Feringa

Chem. Commun., 2016, 52, 1206
DOI: 10.1039/C5CC08507A

The scale-up of continuous biphasic liquid/liquid reactions under super-heating conditions: methodology and reactor design

Francesca Mandrelli, Alessia Buco, Lorenzo Piccioni, Florian Renner, Bertrand Guelat, Benjamin Martin, Berthold Schenkel and Francesco Venturoni

Green Chem., 2017, 19, 1425
DOI: 10.1039/C6GC02840C

Flow trifluoromethylation of carbonyl compounds by Ruppert–Prakash reagent and its application for pharmaceuticals, efavirenz and HSD-016

Satoshi Okusu, Kazuki Hirano, Yoshimasa Yasuda, Etsuko Tokunaga and Norio Shibata

RSC Adv., 2016, 6, 82716
DOI: 10.1039/C6RA19790F

Improving photo-controlled living radical polymerization from trithiocarbonates through the use of continuous-flow techniques

Mao Chen and Jeremiah A. Johnson

Chem. Commun., 2015, 51, 6742
DOI: 10.1039/C5CC01562F

High-performance monoliths in heterogeneous catalysis with single-phase liquid flow

Christian P. Haas, Tibor Müllner, Richard Kohns, Dirk Enke and Ulrich Tallarek

React. Chem. Eng., 2017, 2, 498
DOI: 10.1039/C7RE00042A

Selective monomethylation of primary amines with simple electrophiles

Thomas Lebleu, Xiaolu Ma, Jacques Maddaluno and Julien Legros

Chem. Commun., 2014, 50, 1836
DOI: 10.1039/c3cc48997c

Rapid in situ generation of 2-(halomethyl)-5-phenylfuran and nucleophilic addition in a microflow reactor

Yuma Matsuura and Shinichiro Fuse

Org. Biomol. Chem., 2024, 22, 3448
DOI: 10.1039/D4OB00358F

Oxidation of cinnamyl alcohol using bimetallic Au–Pd/TiO2 catalysts: a deactivation study in a continuous flow packed bed microreactor

Gaowei Wu, Gemma L. Brett, Enhong Cao, Achilleas Constantinou, Peter Ellis, Simon Kuhn, Graham J. Hutchings, Donald Bethell and Asterios Gavriilidis

Catal. Sci. Technol., 2016, 6, 4749
DOI: 10.1039/C6CY00232C

Continuous flow synthesis of pyridinium salts accelerated by multi-objective Bayesian optimization with active learning

John H. Dunlap, Jeffrey G. Ethier, Amelia A. Putnam-Neeb, Sanjay Iyer, Shao-Xiong Lennon Luo, Haosheng Feng, Jose Antonio Garrido Torres, Abigail G. Doyle, Timothy M. Swager, Richard A. Vaia, Peter Mirau, Christopher A. Crouse and Luke A. Baldwin

Chem. Sci., 2023, 14, 8061
DOI: 10.1039/D3SC01303K

Mechanism-guided design of flow systems for multicomponent reactions: conversion of CO2 and olefins to cyclic carbonates

Jie Wu, Jennifer A. Kozak, Fritz Simeon, T. Alan Hatton and Timothy F. Jamison

Chem. Sci., 2014, 5, 1227
DOI: 10.1039/c3sc53422g

A pressure-tolerant polymer microfluidic device fabricated by the simultaneous solidification-bonding method and flash chemistry application

Wurong Ren, Heejin Kim, Hyune-Jea Lee, Jun Wang, Hao Wang and Dong-Pyo Kim

Lab Chip, 2014, 14, 4263
DOI: 10.1039/C4LC00560K

An anodic aromatic C,C cross-coupling reaction using parallel laminar flow mode in a flow microreactor

Toshihiro Arai, Hiroyuki Tateno, Koji Nakabayashi, Tsuneo Kashiwagi and Mahito Atobe

Chem. Commun., 2015, 51, 4891
DOI: 10.1039/C5CC01253H

Practical preparation of challenging amides from non-nucleophilic amines and esters under flow conditions

Johannes L. Vrijdag, Francisca Delgado, Nerea Alonso, Wim M. De Borggraeve, Natalia Pérez-Macias and Jesus Alcázar

Chem. Commun., 2014, 50, 15094
DOI: 10.1039/C4CC07129H

Continuous-flow azide–alkyne cycloadditions with an effective bimetallic catalyst and a simple scavenger system

Sándor B. Ötvös, Gábor Hatoss, Ádám Georgiádes, Szabolcs Kovács, István M. Mándity, Zoltán Novák and Ferenc Fülöp

RSC Adv., 2014, 4, 46666
DOI: 10.1039/C4RA07954J

Continuous flow chemistry: a discovery tool for new chemical reactivity patterns

Jan Hartwig, Jan B. Metternich, Nikzad Nikbin, Andreas Kirschning and Steven V. Ley

Org. Biomol. Chem., 2014, 12, 3611
DOI: 10.1039/C4OB00662C

The “factory in a lab”: telescoping the Matteson and Matteson–Hoppe–Aggarwal boronate chemistry under flow conditions

Florian Fricke, Gerald Dräger and Andreas Kirschning

React. Chem. Eng., 2025, 10, 1048
DOI: 10.1039/D4RE00394B

Integrating continuous flow synthesis with in-line analysis and data generation

Marcus Baumann

Org. Biomol. Chem., 2018, 16, 5946
DOI: 10.1039/C8OB01437J

Enone-promoted decarboxylation of trans-4-hydroxy-l-proline in flow: a side-by-side comparison to batch

Rowan L. Pilkington, Madeleine A. Dallaston, G. Paul Savage, Craig M. Williams and Anastasios Polyzos

React. Chem. Eng., 2021, 6, 486
DOI: 10.1039/D0RE00442A

Ruthenium polypyridyl complex-catalysed aryl alkoxylation of styrenes: improving reactivity using a continuous flow photo-microreactor

Eiji Yamaguchi, Nao Taguchi and Akichika Itoh

React. Chem. Eng., 2019, 4, 995
DOI: 10.1039/C9RE00061E

Continuous one-flow multi-step synthesis of active pharmaceutical ingredients

Victor R. L. J. Bloemendal, Mathilde A. C. H. Janssen, Jan C. M. van Hest and Floris P. J. T. Rutjes

React. Chem. Eng., 2020, 5, 1186
DOI: 10.1039/D0RE00087F

Control of tandem isomerizations: flow-assisted reactions ofo-lithiated aryl benzyl ethers

Hyune-Jea Lee, Heejin Kim, Jun-ichi Yoshida and Dong-Pyo Kim

Chem. Commun., 2018, 54, 547
DOI: 10.1039/C7CC08460A

Continuous synthesis of artemisinin-derived medicines

Kerry Gilmore, Daniel Kopetzki, Ju Weon Lee, Zoltán Horváth, D. Tyler McQuade, Andreas Seidel-Morgenstern and Peter H. Seeberger

Chem. Commun., 2014, 50, 12652
DOI: 10.1039/C4CC05098C

Flow chemistry as a versatile tool for the synthesis of triazoles

Sándor B. Ötvös and Ferenc Fülöp

Catal. Sci. Technol., 2015, 5, 4926
DOI: 10.1039/C5CY00523J

Counting bubbles: precision process control of gas–liquid reactions in flow with an optical inline sensor

Nikolay Cherkasov, Antonio José Expósito, Yang Bai and Evgeny V. Rebrov

React. Chem. Eng., 2019, 4, 112
DOI: 10.1039/C8RE00186C

Examining the interfacial behavior of non-Newtonian gas-liquid two-phase flow in horizontal square microchannels

Haslinda Kusumaningsih, Indarto, Akimaro Kawahara, I.G.N.B. Catrawedarma and Deendarlianto

Flow Measurement and Instrumentation, 2024, 96, 102548
DOI: 10.1016/j.flowmeasinst.2024.102548

Flash Electrochemical Approach to Carbocations

Masahiro Takumi, Hodaka Sakaue and Aiichiro Nagaki

Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202116177

In vitro, in vivo and in silico antiplasmodial profiling of the aqueous extract of Hibiscus asper HOOK F. Leaf (Malvaceae)

Marius Jaurès Tsakem Nangap, Lucain Walbadet, Michel Arnaud Mbock, Abel Idrice Adjieufack, Jean Moto Ongagna, Roberto Fokou, Loïc Ngwem Tenlep, Mariscal Brice Tchatat, Patrick Valère Tsouh Fokou, Fabrice Fekam Boyom, Raceline Gounoue kamkumo, Florence Ngueguim Tsofack and Théophile Dimo

Journal of Ethnopharmacology, 2024, 335, 118536
DOI: 10.1016/j.jep.2024.118536

Model-Based Scale-Up Predictions: From Micro- to Millireactors Using Inline Fourier Transform Infrared Spectroscopy

Verena Fath, Stefanie Szmais, Philipp Lau, Norbert Kockmann and Thorsten Röder

Org. Process Res. Dev., 2019, 23, 2020
DOI: 10.1021/acs.oprd.9b00265

Fixation of carbon dioxide to aryl/aromatic carboxylic acids

Ashutosh Rawat, Sonu Dhakla, Prem Lama and Tapan K. Pal

Journal of CO2 Utilization, 2022, 59, 101939
DOI: 10.1016/j.jcou.2022.101939

Organocatalyzed Beckmann rearrangement of cyclohexanone oxime in a microreactor: Kinetic model and product inhibition

Chencan Du, Jisong Zhang and Guangsheng Luo

AIChE Journal, 2018, 64, 571
DOI: 10.1002/aic.15946

Flow Asymmetric Propargylation: Development of Continuous Processes for the Preparation of a Chiral β‐Amino Alcohol

Hui Li, Jillian W. Sheeran, Andrew M. Clausen, Yuan‐Qing Fang, Matthew M. Bio and Scott Bader

Angewandte Chemie, 2017, 129, 9553
DOI: 10.1002/ange.201704882

Design, Fundamental Principles of Fabrication and Applications of Microreactors

Adama A. Bojang and Ho-Shing Wu

Processes, 2020, 8, 891
DOI: 10.3390/pr8080891

Rapid-Flow Synthesis of Zn-Qn Complexes: Teaching Old Ligands New Tricks with Reactive Na2(HZnEt2)2

Levi Zane Miller, Jeremy J. Hrudka, Yuta R. Naro, Michael Haaf, Michael Shatruk and D. Tyler McQuade

J Flow Chem, 2015, 5, 139
DOI: 10.1556/JFC-D-14-00039

Micro-Flow N-Acylation Using Highly Electrophilic Acyl Ammonium Cations for Peptide and Urethane-Protected N-Carboxyanhydride Syntheses

Hisashi Masui and Shinichiro Fuse

J. Synth. Org. Chem. Jpn., 2022, 80, 986
DOI: 10.5059/yukigoseikyokaishi.80.986

Selective Continuous Flow Iodination Guided by Direct Spectroscopic Observation of Equilibrating Aryl Lithium Regioisomers

Anna L. Dunn, David C. Leitch, Michel Journet, Michael Martin, Elie A. Tabet, Neil R. Curtis, Glynn Williams, Charles Goss, Tony Shaw, Bernie O’Hare, Charles Wade, Matthew A. Toczko and Peng Liu

Organometallics, 2019, 38, 129
DOI: 10.1021/acs.organomet.8b00538

Chemical Assembly Systems: Layered Control for Divergent, Continuous, Multistep Syntheses of Active Pharmaceutical Ingredients

Diego Ghislieri, Kerry Gilmore and Peter H. Seeberger

Angew Chem Int Ed, 2015, 54, 678
DOI: 10.1002/anie.201409765

Regioselective Synthesis of α-Functional Stilbenes via Precise Control of Rapid cis–trans Isomerization in Flow

Hyune-Jea Lee, Yuya Yonekura, Nayoung Kim, Jun-ichi Yoshida and Heejin Kim

Org. Lett., 2021, 23, 2904
DOI: 10.1021/acs.orglett.1c00538

Intensification of diethyl methylphosphite synthesis based on kinetics study and CFD modeling

Banghao Li, Xiaocheng Lan and Tiefeng Wang

AIChE Journal, 2024, 70
DOI: 10.1002/aic.18264

3D‐Continuous Nanoporous Covalent Framework Membrane Nanoreactors with Quantitatively Loaded Ultrafine Pd Nanocatalysts

Dawoon Jeong, Wangsuk Oh and Ji‐Woong Park

Small, 2024, 20
DOI: 10.1002/smll.202309490

Flow Chemistry in Contemporary Chemical Sciences: A Real Variety of Its Applications

Marek Trojanowicz

Molecules, 2020, 25, 1434
DOI: 10.3390/molecules25061434

Integrated One‐Flow Synthesis of Heterocyclic Thioquinazolinones through Serial Microreactions with Two Organolithium Intermediates

Heejin Kim, Hyune‐Jea Lee and Dong‐Pyo Kim

Angew Chem Int Ed, 2015, 54, 1877
DOI: 10.1002/anie.201410062

Recent Advances in Continuous-Flow Reactions Using Metal-Free Homogeneous Catalysts

