Issue 15, 2024

Advancements in the development of fluorescent chemosensors based on C[double bond, length as m-dash]N bond isomerization/modulation mechanistic approaches

Abstract

The C[double bond, length as m-dash]N bond isomerization/modulation as a fluorescence signalling mechanism was explored by studying the photophysical properties of conformationally restricted molecules. From the beginning, the C[double bond, length as m-dash]N bond isomerization method has attracted the attention of researchers owing to its simplicity, high selectivity, and sensitivity in fluorescence evaluation. Continuous developments in the field of sensing using C[double bond, length as m-dash]N bond-containing compounds have been achieved via the customization of the isomerization process around the C[double bond, length as m-dash]N bond in numerous ways, and the results were obtained in the form of specific discrete photophysical changes. C[double bond, length as m-dash]N isomerization causes significant fluorescence enhancement in response to detected metal cations and other reactive species (Cys, Hys, ClO, etc.) straightforwardly and effectively. This review sheds light on the process of C[double bond, length as m-dash]N bond isomerization/modulation as a signalling mechanism depending on fluorescence changes via conformational restriction. In addition, C[double bond, length as m-dash]N bond isomerization-based fluorescent sensors have yet to be well reviewed, although several fluorescent sensors based on this signalling mechanism have been reported. Therefore, C[double bond, length as m-dash]N-based fluorescent sensors are summarized in this review.

Graphical abstract: Advancements in the development of fluorescent chemosensors based on C [[double bond, length as m-dash]] N bond isomerization/modulation mechanistic approaches

Article information

Article type
Critical Review
Submitted
27 dec 2023
Accepted
11 mar 2024
First published
15 mar 2024

Anal. Methods, 2024,16, 2198-2228

Advancements in the development of fluorescent chemosensors based on C[double bond, length as m-dash]N bond isomerization/modulation mechanistic approaches

A. Tamrakar, M. A. Wani, G. Mishra, A. Srivastava, R. Pandey and M. D. Pandey, Anal. Methods, 2024, 16, 2198 DOI: 10.1039/D3AY02321D

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