An AIE photosensitizer with type I/II ROS generation for photodynamic therapy of toxoplasmosis

Jiating Chen; Wen Li; Rulong Chen; Tingfei Xie; Jinxin Zhang; Jiahui Chen; Xiaolu Sui; Pengfei Zhang; Jihong Chen

doi:10.1039/D5CC04690D

An AIE photosensitizer with type I/II ROS generation for photodynamic therapy of toxoplasmosis

Jiating Chen,^a Wen Li,^b Rulong Chen,

^a Tingfei Xie,^a Jinxin Zhang,^a Jiahui Chen,^a Xiaolu Sui,^a Pengfei Zhang

*^c and Jihong Chen*^a

Author affiliations

* Corresponding authors

^a Department of Nephrology, The People's Hospital of Baoan Shenzhen, The Second Affiliated Hospital of Shenzhen University, Shenzhen Hospital of Guangdong Provincial People's Hospital, Shenzhen School of Clinical Medicine, Southern Medical University, Shenzhen Baoan Clinical Medical School of Guangdong Medical University, The 8th people's Hospital of Shenzhen, Baoan Clinical Research Center for Kidney Disease, Guangdong 518000, P. R. China
E-mail: chenjihong0606@hotmail.com

^b College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China

^c Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, Shenzhen Key Laboratory of Metabolic Health, Shenzhen Metabolism and Reproductive Targeted Delivery Proof-of-Concept Center, CAS Key Lab for Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
E-mail: pf.zhang@siat.ac.cn

Abstract

Toxoplasmosis, a global parasitic disease threatening one-third of humans, lacks effective treatments. We developed a mitochondrion-targeting AIE photosensitizer (AIEPS) generating dual type I/II ROS, enabling light-activated eradication of Toxoplasma gondii and offering a potent photodynamic therapy against toxoplasmosis.

This article is part of the themed collection: Aggregation-Induced Emission

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DOI: https://doi.org/10.1039/D5CC04690D
Article type: Communication
Submitted: 14 Aug 2025
Accepted: 18 Dec 2025
First published: 23 Dec 2025

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Chem. Commun., 2026, Advance Article

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An AIE photosensitizer with type I/II ROS generation for photodynamic therapy of toxoplasmosis

J. Chen, W. Li, R. Chen, T. Xie, J. Zhang, J. Chen, X. Sui, P. Zhang and J. Chen, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D5CC04690D

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Chemical Communications

An AIE photosensitizer with type I/II ROS generation for photodynamic therapy of toxoplasmosis

Abstract

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An AIE photosensitizer with type I/II ROS generation for photodynamic therapy of toxoplasmosis

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