Naoto Sugisawa, Hiroyuki Nakamura and Shinichiro Fuse

Catalysts, 2020, 10, 1321
DOI: 10.3390/catal10111321

Protected Diazonium Salts: A Continuous-Flow Preparation of Triazenes Including the Anticancer Compounds Dacarbazine and Mitozolomide

Christiane Schotten, Abdul Hadi Aldmairi, Yerbol Sagatov, Martyn Shepherd and Duncan L. Browne

J Flow Chem, 2016, 6, 218
DOI: 10.1556/1846.2016.00025

Generation and Reaction of Functional Alkyllithiums by Using Microreactors and Their Application to Heterotelechelic Polymer Synthesis

Aiichiro Nagaki, Hiroki Yamashita, Yuta Tsuchihashi, Katsuyuki Hirose, Masahiro Takumi and Jun‐ichi Yoshida

Chemistry A European J, 2019, 25, 13719
DOI: 10.1002/chem.201902867

Incorporative Mixing in Microreactors: Influence on Reactions and Importance of Inlet Designation

Shusaku Asano, Taisuke Maki, Shogo Inoue, Sumito Sogo, Masashi Furuta, Satoshi Watanabe, Yosuke Muranaka, Shinji Kudo, Jun-ichiro Hayashi and Kazuhiro Mae

SSRN Journal, 2022
DOI: 10.2139/ssrn.4140954

Organocatalyzed continuous flow ring-opening polymerizations to homo- and block-polylactones

Ning Zhu, Weiyang Feng, Xin Hu, Zilong Zhang, Zheng Fang, Kai Zhang, Zhenjiang Li and Kai Guo

Polymer, 2016, 84, 391
DOI: 10.1016/j.polymer.2016.01.019

Recent Progress in Electrochemical Fixation of CO2 to Construct Carboxylic Acid Derivatives

Yongzhou Pan, Xiujin Meng, Yingchun Wang and Muxue He

Chinese Journal of Organic Chemistry, 2023, 43, 1416
DOI: 10.6023/cjoc202208004

Protective Filtration for Microfluidic Nanoparticle Precipitation for Pharmaceutical Applications

Holger Bolze, Juliane Riewe, Heike Bunjes, Andreas Dietzel and Thomas P. Burg

Chem Eng & Technol, 2021, 44, 457
DOI: 10.1002/ceat.202000475

Experimental and numerical investigation of the reaction of 2,4‐thiazolidinedione and p‐methoxybenzaldehyde in microreactors for the production of drugs for diabetes mellitus type 2 treatment

Rodrigo de Oliveira Vieira, João Lameu Silva, Paula Almeida Meira, Gabriel Lima Bressan, Paulo Victor Cuesta Calvo, Harrson Silva Santana and Mauri S. A. Palma

Can J Chem Eng, 2023, 101, 6505
DOI: 10.1002/cjce.24934

Sustainable Continuous Synthesis of 3,5-Disubstituted Isoxazoles: Development of an Integrated Reaction–Separation–Recovery System for Deep Eutectic Solvents

Gwang-Noh Ahn, Jung-Ah Shin and Sejin Lee

ACS Sustainable Chem. Eng., 2025, 13, 6589
DOI: 10.1021/acssuschemeng.5c00580

Flash Organometallic Catalysis Uncovered by Continuous Microfluidic Devices

Fanfu Guan and Jialin Wen

ChemPlusChem, 2024, 89
DOI: 10.1002/cplu.202300646

Continuous‐Flow N‐Heterocyclic Carbene Generation and Organocatalysis

Lorenzo Di Marco, Morgan Hans, Lionel Delaude and Jean‐Christophe M. Monbaliu

Chemistry A European J, 2016, 22, 4508
DOI: 10.1002/chem.201505135

Extremely Fast Gas/Liquid Reactions in Flow Microreactors: Carboxylation of Short‐Lived Organolithiums

Aiichiro Nagaki, Yusuke Takahashi and Jun‐ichi Yoshida

Chemistry A European J, 2014, 20, 7931
DOI: 10.1002/chem.201402520

Reducing pH Gradients in Free-Flow Electrophoresis

Fletcher J. Agostino, Leonid T. Cherney, Mirzo Kanoatov and Sergey N. Krylov

Anal. Chem., 2014, 86, 5656
DOI: 10.1021/ac501081b

Selective Oxidation of Activated Alcohols by Supported Gold Nanoparticles under an Atmospheric Pressure of O2: Batch and Continuous‐Flow Studies

Pascal D. Giorgi, Nelli Elizarov and Sylvain Antoniotti

ChemCatChem, 2017, 9, 1830
DOI: 10.1002/cctc.201700179

Development of a Robust and Reusable Microreactor Employing Laser Based Mid-IR Chemical Imaging for the Automated Quantification of Reaction Kinetics

Hakan Keles, Flavien Susanne, Hamish Livingstone, Sarah Hunter, Charles Wade, Rose Bourdon and Andrew Rutter

Org. Process Res. Dev., 2017, 21, 1761
DOI: 10.1021/acs.oprd.7b00245

“Impossible” Chemistries Based on Flow and Micro

Jun-ichi Yoshida, Heejin Kim and Aiichiro Nagaki

J Flow Chem, 2017, 7, 60
DOI: 10.1556/1846.2017.00017

Recent advances exploiting reactive intermediates generated via continuous flow chemistry

Arlene Bonner, Parth Naik, Ruairi Crawford and Marcus Baumann

Current Opinion in Green and Sustainable Chemistry, 2024, 47, 100907
DOI: 10.1016/j.cogsc.2024.100907

Metal‐organic framework derived porous structures towards lithium rechargeable batteries

Sang A Han, Hamzeh Qutaish, Jong‐Won Lee, Min‐Sik Park and Jung Ho Kim

EcoMat, 2023, 5
DOI: 10.1002/eom2.12283

Direct Synthesis of Hydroquinones from Quinones through Sequential and Continuous‐Flow Hydrogenation‐Derivatization Using Heterogeneous Au–Pt Nanoparticles as Catalysts

Hiroyuki Miyamura, Fumiya Tobita, Aya Suzuki and Shū Kobayashi

Angew Chem Int Ed, 2019, 58, 9220
DOI: 10.1002/anie.201904159

Continuous‐Flow Synthesis of Biaryls by Negishi Cross‐Coupling of Fluoro‐ and Trifluoromethyl‐Substituted (Hetero)arenes

Stefan Roesner and Stephen L. Buchwald

Angew Chem Int Ed, 2016, 55, 10463
DOI: 10.1002/anie.201605584

Process control with compact NMR

Klas Meyer, Simon Kern, Nicolai Zientek, Gisela Guthausen and Michael Maiwald

TrAC Trends in Analytical Chemistry, 2016, 83, 39
DOI: 10.1016/j.trac.2016.03.016

Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides: Mechanistic Investigation and Application to a Microwave Flow Process

Megumi Noshita, Yuhei Shimizu, Hiroyuki Morimoto, Shuji Akai, Yoshitaka Hamashima, Noriyuki Ohneda, Hiromichi Odajima and Takashi Ohshima

Org. Process Res. Dev., 2019, 23, 588
DOI: 10.1021/acs.oprd.8b00424

From p‐Xylene to Ibuprofen in Flow: Three‐Step Synthesis by a Unified Sequence of Chemoselective C−H Metalations

Hyune‐Jea Lee, Heejin Kim and Dong‐Pyo Kim

Chemistry A European J, 2019, 25, 11641
DOI: 10.1002/chem.201903267

Exploring New Parameter Spaces for the Oxidative Homocoupling of Aniline Derivatives: Sustainable Synthesis of Azobenzenes in a Flow System

Ádám Georgiádes, Sándor B. Ötvös and Ferenc Fülöp

ACS Sustainable Chem. Eng., 2015, 3, 3388
DOI: 10.1021/acssuschemeng.5b01096

Enzymatic Continuous Flow Synthesis of Thiol‐Terminated Poly(δ‐Valerolactone) and Block Copolymers

Ning Zhu, Weijun Huang, Xin Hu, Yihuan Liu, Zheng Fang and Kai Guo

Macromol. Rapid Commun., 2018, 39
DOI: 10.1002/marc.201700807

Continuous flow reaction system for the synthesis of 2,2,2-trichloroacetophenone derivatives and its application

Byeng Ha Ko, Subeen Yu, Kwang Ho Song and Sunwoo Lee

Tetrahedron Letters, 2018, 59, 991
DOI: 10.1016/j.tetlet.2018.01.067

Synthesis of Bisdesmosidic Oleanolic Acid Saponins via a Glycosylation-Deprotection Sequence under Continuous Microfluidic/Batch Conditions

Naruki Konishi, Tatsuya Shirahata, Masaki Yokoyama, Tatsuya Katsumi, Yoshikazu Ito, Nozomu Hirata, Takashi Nishino, Kazuishi Makino, Noriko Sato, Takayuki Nagai, Hiroaki Kiyohara, Haruki Yamada, Eisuke Kaji and Yoshinori Kobayashi

J. Org. Chem., 2017, 82, 6703
DOI: 10.1021/acs.joc.7b00841

Self-Assembled Asymmetric Catalyst Engaged in a Continuous-Flow Platform: AnAnti-Selective Catalytic Asymmetric Nitroaldol Reaction

Kazuki Hashimoto, Naoya Kumagai and Masakatsu Shibasaki

Org. Lett., 2014, 16, 3496
DOI: 10.1021/ol501432h

Selective Monoprotection of Symmetrical Diols in a Flow Reactor

Hisashi Masui, Masaru Takizawa, Yuki Sakai, Yasuhiro Kajiwara, Kiyofumi Wanibuchi, Mitsuru Shoji and Takashi Takahashi

IJOC, 2018, 08, 264
DOI: 10.4236/ijoc.2018.82019

A Carbon Nanotube Confinement Strategy to Implement Homogeneous Asymmetric Catalysis in the Solid Phase

Kazuki Hashimoto, Naoya Kumagai and Masakatsu Shibasaki

Chemistry A European J, 2015, 21, 4262
DOI: 10.1002/chem.201406402

Reactions of Difunctional Electrophiles with Functionalized Aryllithium Compounds: Remarkable Chemoselectivity by Flash Chemistry

Aiichiro Nagaki, Keita Imai, Satoshi Ishiuchi and Jun‐ichi Yoshida

Angewandte Chemie, 2015, 127, 1934
DOI: 10.1002/ange.201410717

Time Economy in Total Synthesis

Yujiro Hayashi

J. Org. Chem., 2021, 86, 1
DOI: 10.1021/acs.joc.0c01581

Rapid and Mild One‐Flow Synthetic Approach to Unsymmetrical Sulfamides Guided by Bayesian Optimization

Naoto Sugisawa, Hiroki Sugisawa, Yuma Otake, Roman V. Krems, Hiroyuki Nakamura and Shinichiro Fuse

Chemistry Methods, 2021, 1, 484
DOI: 10.1002/cmtd.202100053

Selective Decarboxylative Fluorination of β‐Keto Acids in Aqueous Media: 19F‐NMR‐Assisted Batch Optimization and Transfer to Continuous Flow

Egzon Cermjani, Christoph Deckers, Michael Maskos and Thomas H. Rehm

Chemistry A European J, 2025, 31
DOI: 10.1002/chem.202404435

Formal Halogen Transfer of Bromoarenes via Stepwise Reactions

Kengo Inoue, Atsunori Mori and Kentaro Okano

Org. Lett., 2023, 25, 6693
DOI: 10.1021/acs.orglett.3c02540

Flow‐based SPPS for protein synthesis: A perspective

Zachary P. Gates and Nina Hartrampf

Peptide Science, 2020, 112
DOI: 10.1002/pep2.24198

Organocatalyzed Beckmann Rearrangement of Cyclohexanone Oxime in a Microchemical System

Jisong Zhang, Chen Dong, Chencan Du and Guangsheng Luo

Org. Process Res. Dev., 2015, 19, 352
DOI: 10.1021/op500370u

In situ fabric coloration with indigo synthesised in flow

Michael P. Haaf, Katrina M. Piemonte, D. Tyler McQuade, Lucy Cotton and Richard S. Blackburn

Coloration Technology, 2019, 135, 127
DOI: 10.1111/cote.12383

Numerical and Experimental Quantification of the Performance of Microreactors for Scaling-up Fast Chemical Reactions

Shusaku Asano, Shota Yatabe, Taisuke Maki and Kazuhiro Mae

Org. Process Res. Dev., 2019, 23, 807
DOI: 10.1021/acs.oprd.8b00356

The Hitchhiker’s Guide to Flow Chemistry

Matthew B. Plutschack, Bartholomäus Pieber, Kerry Gilmore and Peter H. Seeberger

Chem. Rev., 2017, 117, 11796
DOI: 10.1021/acs.chemrev.7b00183

Hydrodynamics and quality of micromixing in microreactors: Comparison of intensively swirled flows and submerged impinging jets

R․ Sh․ Abiev and I.V. Makusheva

Chemical Engineering and Processing - Process Intensification, 2025, 216, 110452
DOI: 10.1016/j.cep.2025.110452

One‐Flow Synthesis of Substituted Indoles via Sequential 1,2‐Addition/Nucleophilic Substitution of Indolyl‐3‐Carbaldehydes

