Issue 3, 2024

Natural products applied in acute kidney injury treatment: polymer matters

Abstract

Acute kidney injury (AKI) is a global health threat due to its high morbidity and mortality. There is still a lack of effective therapeutic methods to deal with AKI clinically. Natural products with outstanding accessibility and bioactivity are potential candidates for AKI treatment. Natural product-based prodrugs or nano-structures with improved properties are frequently fabricated for maximizing bioavailability and decreasing side effects, in which natural polymers are selected as carriers, or natural drugs are loaded as cargos on designed polymers. In this review, the etiologies of AKI are briefly presented, and emerging natural products delivered rationally for AKI therapy, as either carriers or cargos, are both introduced. Moreover, the challenges of the future development of nature-based nanodrugs or prodrugs for AKI have also been discussed.

Graphical abstract: Natural products applied in acute kidney injury treatment: polymer matters

Article information

Article type
Minireview
Submitted
31 okt 2023
Accepted
06 dec 2023
First published
06 dec 2023

Biomater. Sci., 2024,12, 621-633

Natural products applied in acute kidney injury treatment: polymer matters

B. Yu, Q. Jin and J. Ji, Biomater. Sci., 2024, 12, 621 DOI: 10.1039/D3BM01772A

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