Issue 28, 2015

In situ Raman mapping for identifying transient solid forms

Abstract

Paracetamol trihydrate is a highly unstable form which undergoes a rapid phase transformation to its stable anhydrous polymorph I. In situ Raman surface mapping on a trihydrate sample provides evidence for the existence of a transient phase on the route to its stable polymorph I. The transient phase showed significant spectral differences from those of known polymorphs, the trihydrate and amorphous forms, and is tentatively assigned to the monohydrate form on the basis of the observed crystallite morphology.

Graphical abstract: In situ Raman mapping for identifying transient solid forms

  • This article is part of the themed collection: Polymorphism

Supplementary files

Article information

Article type
Paper
Submitted
02 jan 2015
Accepted
24 mar 2015
First published
26 mar 2015

CrystEngComm, 2015,17, 5280-5287

Author version available

In situ Raman mapping for identifying transient solid forms

J. B. Nanubolu and J. C. Burley, CrystEngComm, 2015, 17, 5280 DOI: 10.1039/C5CE00008D

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