Shinichiro Fuse, Sena Kanda and Hisashi Masui

Chemistry An Asian Journal, 2024, 19
DOI: 10.1002/asia.202300909

Integrated Flow Processing — Challenges in Continuous Multistep Synthesis

Bartholomäus Pieber, Kerry Gilmore and Peter H. Seeberger

J Flow Chem, 2017, 7, 129
DOI: 10.1556/1846.2017.00016

Synthetic Chemistry in Flow Microreactors

Aiichiro Nagaki

J. Syn. Org. Chem., Jpn., 2015, 73, 423
DOI: 10.5059/yukigoseikyokaishi.73.423

Continuous Flow C-Glycosylation via Metal–Halogen Exchange: Process Understanding and Improvements toward Efficient Manufacturing of Remdesivir

Timo von Keutz, Jason D. Williams and C. Oliver Kappe

Org. Process Res. Dev., 2020, 24, 2362
DOI: 10.1021/acs.oprd.0c00370

Ex-situ generation and synthetic utilization of bare trifluoromethyl anion in flow via rapid biphasic mixing

Hyune-Jea Lee, Jeong-Un Joo, Se-Jun Yim, Dong-Pyo Kim and Heejin Kim

Nat Commun, 2023, 14
DOI: 10.1038/s41467-022-35611-9

Preparation of Nd/Na heterogeneous catalyst from bench-stable and inexpensive Nd salt for an anti-selective catalytic asymmetric nitroaldol reaction

Akihito Nonoyama, Kazuki Hashimoto, Akira Saito, Naoya Kumagai and Masakatsu Shibasaki

Tetrahedron Letters, 2016, 57, 1815
DOI: 10.1016/j.tetlet.2016.03.041

Convergent approach for direct cross-coupling enabled by flash irreversible generation of cationic and anionic species

Hiroki Soutome, Hiroki Yamashita, Yutaka Shimizu, Masahiro Takumi, Yosuke Ashikari and Aiichiro Nagaki

Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-48723-1

Recent Advances in the Solid- and Solution-Phase Synthesis of Peptides and Proteins Using Microflow Technology

Hisashi Masui and Shinichiro Fuse

Org. Process Res. Dev., 2022, 26, 1751
DOI: 10.1021/acs.oprd.2c00074

Continuous Flow Technology as an Enabler for Innovative Transformations Exploiting Carbenes, Nitrenes, and Benzynes

Kian Donnelly and Marcus Baumann

J. Org. Chem., 2022, 87, 8279
DOI: 10.1021/acs.joc.2c00963

Olefin Metathesis under Spatial Confinement and Continuous Flow: Investigation of Isomeric Side Reactions with a Grubbs–Hoveyda Type Catalyst

André Böth, Thomas Roider, Felix Ziegler, Xiulan Xie, Michael R. Buchmeiser and Ulrich Tallarek

ChemCatChem, 2023, 15
DOI: 10.1002/cctc.202201268

Flash Chemistry Using Trichlorovinyllithium: Switching the Reaction Pathways by High-resolution Reaction Time Control

Aiichiro Nagaki, Yusuke Takahashi, Andrea Henseler, Chika Matsuo and Jun-ichi Yoshida

Chemistry Letters, 2015, 44, 214
DOI: 10.1246/cl.140980

Fast Isomerization Before Isomerization‐Hydroformylation: Probing the Neglected Period with A Novel Microfluidic Device

Fanfu Guan, Yu Qian, Peiqi Zhang, Runtong Zhang, Xumu Zhang and Jialin Wen

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202302777

Process Intensification of Continuous-Flow Imine Hydrogenation in Catalyst-Coated Tube Reactors

Antonio J. Exposito, Yang Bai, Kirill Tchabanenko, Evgeny V. Rebrov and Nikolay Cherkasov

Ind. Eng. Chem. Res., 2019, 58, 4433
DOI: 10.1021/acs.iecr.8b06058

Chemoselective Flow Hydrogenation Approaches to Diversify the Cytotoxic Tetrahydroepoxyisoindole Carboxamide Scaffold

Lawson K. Spare, David G. Harman, Janice R. Aldrich‐Wright, Thanh V. Nguyen and Christopher P. Gordon

Adv Synth Catal, 2018, 360, 1209
DOI: 10.1002/adsc.201701471

Improved efficiency of continuous conversion of alcohols to chlorides in flow microreactors with DESs/HCl via predictive fluid model

Shu-Yi Huang, Yan Zhou, Yu-Xuan Huang, Nan Wang, Zi-Teng Gao, Ming-Shuai Sun, Wei Hui and Duan-Jian Tao

Journal of Molecular Liquids, 2024, 413, 126041
DOI: 10.1016/j.molliq.2024.126041

Synthetic Organic Chemistry Based on Control of Time by Space

Jun-ichi Yoshida

J. Syn. Org. Chem., Jpn., 2018, 76, 373
DOI: 10.5059/yukigoseikyokaishi.76.373

Current status and future prospects for enabling chemistry technology in the drug discovery process

Stevan W. Djuric, Charles W. Hutchins and Nari N. Talaty

F1000Res, 2016, 5, 2426
DOI: 10.12688/f1000research.9515.1

3D-Printed Labware for High-Throughput Immobilization of Enzymes

Michael B. Spano, Brandan H. Tran, Sudipta Majumdar and Gregory A. Weiss

J. Org. Chem., 2020, 85, 8480
DOI: 10.1021/acs.joc.0c00789

Trends and Challenges in Multistep Continuous Flow Synthesis

Junjie Chen, Yibo Zou, Lianan Liao, Baochao Yang, Dong Xing, Jian Zhou, Xuhong Qian, Yingzhe Liu, Haibing He and Shuanhu Gao

JACS Au, 2026, 6, 731
DOI: 10.1021/jacsau.5c01611

A Modular Programmable Inorganic Cluster Discovery Robot for the Discovery and Synthesis of Polyoxometalates

Daniel S. Salley, Graham A. Keenan, De-Liang Long, Nicola L. Bell and Leroy Cronin

ACS Cent. Sci., 2020, 6, 1587
DOI: 10.1021/acscentsci.0c00415

Eine kurze Durchflusssynthese von Efavirenz

Camille A. Correia, Kerry Gilmore, D. Tyler McQuade and Peter H. Seeberger

Angewandte Chemie, 2015, 127, 5028
DOI: 10.1002/ange.201411728

External Trapping of Halomethyllithium Enabled by Flow Microreactors

Leonardo Degennaro, Flavio Fanelli, Arianna Giovine and Renzo Luisi

Adv Synth Catal, 2015, 357, 21
DOI: 10.1002/adsc.201400747

Polymer Synthesis in Continuous Flow Reactors

Neomy Zaquen, Maarten Rubens, Nathaniel Corrigan, Jiangtao Xu, Per B. Zetterlund, Cyrille Boyer and Tanja Junkers

Progress in Polymer Science, 2020, 107, 101256
DOI: 10.1016/j.progpolymsci.2020.101256

Incorporative mixing in microreactors: Influence on reactions and importance of inlet designation

Shusaku Asano, Taisuke Maki, Shogo Inoue, Sumito Sogo, Masashi Furuta, Satoshi Watanabe, Yosuke Muranaka, Shinji Kudo, Jun-ichiro Hayashi and Kazuhiro Mae

Chemical Engineering Journal, 2023, 451, 138942
DOI: 10.1016/j.cej.2022.138942

Continuous‐Flow Synthesis of Biaryls by Negishi Cross‐Coupling of Fluoro‐ and Trifluoromethyl‐Substituted (Hetero)arenes

Stefan Roesner and Stephen L. Buchwald

Angewandte Chemie, 2016, 128, 10619
DOI: 10.1002/ange.201605584

Flow “Fine” Synthesis: High Yielding and Selective Organic Synthesis by Flow Methods

Shū Kobayashi

Chemistry An Asian Journal, 2016, 11, 425
DOI: 10.1002/asia.201500916

Design and Application of a Low-Temperature Continuous Flow Chemistry Platform

James A. Newby, D. Wayne Blaylock, Paul M. Witt, Julio C. Pastre, Marija K. Zacharova, Steven V. Ley and Duncan L. Browne

Org. Process Res. Dev., 2014, 18, 1211
DOI: 10.1021/op500213j

Continuous Flow Synthesis of Terminal Epoxides from Ketones Using in Situ Generated Bromomethyl Lithium

Timo von Keutz, David Cantillo and C. Oliver Kappe

Org. Lett., 2019, 21, 10094
DOI: 10.1021/acs.orglett.9b04072

Opportunities and Challenges in the Synthesis of Noble Metal Nanoparticles via the Chemical Route in Microreactor Systems

Adrianna Pach, Aleksandra Szot, Krzysztof Fitzner and Magdalena Luty-Błocho

Micromachines, 2024, 15, 1119
DOI: 10.3390/mi15091119

Pd nanoparticles decorated N-doped holey graphene assembled on aluminum silicate fibers agglomerate for catalytic continuous-flow reduction of nitroarenes

Jiahan Zhao, Anqi Zhang, Yingshuang Li, Hanyu Hu and Jiangbo Xi

Chemical Engineering Science, 2024, 286, 119656
DOI: 10.1016/j.ces.2023.119656

Synthesis of Functional Nanoparticles Using a Microreactor

Satoshi Watanabe and Minoru T. Miyahara

KONA, 2025, 42, 156
DOI: 10.14356/kona.2025003

Oscillatory flow reactor facilitates fast photochemical Wolff rearrangement toward synthesis of α-substituted amides in flow

Huashan Huang, Jingze Chen, Luyun Zhang, Hong Yan, Siqi Li and Fen-Er Chen

Chinese Chemical Letters, 2025, 36, 109992
DOI: 10.1016/j.cclet.2024.109992

Metallorganic reactions in the polytropic microreactors

Min Fu and Leslaw Mleczko

J Flow Chem, 2019, 9, 89
DOI: 10.1007/s41981-019-00030-3

Flow Microreactor Synthesis of Fluorine-Containing Block Copolymers

Aiichiro Nagaki, Kana Akahori, Yusuke Takahashi and Jun-ichi Yoshida

J Flow Chem, 2014, 4, 168
DOI: 10.1556/JFC-D-14-00017

Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor

Balázs Decsi, Réka Krammer, Kristóf Hegedűs, Ferenc Ender, Benjámin Gyarmati, András Szilágyi, Róbert Tőtős, Gabriel Katona, Csaba Paizs, György T. Balogh, László Poppe and Diána Balogh-Weiser

Micromachines, 2019, 10, 668
DOI: 10.3390/mi10100668

Memory of chirality in a room temperature flow electrochemical reactor

Tomas Hardwick, Rossana Cicala, Thomas Wirth and Nisar Ahmed

Sci Rep, 2020, 10
DOI: 10.1038/s41598-020-73957-6

Effect of Brønsted Acids on the Activation of Mixed Anhydride/Mixed Carbonic Anhydride and C‐Terminal‐Free N‐Methylated Peptide Synthesis in a Micro‐Flow Reactor

Ting‐Ho Chen, Akira Ando, Otoka Shamoto and Shinichiro Fuse

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202401402

A Unified Reactor Network Synthesis Framework for Simultaneous Consideration of Batch and Continuous-Flow Reactor Alternatives

Joseph G. Costandy, Thomas F. Edgar and Michael Baldea

Ind. Eng. Chem. Res., 2021, 60, 7232
DOI: 10.1021/acs.iecr.0c05799

Quantitative Perspective on Online Flow Reaction Profiling Using a Miniature Mass Spectrometer

Huaming Sheng, Emily B. Corcoran, Zachary E. X. Dance, Joseph P. Smith, Zhihao Lin, Victoria Ordsmith, Simon Hamilton and Ping Zhuang

Org. Process Res. Dev., 2020, 24, 2611
DOI: 10.1021/acs.oprd.0c00294

Pd clusters anchored on defect‐rich graphene enable efficient catalytic reduction of organic dyes in flow

Zhuo‐Yuan Bi, Shuo Li, Jian‐Hong Dai, Lei Yang, Pei Liu, Jiang‐Bo Xi and Xiang Peng

Rare Metals, 2025, 44, 4679
DOI: 10.1007/s12598-024-03222-6

Production scheduling for the reconfigurable modular pharmaceutical manufacturing processes

Congqin Ge and Zhihong Yuan

Computers & Chemical Engineering, 2021, 151, 107346
DOI: 10.1016/j.compchemeng.2021.107346

Safe Hydroformylation of Aliphatic Alkene in a Flow Reactor

Hisashi Masui, Eiki Honda, Sakura Niitsu, Mitsuru Shoji and Takashi Takahashi

IJOC, 2018, 08, 135
DOI: 10.4236/ijoc.2018.81009

Sequential Nucleophilic Substitution of Phosphorus Trichloride with Alcohols in a Continuous‐Flow Reactor and Consideration of a Mechanism for Reduced Over‐reaction through the Addition of Imidazole

Hiroshi Kitamura, Yuma Otake, Naoto Sugisawa, Hiroki Sugisawa, Tomonori Ida, Hiroyuki Nakamura and Shinichiro Fuse

Chemistry A European J, 2022, 28
DOI: 10.1002/chem.202200932

Flash cationic polymerization followed by bis-end-functionalization. A new approach to linear-dendritic hybrid polymers

