Issue 48, 2024

Construction of photofunctional peptide conjugates through selective modification of N-terminal cysteine with cyclometallated iridium(iii) 2-formylphenylboronic acid complexes for organelle-specific imaging, enzyme activity sensing and photodynamic therapy

Abstract

Luminescent cyclometallated iridium(III) complexes bearing a 2-formylphenylboronic acid moiety were designed; one of the complexes was utilised to modify peptides containing an N-terminal cysteine to afford luminescent conjugates with selective organelle-targeting or furin-responsive properties.

Graphical abstract: Construction of photofunctional peptide conjugates through selective modification of N-terminal cysteine with cyclometallated iridium(iii) 2-formylphenylboronic acid complexes for organelle-specific imaging, enzyme activity sensing and photodynamic therapy

Supplementary files

Article information

Article type
Communication
Submitted
17 apr 2024
Accepted
10 maj 2024
First published
10 maj 2024

Chem. Commun., 2024,60, 6186-6189

Construction of photofunctional peptide conjugates through selective modification of N-terminal cysteine with cyclometallated iridium(III) 2-formylphenylboronic acid complexes for organelle-specific imaging, enzyme activity sensing and photodynamic therapy

L. Huang, L. C. Lee, J. Shum, G. Xu and K. K. Lo, Chem. Commun., 2024, 60, 6186 DOI: 10.1039/D4CC01824A

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