Issue 19, 2022

High-efficiency brain-targeted intranasal delivery of BDNF mediated by engineered exosomes to promote remyelination

Abstract

The regeneration of myelin sheaths is the ultimate goal of the treatment of demyelination disease, including multiple sclerosis (MS). However, current drugs for MS mainly target the immune system and can only slow down the disease development and do not promote the differentiation of oligodendrocyte precursor cells (OPCs) abundant in the myelin injury region into mature oligodendrocytes to form a new myelin sheath. Brain-derived neurotrophic factor (BDNF) plays an important role in the regulation of OPC proliferation and differentiation into mature oligodendrocytes. Exosomes, a kind of nanoscale membrane vesicle secreted by cells, can be used as potential therapeutic drug delivery vectors for central nervous system diseases. Here, brain-targeted modification and BDNF intracellular-loaded exosomes were produced through engineering HEK293T cells, which can promote the differentiation of OPCs into mature oligodendrocytes in vitro. The intranasal administration of the brain-targeted engineered exosome-mediated BDNF was a highly effective delivery route to the brain and had a significant therapeutic effect on remyelination and motor coordination ability improvement in demyelination model mice. The combination of intranasal administration with brain-targeted and BDNF-loaded designed exosomes provides a strategy for efficient drug delivery and treatment of central nervous system diseases.

Graphical abstract: High-efficiency brain-targeted intranasal delivery of BDNF mediated by engineered exosomes to promote remyelination

Supplementary files

Article information

Article type
Paper
Submitted
05 apr 2022
Accepted
06 aug 2022
First published
10 aug 2022

Biomater. Sci., 2022,10, 5707-5718

High-efficiency brain-targeted intranasal delivery of BDNF mediated by engineered exosomes to promote remyelination

Y. Zhai, Q. Wang, Z. Zhu, Y. Hao, F. Han, J. Hong, W. Zheng, S. Ma, L. Yang and G. Cheng, Biomater. Sci., 2022, 10, 5707 DOI: 10.1039/D2BM00518B

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