Yosuke Tani, Masahiro Takumi, Satori Moronaga, Aiichiro Nagaki and Jun-ichi Yoshida

European Polymer Journal, 2016, 80, 227
DOI: 10.1016/j.eurpolymj.2016.02.021

The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

Marcus Baumann and Ian R Baxendale

Beilstein J. Org. Chem., 2015, 11, 1194
DOI: 10.3762/bjoc.11.134

Dichloromethyllithium: Synthesis and Application in Continuous Flow Mode

Andreas Hafner, Valentina Mancino, Mark Meisenbach, Berthold Schenkel and Joerg Sedelmeier

Org. Lett., 2017, 19, 786
DOI: 10.1021/acs.orglett.6b03753

Macroporous Gel with a Permeable Reaction Platform for Catalytic Flow Synthesis

Hikaru Matsumoto, Hirokazu Seto, Takanori Akiyoshi, Makoto Shibuya, Yu Hoshino and Yoshiko Miura

ACS Omega, 2017, 2, 8796
DOI: 10.1021/acsomega.7b00909

Advances in steady-state continuous-flow purification by small-scale free-flow electrophoresis

Fletcher J. Agostino and Sergey N. Krylov

TrAC Trends in Analytical Chemistry, 2015, 72, 68
DOI: 10.1016/j.trac.2015.03.023

Ultrafast Flow Synthesis of o-Functionalized Benzenesulfonyl Fluorides and Subsequent SuFEx Connections via Lithiated Chemistry

Ji-Ho Kang and Dong-Pyo Kim

Org. Lett., 2024, 26, 4824
DOI: 10.1021/acs.orglett.4c01700

Verification of preparations of (1H-indol-3-yl)methyl electrophiles and development of their microflow rapid generation and substitution

Hisashi Masui, Sena Kanda and Shinichiro Fuse

Commun Chem, 2023, 6
DOI: 10.1038/s42004-023-00837-1

Flow Technology for Telescoped Generation, Lithiation and Electrophilic (C3) Functionalization of Highly Strained 1‐Azabicyclo[1.1.0]butanes

Pantaleo Musci, Timo von Keutz, Ferdinand Belaj, Leonardo Degennaro, David Cantillo, C. Oliver Kappe and Renzo Luisi

Angew Chem Int Ed, 2021, 60, 6395
DOI: 10.1002/anie.202014881

Reductive Generation of Anionic C1 Carbenoid Species Attached to Organosulfur Functional Groups

Kazuhiro Okamoto, Shuto Wada, Kensuke Muta, Yuta Tsuchihashi and Aiichiro Nagaki

Chemistry An Asian Journal, 2026, 21
DOI: 10.1002/asia.70525

Opportunities for process intensification technologies in nuclear effluent treatment: A review of precipitators, adsorbers and separators

G. Yaghy, A.S. Tonge, H. Abouhakim, R. Peeling, M. Talford, L. O'Brien, A. Paksy, P. Nevitt, F.L. Muller, B.C. Hanson and T.N. Hunter

Chemical Engineering and Processing - Process Intensification, 2023, 191, 109441
DOI: 10.1016/j.cep.2023.109441

Flow‐Assisted Synthesis of [10]Cycloparaphenylene through Serial Microreactions under Mild Conditions

Heejin Kim, Hyune‐Jea Lee and Dong‐Pyo Kim

Angewandte Chemie, 2016, 128, 1444
DOI: 10.1002/ange.201509748

Innovative Carbonylation Methods

Takuji Kawamoto, Takahide Fukuyama and Ilhyong Ryu

J. Synth. Org. Chem. Jpn., 2014, 72, 493
DOI: 10.5059/yukigoseikyokaishi.72.493

Practical engineering aspects of catalysis in microreactors

J. Kristal, P. Stavarek, Z. Vajglova, M. Vondrackova, J. Pavlorkova and V. Jiricny

Res Chem Intermed, 2015, 41, 9357
DOI: 10.1007/s11164-015-2032-3

Intensification of Continuous Ortho-Lithiation at Ambient Conditions—Process Understanding and Assessment of Sustainability Benefits

Ruili Feng, Sushil Ramchandani, Balamurugan Ramalingam, Song Wei Benjamin Tan, Chuanzhao Li, Soo Khean Teoh, Kamelia Boodhoo and Paul Sharratt

Org. Process Res. Dev., 2017, 21, 1259
DOI: 10.1021/acs.oprd.7b00142

Flash Electrochemical Approach to Carbocations

Masahiro Takumi, Hodaka Sakaue and Aiichiro Nagaki

Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202116177

Flow chemistry—Microreaction technology comes of age

Klavs F. Jensen

AIChE Journal, 2017, 63, 858
DOI: 10.1002/aic.15642

Microflow, Sequential Coupling and Cyclization Approach for Synthesis of Cyclic Phosphotriesters from PCl3

Kohei Nakabayashi, Hiroshi Kitamura and Shinichiro Fuse

Chemistry An Asian Journal, 2024, 19
DOI: 10.1002/asia.202400256

A High Mobility Reactor Unit for R&D Continuous Flow Transfer Hydrogenations

Rasmus K. Jensen, Nikolaj Thykier, Martin V. Enevoldsen and Anders T. Lindhardt

Org. Process Res. Dev., 2017, 21, 370
DOI: 10.1021/acs.oprd.6b00441

Two‐step flow synthesis of Olaparib in microreactor: Route design, process development and kinetics research

Qilin Xu, Jun Chen, Zihao Wang, Yongjun Zang, Guosi Li, Fucheng Zhu, Dong Liu and Chaoyue Sun

Chemical Engineering Journal, 2023, 471, 144304
DOI: 10.1016/j.cej.2023.144304

Towards the Standardization of Flow Chemistry Protocols for Organic Reactions

Christopher A. Hone and C. Oliver Kappe

Chemistry Methods, 2021, 1, 454
DOI: 10.1002/cmtd.202100059

Continuous manufacturing as an enabling tool with green credentials in early-phase pharmaceutical chemistry

Benjamin Martin, Hansjoerg Lehmann, Hongwei Yang, Like Chen, Xiangguang Tian, Jutta Polenk and Berthold Schenkel

Current Opinion in Green and Sustainable Chemistry, 2018, 11, 27
DOI: 10.1016/j.cogsc.2018.03.005

Innovation of synthetic organic chemistry driven by automated flow synthesis and machine learning technology

Shinichiro Fuse

Jpn. J. Pestic. Sci., 2024, 49, 99
DOI: 10.1584/jpestics.W24-21

Flash Chemistry Approach to Organometallic C-Glycosylation for the Synthesis of Remdesivir

Timo von Keutz, Jason D. Williams and C. Oliver Kappe

Org. Process Res. Dev., 2021, 25, 1015
DOI: 10.1021/acs.oprd.1c00024

Polymer Immobilized Bimetallic Nanoparticle Catalysts for Selective Hydrogenation of Quinones and Integration of Quinone-hydrogenation and Its Derivatization Using Sequential and Continuous-flow Systems

Hiroyuki Miyamura, Fumiya Tobita, Aya Suzuki and Shū Kobayashi

J. Synth. Org. Chem. Jpn., 2020, 78, 232
DOI: 10.5059/yukigoseikyokaishi.78.232

A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow

Hongkun Lin, Chunhui Dai, Timothy F. Jamison and Klavs F. Jensen

Angewandte Chemie, 2017, 129, 8996
DOI: 10.1002/ange.201703812

Advancing Flow Chemistry Portability: A Simplified Approach to Scaling Up Flow Chemistry

François Lévesque, Nicholas J. Rogus, Glenn Spencer, Plamen Grigorov, Jonathan P. McMullen, David A. Thaisrivongs, Ian W. Davies and John R. Naber

Org. Process Res. Dev., 2018, 22, 1015
DOI: 10.1021/acs.oprd.8b00063

Rational design of the inlet configuration of flow systems for enhanced mixing

Yunhu Gao, Di Fu Zhu, Yuan Han and Laura Torrente-Murciano

J Flow Chem, 2021, 11, 589
DOI: 10.1007/s41981-021-00184-z

Maschinengestützte organische Synthese

Steven V. Ley, Daniel E. Fitzpatrick, Rebecca M. Myers, Claudio Battilocchio and Richard. J. Ingham

Angewandte Chemie, 2015, 127, 10260
DOI: 10.1002/ange.201501618

Green Chemistry in the Synthesis of Pharmaceuticals

Supratik Kar, Hans Sanderson, Kunal Roy, Emilio Benfenati and Jerzy Leszczynski

Chem. Rev., 2022, 122, 3637
DOI: 10.1021/acs.chemrev.1c00631

Continuous Flow Synthesis of Ketones from Carbon Dioxide and Organolithium or Grignard Reagents

Jie Wu, Xiaoqing Yang, Zhi He, Xianwen Mao, T. Alan Hatton and Timothy F. Jamison

Angew Chem Int Ed, 2014, 53, 8416
DOI: 10.1002/anie.201405014

The Impact of Continuous Flow Technology and Collaboration between Academia and Industry

Philip Jamieson, Ruairí Bannon, Davin Cronly, Megan Smyth, Scott Wharry, Thomas S. Moody, Gavin Lennon and Marcus Baumann

JACS Au, 2026, 6, 691
DOI: 10.1021/jacsau.5c01617

Continuous‐Flow Synthesis of ZIF‐8 Biocomposites with Tunable Particle Size

Francesco Carraro, Jason D. Williams, Mercedes Linares‐Moreau, Chiara Parise, Weibin Liang, Heinz Amenitsch, Christian Doonan, C. Oliver Kappe and Paolo Falcaro

Angew Chem Int Ed, 2020, 59, 8123
DOI: 10.1002/anie.202000678

Gas/Liquid‐Phase Micro‐Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N‐Sulfinylimines

Kazuki Hirano, Satoshi Gondo, Nagender Punna, Etsuko Tokunaga and Norio Shibata

ChemistryOpen, 2019, 8, 406
DOI: 10.1002/open.201800286

Advances in Continuous Flow Fluorination Reactions

Tsz Chun Lee, Yi Tong and Wai Chung Fu

Chemistry An Asian Journal, 2023, 18
DOI: 10.1002/asia.202300723

Expanding the medicinal chemistry synthetic toolbox

Jonas Boström, Dean G. Brown, Robert J. Young and György M. Keserü

Nat Rev Drug Discov, 2018, 17, 709
DOI: 10.1038/nrd.2018.116

Direct integration of gold-carbon nanotube hybrids in continuous-flow microfluidic chips: A versatile approach for nanocatalysis

Joseph Farah, Edmond Gravel, Eric Doris and Florent Malloggi

Journal of Colloid and Interface Science, 2022, 613, 359
DOI: 10.1016/j.jcis.2021.12.178

ChemInform Abstract: Flash Chemistry: Flow Chemistry That Cannot be Done in Batch

Jun‐ichi Yoshida, Yusuke Takahashi and Aiichiro Nagaki

ChemInform, 2013, 44
DOI: 10.1002/chin.201350255

Use of a “Catalytic” Cosolvent, N,N‐Dimethyl Octanamide, Allows the Flow Synthesis of Imatinib with no Solvent Switch

Jeffrey C. Yang, Dawen Niu, Bram P. Karsten, Fabio Lima and Stephen L. Buchwald

Angewandte Chemie, 2016, 128, 2577
DOI: 10.1002/ange.201509922

Towards More Efficient, Greener Syntheses through Flow Chemistry

Justin A.M. Lummiss, Peter D. Morse, Rachel L. Beingessner and Timothy F. Jamison

The Chemical Record, 2017, 17, 667
DOI: 10.1002/tcr.201600139

Large, Highly Modular Narrow-Gap Electrolytic Flow Cell and Application in Dehydrogenative Cross-Coupling of Phenols

Barbara Gleede, Maximilian Selt, Christoph Gütz, Andreas Stenglein and Siegfried R. Waldvogel

Org. Process Res. Dev., 2020, 24, 1916
DOI: 10.1021/acs.oprd.9b00451

Scaling continuous API synthesis from milligram to kilogram: extending the enabling benefits of micro to the plant

Mateo Berton, Juliana M. de Souza, Irini Abdiaj, D. Tyler McQuade and David R. Snead

J Flow Chem, 2020, 10, 73
DOI: 10.1007/s41981-019-00060-x

A Catalyst‐Free Amination of Functional Organolithium Reagents by Flow Chemistry

Heejin Kim, Yuya Yonekura and Jun‐ichi Yoshida

Angewandte Chemie, 2018, 130, 4127
DOI: 10.1002/ange.201713031

Developments in the Dehydrogenative Electrochemical Synthesis of 3,3′,5,5′‐Tetramethyl‐2,2′‐biphenol

Barbara Gleede, Maximilian Selt, Robert Franke and Siegfried R. Waldvogel

Chemistry A European J, 2021, 27, 8252
DOI: 10.1002/chem.202005197

Continuous‐/Micro‐Flow Reactions Using Highly Electrophilic PCl3 and POCl3

Hiroshi Kitamura and Shinichiro Fuse

ChemPlusChem, 2023, 88
DOI: 10.1002/cplu.202300176

Development and Scale-Up of a Continuous Reaction for Production of an Active Pharmaceutical Ingredient Intermediate

Jonathan P. McMullen, Christopher H. Marton, Benjamin D. Sherry, Glenn Spencer, Joseph Kukura and Natalie S. Eyke

Org. Process Res. Dev., 2018, 22, 1208
DOI: 10.1021/acs.oprd.8b00192

Continuous‐Flow Synthesis of ZIF‐8 Biocomposites with Tunable Particle Size

Francesco Carraro, Jason D. Williams, Mercedes Linares‐Moreau, Chiara Parise, Weibin Liang, Heinz Amenitsch, Christian Doonan, C. Oliver Kappe and Paolo Falcaro

Angewandte Chemie, 2020, 132, 8200
DOI: 10.1002/ange.202000678

Alkyllithium Compounds Bearing Electrophilic Functional Groups: A Flash Chemistry Approach

Aiichiro Nagaki, Hiroki Yamashita, Katsuyuki Hirose, Yuta Tsuchihashi and Jun‐ichi Yoshida

Angewandte Chemie, 2019, 131, 4067
DOI: 10.1002/ange.201814088

Advances in Continuous‐Flow Synthesis of Nitrogen‐Containing Heterocycles Through Sequence Transformations in the Past Decade (2016–2025)

Yi‐Jiang Guo, Zhao‐Yan Fu, Ai‐Rong She, Fei Wang, Chi‐Xian He and Teng Liu

Asian J Org Chem, 2025, 14
DOI: 10.1002/ajoc.202500614

Continuous Flow Technologies for the Synthesis of Pharmaceutically and Biologically Important Molecules: Update and Analysis

Yu‐kun Zhang, Eman Fayad, Dalal Nasser Binjawhar, Bing Sun and Hua‐Li Qin

ChemistrySelect, 2026, 11
DOI: 10.1002/slct.202505108

Photocatalytic and Electrochemical Borylation and Silylation Reactions

Tony Biremond, Margaux Riomet, Philippe Jubault and Thomas Poisson

The Chemical Record, 2023, 23
DOI: 10.1002/tcr.202300172

Preferential Formation of Squalene Monoepoxides via Microflow Reaction of Squalene and m-Chloroperbenzoic Acid

Tomoya Sho, Hidehisa Kawashima, Tadahiro Fujitani, Jun-Chul Choi and Masashi Kijima

Chemistry Letters, 2022, 51, 728
DOI: 10.1246/cl.220188

The assembly and use of continuous flow systems for chemical synthesis

Joshua Britton and Timothy F Jamison

Nat Protoc, 2017, 12, 2423
DOI: 10.1038/nprot.2017.102

Fully Automated Continuous Meso-flow Synthesis of 5′-Nucleotides and Deoxynucleotides

Chenjie Zhu, Chenglun Tang, Zhi Cao, Wei He, Yong Chen, Xiaochun Chen, Kai Guo and Hanjie Ying

Org. Process Res. Dev., 2014, 18, 1575
DOI: 10.1021/op5002066

Immobilized Iron Oxide Nanoparticles as Stable and Reusable Catalysts for Hydrazine‐Mediated Nitro Reductions in Continuous Flow

Mojtaba Mirhosseini Moghaddam, Bartholomäus Pieber, Toma Glasnov and C. Oliver Kappe

ChemSusChem, 2014, 7, 3122
DOI: 10.1002/cssc.201402455

Flow chemistry vs. flow analysis

Marek Trojanowicz

Talanta, 2016, 146, 621
DOI: 10.1016/j.talanta.2015.07.043

Development and Scale-up of a Flow Chemistry Lithiation–Borylation Route to a Key Boronic Acid Starting Material

Hirotsugu Usutani, Takashi Nihei, Charles D. Papageorgiou and David G. Cork

Org. Process Res. Dev., 2017, 21, 669
DOI: 10.1021/acs.oprd.7b00100

A Microfluidic Split-Flow Technology for Product Characterization in Continuous Low-Volume Nanoparticle Synthesis

Holger Bolze, Peer Erfle, Juliane Riewe, Heike Bunjes, Andreas Dietzel and Thomas P. Burg

Micromachines, 2019, 10, 179
DOI: 10.3390/mi10030179

Understanding of two-stage continuous microreaction technology for in-situ generation and consecutive conversion of diazomethane

Changfeng Yang, Yao Shi, Kuan He, Gang Qian, Leslaw Mleczko, Xuezhi Duan and Xinggui Zhou

Journal of the Taiwan Institute of Chemical Engineers, 2019, 98, 94
DOI: 10.1016/j.jtice.2018.06.022

Continuous-flow synthesis of di-(2-ethylhexyl) peroxydicarbonate in a packed-bed microreactor: Process optimization and kinetic modeling

Yushu Liu, Minjing Shang, Saier Liu, Xiao Xue, Zihao Zhong, Qiang Niu and Yuanhai Su

Chemical Engineering Science, 2024, 299, 120499
DOI: 10.1016/j.ces.2024.120499

Rapid and Mild Nucleophilic Substitution of a Highly Active (Indol-2-yl)methyl Electrophile in a Microflow Reactor

Shinichiro Fuse, Yuma Matsuura and Naoto Yamasaki

Synthesis, 2024, 56, 2663
DOI: 10.1055/s-0043-1775370

Flow Asymmetric Propargylation: Development of Continuous Processes for the Preparation of a Chiral β‐Amino Alcohol

Hui Li, Jillian W. Sheeran, Andrew M. Clausen, Yuan‐Qing Fang, Matthew M. Bio and Scott Bader

Angew Chem Int Ed, 2017, 56, 9425
DOI: 10.1002/anie.201704882

Multistep automated synthesis of pharmaceuticals

Gan Wang, Hwee Ting Ang, Srinivas Reddy Dubbaka, Patrick O’Neill and Jie Wu

Trends in Chemistry, 2023, 5, 432
DOI: 10.1016/j.trechm.2023.03.008

Suzuki–Miyaura Coupling Using Monolithic Pd Reactors and Scaling-Up by Series Connection of the Reactors

Aiichiro Nagaki, Katsuyuki Hirose, Yuya Moriwaki, Masahiro Takumi, Yusuke Takahashi, Koji Mitamura, Kimihiro Matsukawa, Norio Ishizuka and Jun-ichi Yoshida

Catalysts, 2019, 9, 300
DOI: 10.3390/catal9030300

Recent Advances in Continuous‐Flow Enantioselective Catalysis

Tao Yu, Zhengwei Ding, Wenzheng Nie, Jiao Jiao, Hailong Zhang, Qian Zhang, Chao Xue, Xinhua Duan, Yoichi M. A. Yamada and Pengfei Li

Chemistry A European J, 2020, 26, 5729
DOI: 10.1002/chem.201905151

Continuous flow protecting-group-free synthetic approach to thiol-terminated poly(ε-caprolactone)

Ning Zhu, Yihuan Liu, Weiyang Feng, Weijun Huang, Zilong Zhang, Xin Hu, Zheng Fang, Zhenjiang Li and Kai Guo

European Polymer Journal, 2016, 80, 234
DOI: 10.1016/j.eurpolymj.2016.04.010

Flow microreactor synthesis of 2,2-disubstituted oxetanes via 2-phenyloxetan-2-yl lithium

Leonardo Degennaro, Aiichiro Nagaki, Yuya Moriwaki, Giuseppe Romanazzi, Maria Michela DelľAnna, Jun-ichi Yoshida and Renzo Luisi

Open Chemistry, 2016, 14, 377
DOI: 10.1515/chem-2016-0041

Scale-Up and Optimization of a Continuous Flow Carboxylation of N-Boc-4,4-difluoropiperidine Using s-BuLi in THF

Jean-Paul Kestemont, James R. Frost, Jérôme Jacq, Patrick Pasau, Frédéric Perl, Julien Brown and Matthieu Tissot

Org. Process Res. Dev., 2022, 26, 635
DOI: 10.1021/acs.oprd.1c00092

Reproducible and rapid synthesis of a conjugated polymer by Stille polycondensation in flow: Effects of reaction parameters on molecular weight

Woojin Shin, Wonyoung Ko, Seung-Hwan Jin, Taeshik Earmme and Ye-Jin Hwang

Chemical Engineering Journal, 2021, 412, 128572
DOI: 10.1016/j.cej.2021.128572

“Snapshot” Trapping of Multiple Transient Azolyllithiums in Batch

Kengo Inoue, Yuxuan Feng, Atsunori Mori and Kentaro Okano

Chemistry A European J, 2021, 27, 10267
DOI: 10.1002/chem.202101256

Organozinc Reagents in a Flow-microreactor —From Methylenation to Asymmetric Autocatalysis—

Seijiro Matsubara

J. Syn. Org. Chem., Jpn., 2015, 73, 435
DOI: 10.5059/yukigoseikyokaishi.73.435

Chromatography as an inspiration for microreactors

Jonas Hereijgers, Tom Breugelmans and Wim De Malsche

J of Chemical Tech & Biotech, 2015, 90, 2122
DOI: 10.1002/jctb.4772

Microflow Synthesis of Unsymmetrical H-Phosphonates via Sequential and Direct Substitution of Chlorine Atoms in Phosphorus Trichloride with Alkoxy Groups

Yuma Tanaka, Hiroshi Kitamura and Shinichiro Fuse

J. Org. Chem., 2024, 89, 1777
DOI: 10.1021/acs.joc.3c02467

Chaotic-flow-driven mixing in T- and V-shaped micromixers

Shusaku Asano, Shinji Kudo and Jun-ichiro Hayashi

Chemical Engineering Journal, 2024, 489, 151183
DOI: 10.1016/j.cej.2024.151183

Harnessing [1,4], [1,5], and [1,6] Anionic Fries‐type Rearrangements by Reaction‐Time Control in Flow

Heejin Kim, Keita Inoue and Jun‐ichi Yoshida

Angew Chem Int Ed, 2017, 56, 7863
DOI: 10.1002/anie.201704006

Flash Colloidal Gold Nanoparticle Assembly in a Milli Flow System: Implications for Thermoplasmonic and for the Amplification of Optical Signals

Florent Voisin, Gérald Lelong, Jean-Michel Guigner, Thomas Bizien, Jean-Maurice Mallet and Florent Carn

ACS Appl. Nano Mater., 2022, 5, 6964
DOI: 10.1021/acsanm.2c00944

Enantiospecific cyclization of methyl N-(tert-butoxycarbonyl)-N-(3-chloropropyl)-D-alaninate to 2-methylproline derivative via ‘memory of chirality’ in flow

Gianvito Vilé, Gunther Schmidt, Sylvia Richard-Bildstein and Stefan Abele

J Flow Chem, 2019, 9, 19
DOI: 10.1007/s41981-018-0022-5

A Practical and General Amidation Method from Isocyanates Enabled by Flow Technology

Jason D. Williams, William J. Kerr, Stuart G. Leach and David M. Lindsay

Angew Chem Int Ed, 2018, 57, 12126
DOI: 10.1002/anie.201807393

Generation and Reaction of Carbamoyl Anions in Flow: Applications in the Three‐Component Synthesis of Functionalized α‐Ketoamides

Aiichiro Nagaki, Yusuke Takahashi and Jun‐ichi Yoshida

Angewandte Chemie, 2016, 128, 5413
DOI: 10.1002/ange.201601386

The Concept of Chemical Generators: On-Site On-Demand Production of Hazardous Reagents in Continuous Flow

Doris Dallinger, Bernhard Gutmann and C. Oliver Kappe

Acc. Chem. Res., 2020, 53, 1330
DOI: 10.1021/acs.accounts.0c00199

Environmentally Benign Flash Synthetic Chemistry Using Flow Microreactors

Aiichiro Nagaki

J. Synth. Org. Chem. Jpn., 2024, 82, 2
DOI: 10.5059/yukigoseikyokaishi.82.2

Toward the Identification of Intensified Reaction Conditions Using Response Surface Methodology: A Case Study on 3-Methylpyridine N-Oxide Synthesis

Jingyao Wang, Yanyan Huang, Benjamin A. Wilhite, Maria Papadaki and M. Sam Mannan

Ind. Eng. Chem. Res., 2019, 58, 6093
DOI: 10.1021/acs.iecr.8b03773

Fast Isomerization Before Isomerization‐Hydroformylation: Probing the Neglected Period with A Novel Microfluidic Device

Fanfu Guan, Yu Qian, Peiqi Zhang, Runtong Zhang, Xumu Zhang and Jialin Wen

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202302777

Conscious coupling: The challenges and opportunities of cascading enzymatic microreactors

Pia Gruber, Marco P. C. Marques, Brian O'Sullivan, Frank Baganz, Roland Wohlgemuth and Nicolas Szita

Biotechnology Journal, 2017, 12
DOI: 10.1002/biot.201700030

Thermal Decomposition of Ethyl Diazoacetate in Microtube Reactor: A Kinetics Study

Dawei Xin and Yangcheng Lu

ACS Omega, 2018, 3, 10526
DOI: 10.1021/acsomega.8b01521

Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers

Chengxi Li, Alex J. Callahan, Mark D. Simon, Kyle A. Totaro, Alexander J. Mijalis, Kruttika-Suhas Phadke, Genwei Zhang, Nina Hartrampf, Carly K. Schissel, Ming Zhou, Hong Zong, Gunnar J. Hanson, Andrei Loas, Nicola L. B. Pohl, David E. Verhoeven and Bradley L. Pentelute

Nat Commun, 2021, 12
DOI: 10.1038/s41467-021-24598-4

A Concise Flow Synthesis of Efavirenz

Camille A. Correia, Kerry Gilmore, D. Tyler McQuade and Peter H. Seeberger

Angew Chem Int Ed, 2015, 54, 4945
DOI: 10.1002/anie.201411728

Handling Hazards Using Continuous Flow Chemistry: Synthesis of N1-Aryl-[1,2,3]-triazoles from Anilines via Telescoped Three-Step Diazotization, Azidodediazotization, and [3 + 2] Dipolar Cycloaddition Processes

Matthieu Teci, Michael Tilley, Michael A. McGuire and Michael G. Organ

Org. Process Res. Dev., 2016, 20, 1967
DOI: 10.1021/acs.oprd.6b00292

An Efficient and Waste-Minimized One-Pot Procedure for the Preparation of N-Boc-γ-amino Alcohols Starting from α,β-Unsaturated Ketones in Flow

Eleonora Ballerini, Raimondo Maggi, Ferdinando Pizzo, Oriana Piermatti, Dmitri Gelman and Luigi Vaccaro

Org. Process Res. Dev., 2016, 20, 474
DOI: 10.1021/acs.oprd.5b00163

Use of a “Catalytic” Cosolvent, N,N‐Dimethyl Octanamide, Allows the Flow Synthesis of Imatinib with no Solvent Switch

Jeffrey C. Yang, Dawen Niu, Bram P. Karsten, Fabio Lima and Stephen L. Buchwald

Angew Chem Int Ed, 2016, 55, 2531
DOI: 10.1002/anie.201509922

Miniaturized and Automated Synthesis of Biomolecules—Overview and Perspectives

Daniela S. Mattes, Nicole Jung, Laura K. Weber, Stefan Bräse and Frank Breitling

Advanced Materials, 2019, 31
DOI: 10.1002/adma.201806656

Analysis of Stereochemical Stability of Dynamic Chiral Molecules Using an Automated Microflow Measurement System

Kazunobu Igawa, Shusaku Asano, Yuki Yoshida, Yuuya Kawasaki and Katsuhiko Tomooka

J. Org. Chem., 2021, 86, 9651
DOI: 10.1021/acs.joc.1c00914

A review on microreactors: Reactor fabrication, design, and cutting-edge applications

Prashant L. Suryawanshi, Sarang P. Gumfekar, Bharat A. Bhanvase, Shirish H. Sonawane and Makarand S. Pimplapure

Chemical Engineering Science, 2018, 189, 431
DOI: 10.1016/j.ces.2018.03.026

Scalable Subsecond Synthesis of Drug Scaffolds via Aryllithium Intermediates by Numbered-up 3D-Printed Metal Microreactors

Ji-Ho Kang, Gwang-Noh Ahn, Heekwon Lee, Se-Jun Yim, Santosh Lahore, Hyune-Jea Lee, Heejin Kim, Ji Tae Kim and Dong-Pyo Kim

ACS Cent. Sci., 2022, 8, 43
DOI: 10.1021/acscentsci.1c00972

Revisiting Hydroxyalkylation of Phenols with Cyclic Carbonates

Shih‐Chieh Kao, Yi‐Ching Lin, Ilhyong Ryu and Yen‐Ku Wu

Adv Synth Catal, 2019, 361, 3639
DOI: 10.1002/adsc.201900287

Iodine-Promoted Oxidative Cyclization of Acylated and Alkylated Derivatives from Epoxides toward the Synthesis of Aza Heterocycles

Alageswaran Jayaram, Karthick Govindan, Vijaya Raghavan Kannan, Vijay Thavasianandam Seenivasan, Nian-Qi Chen and Wei-Yu Lin

J. Org. Chem., 2023, 88, 1749
DOI: 10.1021/acs.joc.2c02802

Rapid and Mild Lactamization Using Highly Electrophilic Triphosgene in a Microflow Reactor

Shinichiro Fuse, Keiji Komuro, Yuma Otake, Hisashi Masui and Hiroyuki Nakamura

Chemistry A European J, 2021, 27, 7525
DOI: 10.1002/chem.202100059

Towards an approach to small-scale aryllithium flash flow chemistry using low-cost, low volume reactors

James A. K. Cochrane, Aaron J. Rigby and Raminder S. Mulla

J Flow Chem, 2024, 14, 667
DOI: 10.1007/s41981-024-00335-y

Enhanced Reaction Efficiency in Continuous Flow

Peter D. Morse, Rachel L. Beingessner and Timothy F. Jamison

Israel Journal of Chemistry, 2017, 57, 218
DOI: 10.1002/ijch.201600095

Direct C–H metallation of tetrahydrofuran and application in flow

Dongyong Kim, Hyune-Jea Lee, Yutaka Shimizu, Jun-ichi Yoshida and Heejin Kim

Nat. Synth, 2022, 1, 558
DOI: 10.1038/s44160-022-00100-w

Enabling Technologies for the Future of Chemical Synthesis

Daniel E. Fitzpatrick, Claudio Battilocchio and Steven V. Ley

ACS Cent. Sci., 2016, 2, 131
DOI: 10.1021/acscentsci.6b00015

One-Flow Syntheses of Unsymmetrical Sulfamides and N-Substituted Sulfamate Esters

Naoto Sugisawa, Kohei Nakabayashi, Hiroki Sugisawa and Shinichiro Fuse

Org. Lett., 2024, 26, 2739
DOI: 10.1021/acs.orglett.3c01546

Batch and Flow Synthesis of Pyrrolo[1,2-a]-quinolines via an Allene-Based Reaction Cascade

Marcus Baumann and Ian R. Baxendale

J. Org. Chem., 2015, 80, 10806
DOI: 10.1021/acs.joc.5b01982

Flow Chemistry on Multigram Scale: Continuous Synthesis of Boronic Acids within 1 s

Andreas Hafner, Mark Meisenbach and Joerg Sedelmeier

Org. Lett., 2016, 18, 3630
DOI: 10.1021/acs.orglett.6b01681

Flow Technology for Telescoped Generation, Lithiation and Electrophilic (C3) Functionalization of Highly Strained 1‐Azabicyclo[1.1.0]butanes

Pantaleo Musci, Timo von Keutz, Ferdinand Belaj, Leonardo Degennaro, David Cantillo, C. Oliver Kappe and Renzo Luisi

Angewandte Chemie, 2021, 133, 6465
DOI: 10.1002/ange.202014881

Rapid and Efficient Copper‐Catalyzed Finkelstein Reaction of (Hetero)Aromatics under Continuous‐Flow Conditions

Mao Chen, Saki Ichikawa and Stephen L. Buchwald

Angewandte Chemie, 2015, 127, 265
DOI: 10.1002/ange.201409595

Stirring the Debate: How Mixing Influences Reproducibility and Efficiency in Synthetic Organic Chemistry

Jasper H. A. Schuurmans, Stefan D. A. Zondag, Arnab Chaudhuri, John van der Schaaf and Timothy Noël

ACS Cent. Sci., 2026, 12, 7
DOI: 10.1021/acscentsci.5c01825

In Situ Generation of Trichloromethyl Anion and Efficient Reaction with Benzaldehyde in an Electrochemical Flow Microreactor

Yoshimasa Matsumura, Yoshiyuki Yamaji, Hiroyuki Tateno, Tsuneo Kashiwagi and Mahito Atobe

Chem. Lett., 2016, 45, 816
DOI: 10.1246/cl.160337

Precise analysis and control of polymerization kinetics using a micro flow reactor

Shusaku Asano, Taisuke Maki, Ryutaro Nakayama, Ryuji Utsunomiya, Yosuke Muranaka, Toshiharu Kuboyama and Kazuhiro Mae

Chemical Engineering and Processing: Process Intensification, 2017, 119, 73
DOI: 10.1016/j.cep.2017.05.016

Synthesis of Functionalized Ketones from Acid Chlorides and Organolithiums by Extremely Fast Micromixing

Aiichiro Nagaki, Kengo Sasatsuki, Satoshi Ishiuchi, Nobuyuki Miuchi, Masahiro Takumi and Jun‐ichi Yoshida

Chemistry A European J, 2019, 25, 4946
DOI: 10.1002/chem.201900743

Regioselective and Enantioselective Intermolecular Buchner Ring Expansions in Flow

Gabrielle S. Fleming and Aaron B. Beeler

Org. Lett., 2017, 19, 5268
DOI: 10.1021/acs.orglett.7b02537

Unprecedented yield of methyl-esterification with in-situ generated diazomethane in a microchannel reactor with methanol as solvent

Xuezhi Duan, Zikun Huang, Gang Qian, Kuan He, Jing Zhang, Leslaw Mleczko and Xinggui Zhou

Chemical Engineering Science, 2020, 213, 115397
DOI: 10.1016/j.ces.2019.115397

Development of a Continuous Flow Synthesis of 2-Substituted Azetines and 3-Substituted Azetidines by Using a Common Synthetic Precursor

Marco Colella, Pantaleo Musci, Debora Cannillo, Mauro Spennacchio, Andrea Aramini, Leonardo Degennaro and Renzo Luisi

J. Org. Chem., 2021, 86, 13943
DOI: 10.1021/acs.joc.1c01297

Matteson Reaction under Flow Conditions: Iterative Homologations of Terpenes

Conrad Kuhwald and Andreas Kirschning

Org. Lett., 2021, 23, 4300
DOI: 10.1021/acs.orglett.1c01222

Residence Time Distribution Characterization and Proof-of-Concept of a Novel Stacked 7-Stage Continuous Crystallizer Cascade with Diaphragm-Driven Slurry Transfer

Giovanni Aprile, Ajinkya V. Pandit, Jody Albertazzi, Thomas Vetter, Robert Viano, Lorenzo Milani, Andrea Adamo, Allan S. Myerson and Torsten Stelzer

Ind. Eng. Chem. Res., 2024, 63, 18199
DOI: 10.1021/acs.iecr.4c02153

Reactions of Difunctional Electrophiles with Functionalized Aryllithium Compounds: Remarkable Chemoselectivity by Flash Chemistry

Aiichiro Nagaki, Keita Imai, Satoshi Ishiuchi and Jun‐ichi Yoshida

Angew Chem Int Ed, 2015, 54, 1914
DOI: 10.1002/anie.201410717

Enhancement of mixing and reaction efficiency of various fluids applications at different microfluidic configuration and design

Whui Dhong Wong, Mohd Fadhil Majnis, Chin Wei Lai, Suresh Sagadevan and Nurhidayatullaili Muhd Julkapli

Chemical Engineering and Processing - Process Intensification, 2024, 198, 109729
DOI: 10.1016/j.cep.2024.109729

A Concise Flow Synthesis of the IKZF2 Glue Degrader DKY709

Xu You, Xu-Lun Huang, Hailong Ren, Chunrui Wu and Dahai Wang

Org. Process Res. Dev., 2025, 29, 1392
DOI: 10.1021/acs.oprd.4c00476

A Short Multistep Flow Synthesis of a Potential Spirocyclic Fragrance Component

Ian R. Baxendale

Chem Eng & Technol, 2015, 38, 1713
DOI: 10.1002/ceat.201500255

Synthesis of α-, β-, and γ-Amino Acids via the Photochemical and Electrochemical Carboxylation with CO2

Yong You and Tsuyoshi Mita

Synthesis, 2026
DOI: 10.1055/a-2835-2546

Efficient continuous-flow synthesis of diacyl peroxide in a microreactor and the post-processing of its effluent

Shunkai Xia, Tian Yang, Jianhong Xu and Zhuo Chen

Chemical Engineering Science, 2023, 281, 119140
DOI: 10.1016/j.ces.2023.119140

Facile Generation of tert-Butoxycarbonyl Chloride Equivalent and Its Use in Microflow Reactor

Kana Miyamoto, Ren Okabe and Shinichiro Fuse

Org. Process Res. Dev., 2024, 28, 1971
DOI: 10.1021/acs.oprd.4c00009

Coding the Assembly of Polyoxotungstates with a Programmable Reaction System

Andreu Ruiz de la Oliva, Victor Sans, Haralampos N. Miras, De-Liang Long and Leroy Cronin

Inorg. Chem., 2017, 56, 5089
DOI: 10.1021/acs.inorgchem.7b00206

Olefin Ring‐closing Metathesis under Spatial Confinement and Continuous Flow

Felix Ziegler, Thomas Roider, Markus Pyschik, Christian P. Haas, Dongren Wang, Ulrich Tallarek and Michael R. Buchmeiser

ChemCatChem, 2021, 13, 2234
DOI: 10.1002/cctc.202001993

A Flash Thermal Racemization Protocol for the Chemoenzymatic Dynamic Kinetic Resolution and Stereoinversion of Chiral Amines

Matthew J. Takle, Benjamin J. Deadman, Klaus Hellgardt, Joachim Dickhaut, Andy Wieja and King Kuok Mimi Hii

ACS Catal., 2023, 13, 10541
DOI: 10.1021/acscatal.3c02859

Kinetics Studies on a Multicomponent Knoevenagel−Michael Domino Reaction by an Automated Flow Reactor

Christian P. Haas and Ulrich Tallarek

ChemistryOpen, 2019, 8, 606
DOI: 10.1002/open.201900124

A Practical and General Amidation Method from Isocyanates Enabled by Flow Technology

Jason D. Williams, William J. Kerr, Stuart G. Leach and David M. Lindsay

Angewandte Chemie, 2018, 130, 12302
DOI: 10.1002/ange.201807393

Enhanced Controllability of Fries Rearrangements Using High‐Resolution 3D‐Printed Metal Microreactor with Circular Channel

Hyune‐Jea Lee, Robert C. Roberts, Do Jin Im, Se‐Jun Yim, Heejin Kim, Ji Tae Kim and Dong‐Pyo Kim

Small, 2019, 15
DOI: 10.1002/smll.201905005

Memory of Chirality in a Flow‐Based System: Enantioselective Synthesis of Quaternary α‐Amino Acids Using Flow Microreactors

Antonin Mambrini, Didier Gori, Cyrille Kouklovsky, Heejin Kim, Jun‐ichi Yoshida and Valérie Alezra

Eur J Org Chem, 2018, 2018, 6754
DOI: 10.1002/ejoc.201801305

Forbidden Chemistries — Paths to a Sustainable Future Engaging Continuous Processing

Bernhard Gutmann and C. Oliver Kappe

J Flow Chem, 2017, 7, 65
DOI: 10.1556/1846.2017.00009

The role of flow features and chemical kinetics on the reaction yield in a T-shaped micro-reactor

Alessandro Mariotti, Matteo Antognoli, Chiara Galletti, Roberto Mauri, Maria Vittoria Salvetti and Elisabetta Brunazzi

Chemical Engineering Journal, 2020, 396, 125223
DOI: 10.1016/j.cej.2020.125223

Organomagnesium Based Flash Chemistry: Continuous Flow Generation and Utilization of Halomethylmagnesium Intermediates

Timo von Keutz, David Cantillo and C. Oliver Kappe

Org. Lett., 2020, 22, 7537
DOI: 10.1021/acs.orglett.0c02725

Highly Selective Continuous‐Flow Synthesis of Potentially Bioactive Deuterated Chalcone Derivatives

Chi‐Ting Hsieh, Sándor B. Ötvös, Yang‐Chang Wu, István M. Mándity, Fang‐Rong Chang and Ferenc Fülöp

ChemPlusChem, 2015, 80, 859
DOI: 10.1002/cplu.201402426

Generation of Lithium Ethenolate by Lithiation of Tetrahydrofuran in Flow Mode

Parth Naik, Patrick O’Neill, Julia Bruno-Colmenarez and Marcus Baumann

Org. Process Res. Dev., 2025, 29, 2569
DOI: 10.1021/acs.oprd.5c00240

In Situ Reaction Monitoring of Unstable Lithiated Intermediates through Inline FTIR Spectroscopy

Verena Fath, Norbert Kockmann and Thorsten Röder

Chem Eng & Technol, 2019, 42, 2095
DOI: 10.1002/ceat.201900074

Anionic polymerization driven by flow microchemistry

Aiichiro Nagaki and Yosuke Ashikari

Polym J, 2025, 57, 143
DOI: 10.1038/s41428-024-00972-z

Unveiling Organocatalysts Action – Investigating Immobilized Catalysts at Steady‐State Operation via Lab‐on‐a‐Chip Technology

Hannes Westphal, Rico Warias, Holger Becker, Matthias Spanka, Daniele Ragno, Roger Gläser, Christoph Schneider, Alessandro Massi and Detlev Belder

ChemCatChem, 2021, 13, 5089
DOI: 10.1002/cctc.202101148

Size-dependent guest-memory switching of the flexible and robust adsorption characteristics of layered metal-organic frameworks

Satoshi Watanabe, Shotaro Hiraide, Homare Arima, Akiko Fukuta, Miyuki Mori, Hideki Tanaka and Minoru T. Miyahara

Sci. Adv., 2024, 10
DOI: 10.1126/sciadv.adr1387

Continuous Flow as Enabling Technology: Synthesis of Heteroaromatic Sulfinates as Bench Stable Cross-Coupling Partners

Fabio Lima, Jérôme André, Alexander Marziale, Andreas Greb, Susanne Glowienke, Mark Meisenbach, Berthold Schenkel, Benjamin Martin and Joerg Sedelmeier

Org. Lett., 2020, 22, 6082
DOI: 10.1021/acs.orglett.0c02155

Monolithiation of 5,5′‐Dibromo‐2,2′‐bithiophene Using Flow Microreactors: Mechanistic Implications and Synthetic Applications

Aiichiro Nagaki, Yiyuan Jiang, Hiroki Yamashita, Naoshi Takabayashi, Yusuke Takahashi and Jun-ichi Yoshida

Chem Eng & Technol, 2019, 42, 2113
DOI: 10.1002/ceat.201900057

Metal organic frameworks as solid catalyst for flow acetalization of benzaldehyde

Jia Jia, Chao Yang, Fujian Xu, Shuxia Xu and Xinfeng Zhang

Microchemical Journal, 2021, 165, 106113
DOI: 10.1016/j.microc.2021.106113

Automating drug discovery

Gisbert Schneider

Nat Rev Drug Discov, 2018, 17, 97
DOI: 10.1038/nrd.2017.232

Microfluidic continuous flow synthesis of 1,5-ditosyl-1,5-diazocane-3,7-dione using response surface methodology

Yang Zou, Tao Zhang, Guannan Wang, Mengwen Zhou, Yabo Xiong, Shaoyun Huang, Houbin Li and Xinghai Liu

Journal of Industrial and Engineering Chemistry, 2020, 82, 113
DOI: 10.1016/j.jiec.2019.10.002

Synthesis of Biaryls Having a Piperidylmethyl Group Based on Space Integration of Lithiation, Borylation, and Suzuki–Miyaura Coupling

Yusuke Takahashi, Yosuke Ashikari, Masahiro Takumi, Yutaka Shimizu, Yiyuan Jiang, Ryosuke Higuma, Susumu Ishikawa, Hodaka Sakaue, Ibuki Shite, Kei Maekawa, Yoko Aizawa, Hiroki Yamashita, Yuya Yonekura, Marco Colella, Renzo Luisi, Toshihiro Takegawa, Chiemi Fujita and Aiichiro Nagaki

Eur J Org Chem, 2020, 2020, 618
DOI: 10.1002/ejoc.201901729

An Efficient Partial Reduction of α,β‐Unsaturated Esters Using DIBAL‐H in Flow

Masahito Yoshida, Hiroyuki Otaka and Takayuki Doi

Eur J Org Chem, 2014, 2014, 6010
DOI: 10.1002/ejoc.201402675

Microfluidic Aqueous Two-Phase Focusing of Chemical Species for In Situ Subcellular Stimulation

Qiang Zhang, Tianze Xie, Xizhen Yi, Gaowa Xing, Shuo Feng, Shulang Chen, Yuxuan Li and Jin-Ming Lin

ACS Appl. Mater. Interfaces, 2023, 15, 45640
DOI: 10.1021/acsami.3c09665

Chemische Fertigungssysteme: Kontrolle auf mehreren Ebenen für die divergente, kontinuierliche und vielstufige Synthese von pharmazeutisch aktiven Wirkstoffen

Diego Ghislieri, Kerry Gilmore and Peter H. Seeberger

Angewandte Chemie, 2015, 127, 688
DOI: 10.1002/ange.201409765

Continuous‐Flow Divergent Lithiation of 2,3‐Dihalopyridines: Deprotolithiation versus Halogen Dance

Thibaud Brégent, Maria V. Ivanova, Thomas Poisson, Philippe Jubault and Julien Legros

Chemistry A European J, 2022, 28
DOI: 10.1002/chem.202202286

Continuous flow chemistry for molecular synthesis

Sarah E. Raby-Buck, Jonathan Devlin, Prachi Gupta, Claudio Battilocchio, Marcus Baumann, Anastasios Polyzos, Anna G. Slater and Duncan L. Browne

Nat Rev Methods Primers, 2025, 5
DOI: 10.1038/s43586-025-00414-x

Heterogeneous photocatalysis in flow chemical reactors

Christopher G Thomson, Ai-Lan Lee and Filipe Vilela

Beilstein J. Org. Chem., 2020, 16, 1495
DOI: 10.3762/bjoc.16.125

Controlled Transformations of Aryl Halides in a Flow System: Selective Synthesis of Aryl Azides and Aniline Derivatives

Ádám Georgiádes, Sándor B. Ötvös and Ferenc Fülöp

Adv Synth Catal, 2018, 360, 1841
DOI: 10.1002/adsc.201701539

Integrated One‐Flow Synthesis of Heterocyclic Thioquinazolinones through Serial Microreactions with Two Organolithium Intermediates

Heejin Kim, Hyune‐Jea Lee and Dong‐Pyo Kim

Angewandte Chemie, 2015, 127, 1897
DOI: 10.1002/ange.201410062

Microflow Fluorinations of Benzynes: Efficient Synthesis of Fluoroaromatic Compounds

Takashi Ikawa, Shigeaki Masuda and Shuji Akai

Chem. Pharm. Bull., 2018, 66, 1153
DOI: 10.1248/cpb.c18-00578

Process parameter and kinetic study for the azidation of a zidovudine intermediate with sodium azide in microreactors

Rongkun Jiang, Xiao Xue, Fang Zhao, Weiping Zhu, Minjing Shang, Yuanhai Su, Yufang Xu and Xuhong Qian

Chemical Engineering Journal, 2022, 429, 132207
DOI: 10.1016/j.cej.2021.132207

Bismuth(III)-Catalyzed Hydration of Terminal Alkynes: Sustainable Synthesis of Methyl Ketones in Batch and Flow

Sándor B. Ötvös, Zsanett Szécsényi and Ferenc Fülöp

ACS Sustainable Chem. Eng., 2019, 7, 13286
DOI: 10.1021/acssuschemeng.9b02520

Scalable and Sustainable Synthesis of Advanced Porous Materials

Shing Bo Peh, Yuxiang Wang and Dan Zhao

ACS Sustainable Chem. Eng., 2019, 7, 3647
DOI: 10.1021/acssuschemeng.8b05463

Recent Progress in Continuous‐Flow Hydrogenation

Tao Yu, Jiao Jiao, Peidong Song, Wenzheng Nie, Chunhai Yi, Qian Zhang and Pengfei Li

ChemSusChem, 2020, 13, 2876
DOI: 10.1002/cssc.202000778

A Catalyst‐Free Amination of Functional Organolithium Reagents by Flow Chemistry

Heejin Kim, Yuya Yonekura and Jun‐ichi Yoshida

Angew Chem Int Ed, 2018, 57, 4063
DOI: 10.1002/anie.201713031

Efficient Kinetic Data Acquisition and Model Prediction: Continuous Flow Microreactors, Inline Fourier Transform Infrared Spectroscopy, and Self-Modeling Curve Resolution

Verena Fath, Philipp Lau, Christoph Greve, Norbert Kockmann and Thorsten Röder

Org. Process Res. Dev., 2020, 24, 1955
DOI: 10.1021/acs.oprd.0c00037

Fluoroform upcycling to trifluorovinylamine as a C2 reagent to prepare difluoromethylated molecules

Pavel Ivashkin, Jonathan Decaens, Isabelle Marchand, Matthieu Hedouin, Hassan Oulyadi, Thomas Poisson and Philippe Jubault

Nat. Synth, 2026
DOI: 10.1038/s44160-026-01001-y

Flow‐Assisted Synthesis of [10]Cycloparaphenylene through Serial Microreactions under Mild Conditions

Heejin Kim, Hyune‐Jea Lee and Dong‐Pyo Kim

Angew Chem Int Ed, 2016, 55, 1422
DOI: 10.1002/anie.201509748

Gas-liquid flow hydrogenation of nitroarenes: Efficient access to a pharmaceutically relevant pyrrolobenzo[1,4]diazepine scaffold

Eleni Dimitriou, Richard H. Jones, Robin G. Pritchard, Gavin J. Miller and Matthew O'Brien

Tetrahedron, 2018, 74, 6795
DOI: 10.1016/j.tet.2018.09.025

Electrosynthesis in Laminar Flow Using a Flow Microreactor

Naoki Shida, Yuto Nakamura and Mahito Atobe

The Chemical Record, 2021, 21, 2164
DOI: 10.1002/tcr.202100016

Chemical-Resistant Green Luminescent Concentrator-Based Photo-Microreactor via One-Touch Assembly of 3D-Printed Modules

Gwang-Noh Ahn, Mi-Jeong Kim, Se-Jun Yim, Brijesh M. Sharma and Dong-Pyo Kim

ACS Sustainable Chem. Eng., 2022, 10, 3951
DOI: 10.1021/acssuschemeng.1c08240

Rapid On-Demand Synthesis of Lomustine under Continuous Flow Conditions

Zinia Jaman, Tiago J. P. Sobreira, Ahmed Mufti, Christina R. Ferreira, R. Graham Cooks and David H. Thompson

Org. Process Res. Dev., 2019, 23, 334
DOI: 10.1021/acs.oprd.8b00387

Strategic Application of Residence‐Time Control in Continuous‐Flow Reactors

István M. Mándity, Sándor B. Ötvös and Ferenc Fülöp

ChemistryOpen, 2015, 4, 212
DOI: 10.1002/open.201500018

Direct Synthesis of Hydroquinones from Quinones through Sequential and Continuous‐Flow Hydrogenation‐Derivatization Using Heterogeneous Au–Pt Nanoparticles as Catalysts

Hiroyuki Miyamura, Fumiya Tobita, Aya Suzuki and Shū Kobayashi

Angewandte Chemie, 2019, 131, 9318
DOI: 10.1002/ange.201904159

A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow

Hongkun Lin, Chunhui Dai, Timothy F. Jamison and Klavs F. Jensen

Angew Chem Int Ed, 2017, 56, 8870
DOI: 10.1002/anie.201703812

Continuous Flow Photocatalysis for Sustainable Chemical Conversions

Sitong Feng, Wanjun Shi, Tingbin Lim, Emma Richards and Ren Su

JACS Au, 2026, 6, 1424
DOI: 10.1021/jacsau.5c01612

Three-Component Coupling Based on Flash Chemistry. Carbolithiation of Benzyne with Functionalized Aryllithiums Followed by Reactions with Electrophiles

Aiichiro Nagaki, Daisuke Ichinari and Jun-ichi Yoshida

J. Am. Chem. Soc., 2014, 136, 12245
DOI: 10.1021/ja5071762

A layered double hydroxide, a synthetically useful heterogeneous catalyst for azide−alkyne cycloadditions in a continuous-flow reactor

Sándor B. Ötvös, Ádám Georgiádes, Mónika Ádok-Sipiczki, Rebeka Mészáros, István Pálinkó, Pál Sipos and Ferenc Fülöp

Applied Catalysis A: General, 2015, 501, 63
DOI: 10.1016/j.apcata.2015.05.003

Residence time characteristic of Taylor reacting flow in a microchannel reactor

Hao Feng, Ying Zhang, Dong Liu and Rong Chen

Chemical Engineering Science, 2022, 253, 117575
DOI: 10.1016/j.ces.2022.117575

Continuous Production of Lipid Nanoparticles by Ultrasound‐Assisted Microfluidic Antisolvent Precipitation

Holger Bolze, Juliane Riewe, Heike Bunjes, Andreas Dietzel and Thomas P. Burg

Chem Eng & Technol, 2021, 44, 1641
DOI: 10.1002/ceat.202100149

A chemoselective and continuous synthesis of m-sulfamoylbenzamide analogues

Arno Verlee, Thomas Heugebaert, Tom van der Meer, Pavel I Kerchev, Frank Van Breusegem and Christian V Stevens

Beilstein J. Org. Chem., 2017, 13, 303
DOI: 10.3762/bjoc.13.33

Efficient and safe continuous synthesis and post-processing of 1,1-bis(tert-butylperoxy)cyclohexane in a microreaction system

Hao Lu, Shunkai Xia, Kang Qin, Jilei Han, Zhuo Chen and Jianhong Xu

Chemical Engineering Science, 2026, 320, 122630
DOI: 10.1016/j.ces.2025.122630

Fast and Efficient Continuous Flow Method for the Synthesis of Ynones and Pyrazoles

Mohanraj Kandasamy, Balaji Ganesan, Min‐Yuan Hung and Wei‐Yu Lin

Eur J Org Chem, 2019, 2019, 3183
DOI: 10.1002/ejoc.201900468

Rapid and Efficient Copper‐Catalyzed Finkelstein Reaction of (Hetero)Aromatics under Continuous‐Flow Conditions

Mao Chen, Saki Ichikawa and Stephen L. Buchwald

Angew Chem Int Ed, 2015, 54, 263
DOI: 10.1002/anie.201409595

Obtaining Kinetics From Continuous Processes: Sampling Multiple Time Points Concurrently With a Single Valve Rotation

Mathieu A. Morin, Debasis Mallik, Wenyao Zhang, William Pietro, Jeffrey M. Manthorpe and Michael G. Organ

Chemistry Methods, 2021, 1, 131
DOI: 10.1002/cmtd.202100003

A fully automated flow-based approach for accelerated peptide synthesis

Alexander J Mijalis, Dale A Thomas, Mark D Simon, Andrea Adamo, Ryan Beaumont, Klavs F Jensen and Bradley L Pentelute

Nat Chem Biol, 2017, 13, 464
DOI: 10.1038/nchembio.2318

Study for diastereoselective aldol reaction in flow: synthesis of (E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid, a key component of cyclodepsipeptide HDAC inhibitors

Takayuki Doi, Hiroyuki Otaka, Koji Umeda and Masahito Yoshida

Tetrahedron, 2015, 71, 6463
DOI: 10.1016/j.tet.2015.05.051

Exploring ultrafast flow chemistry by autonomous self-optimizing platform

Gwang-Noh Ahn, Ji-Ho Kang, Hyune-Jea Lee, Byung Eon Park, Minjun Kwon, Gi-Su Na, Heejin Kim, Dong-Hwa Seo and Dong-Pyo Kim

Chemical Engineering Journal, 2023, 453, 139707
DOI: 10.1016/j.cej.2022.139707

Integrated Flow Emulsion Electrosynthetic System by In Situ Generation of Emulsions, Subsequent Emulsion Electrolysis, and Final Phase Separation

Rio Mikami, Naoki Shida and Mahito Atobe

Org. Process Res. Dev., 2022, 26, 1268
DOI: 10.1021/acs.oprd.2c00004

Machine‐Assisted Organic Synthesis

Steven V. Ley, Daniel E. Fitzpatrick, Rebecca M. Myers, Claudio Battilocchio and Richard. J. Ingham

Angew Chem Int Ed, 2015, 54, 10122
DOI: 10.1002/anie.201501618

Harnessing [1,4], [1,5], and [1,6] Anionic Fries‐type Rearrangements by Reaction‐Time Control in Flow

Heejin Kim, Keita Inoue and Jun‐ichi Yoshida

Angewandte Chemie, 2017, 129, 7971
DOI: 10.1002/ange.201704006

Generation and Reaction of Carbamoyl Anions in Flow: Applications in the Three‐Component Synthesis of Functionalized α‐Ketoamides

Aiichiro Nagaki, Yusuke Takahashi and Jun‐ichi Yoshida

Angew Chem Int Ed, 2016, 55, 5327
DOI: 10.1002/anie.201601386

Light-Controlled Radical Polymerization: Mechanisms, Methods, and Applications

Mao Chen, Mingjiang Zhong and Jeremiah A. Johnson

Chem. Rev., 2016, 116, 10167
DOI: 10.1021/acs.chemrev.5b00671

Generating cis-aza-diaryl and triaryl ethers via organoBrønsted acid catalysed aza-Darzens chemistry

Sean P. Bew, Simon J. Coles, Mateusz B. Pitak, Wim T. Klooster, Polly-Anna Ashford and Victor Zdorichenko

Tetrahedron, 2019, 75, 130532
DOI: 10.1016/j.tet.2019.130532

Continuous-Flow Synthesis of Deuterium-Labeled Antidiabetic Chalcones: Studies towards the Selective Deuteration of the Alkynone Core

Sándor Ötvös, Chi-Ting Hsieh, Yang-Chang Wu, Jih-Heng Li, Fang-Rong Chang and Ferenc Fülöp

Molecules, 2016, 21, 318
DOI: 10.3390/molecules21030318

Batch Versus Flow Lithiation–Substitution of 1,3,4‐Oxadiazoles: Exploitation of Unstable Intermediates Using Flow Chemistry

Jeff Y. F. Wong, John M. Tobin, Filipe Vilela and Graeme Barker

Chemistry A European J, 2019, 25, 12439
DOI: 10.1002/chem.201902917

Main Group Metal‐Mediated Transformations of Imines

Samantha A. Orr, Philip C. Andrews and Victoria L. Blair

Chemistry A European J, 2021, 27, 2569
DOI: 10.1002/chem.202003108

Simulation of reactive mixing behaviors inside micro-droplets by a lattice Boltzmann method

Yuhang Fu, Lin Bai, Shufang Zhao, Xiong Zhang, Yong Jin and Yi Cheng

Chemical Engineering Science, 2018, 181, 79
DOI: 10.1016/j.ces.2018.02.010

Continuous Flow Synthesis of Ketones from Carbon Dioxide and Organolithium or Grignard Reagents

Jie Wu, Xiaoqing Yang, Zhi He, Xianwen Mao, T. Alan Hatton and Timothy F. Jamison

Angewandte Chemie, 2014, 126, 8556
DOI: 10.1002/ange.201405014

Metal Films from a Single Source and Their Application in Nanoporous Filtration Synthesis, Electromagnetic Interference Shielding, and Electroadhesion

Muthupandi Veerasubash, Sarika Hanamant Birajdar, Sharmin Percy Kika, Marimuthu Senthilkumaran, Karan Deshpande, Rahul Shevate and Kothandam Krishnamoorthy

ACS Omega, 2026, 11, 14203
DOI: 10.1021/acsomega.4c07730

Sustainable supramolecular synthesis in flow

Thomas West

Nat. Synth, 2024, 3, 137
DOI: 10.1038/s44160-023-00440-1

One-Step Synthesis of 2-Fluoroadenine Using Hydrogen Fluoride Pyridine in a Continuous Flow Operation

Nastaran Salehi Marzijarani, David R. Snead, Jonathan P. McMullen, François Lévesque, Mark Weisel, Richard J. Varsolona, Yu-hong Lam, Zhijian Liu and John R. Naber

Org. Process Res. Dev., 2019, 23, 1522
DOI: 10.1021/acs.oprd.9b00178

Harnessing a Continuous‐Flow Persulfuric Acid Generator for Direct Oxidative Aldehyde Esterifications

Bence S. Nagy, Gang Fu, Christopher A. Hone, C. Oliver Kappe and Sándor B. Ötvös

ChemSusChem, 2023, 16
DOI: 10.1002/cssc.202201868

Process intensification

Frerich J. Keil

Reviews in Chemical Engineering, 2018, 34, 135
DOI: 10.1515/revce-2017-0085

Exploring Flow Procedures for Diazonium Formation

Te Hu, Ian Baxendale and Marcus Baumann

Molecules, 2016, 21, 918
DOI: 10.3390/molecules21070918

Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry

Andrew R. Bogdan and Amanda W. Dombrowski

J. Med. Chem., 2019, 62, 6422
DOI: 10.1021/acs.jmedchem.8b01760

Alkyllithium Compounds Bearing Electrophilic Functional Groups: A Flash Chemistry Approach

Aiichiro Nagaki, Hiroki Yamashita, Katsuyuki Hirose, Yuta Tsuchihashi and Jun‐ichi Yoshida

Angew Chem Int Ed, 2019, 58, 4027
DOI: 10.1002/anie.201814088

Heterogeneous Microfluidic Reactors: A Review and an Insight of Enzymatic Reactions

Fiona W. M. Ling, Hayder A. Abdulbari and Sim Yee Chin

ChemBioEng Reviews, 2022, 9, 265
DOI: 10.1002/cben.202100058

Telescoped lithiation, C-arylation and methoxylation in flow-batch hybrid toward the synthesis of canagliflozin

Dominik Polterauer, Jason D. Williams, Christopher A. Hone and C. Oliver Kappe

Tetrahedron Letters, 2021, 82, 153351
DOI: 10.1016/j.tetlet.2021.153351

A Simple Scale-up Strategy for Organolithium Chemistry in Flow Mode: From Feasibility to Kilogram Quantities

Andreas Hafner, Paolo Filipponi, Lorenzo Piccioni, Mark Meisenbach, Berthold Schenkel, Francesco Venturoni and Joerg Sedelmeier

Org. Process Res. Dev., 2016, 20, 1833
DOI: 10.1021/acs.oprd.6b00281

Microreactor Technology: Identifying Focus Fields and Emerging Trends by Using CiteSpace II

Lin Yang, Yutao Sun and Lijing Zhang

ChemPlusChem, 2023, 88
DOI: 10.1002/cplu.202200349

Enhanced fluid mixing in a T-shaped microchannel using oscillatory pressure modulation

S.E. Sas, D.E. Roshchin and S.A. Patlazhan

International Journal of Heat and Fluid Flow, 2026, 117, 110102
DOI: 10.1016/j.ijheatfluidflow.2025.110102

From ‘Lab & Light on a Chip’ to Parallel Microflow Photochemistry

Michael Oelgemöller, Norbert Hoffmann and Oksana Shvydkiv

Australian Journal of Chemistry, 2014, 67, 337
DOI: 10.1071/CH13591

Flow‐Chemistry‐Enabled Synthesis of 5‐Diethylboryl‐2,3′‐bipyridine and Its Self‐Assembly Dynamics

Shigeharu Wakabayashi, Masahiro Takumi, Shintaro Kamio, Masayuki Wakioka, Yasuhiro Ohki and Aiichiro Nagaki

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202202882