Issue 15, 2023

Nanoscale MOFs in nanomedicine applications: from drug delivery to therapeutic agents

Abstract

Metal–organic frameworks (MOFs) hold great promise for widespread applications in biomedicine and nanomedicine. MOFs are one of the most fascinating nanocarriers for drug delivery, benefiting from their high porosity and facile modification. Furthermore, the tailored components of MOFs can be therapeutic agents for various treatments, including drugs as organic ligands of MOFs, active metal as central metal ions of MOFs, and their combinations as carrier-free MOF-based nanodrug. In this review, the advances in delivery systems and applications as therapeutic agents for nanoscale MOF-based materials are summarized. The challenges of MOFs in clinical translation and the future directions in the field of MOFs therapy are also discussed. We hope that more researchers will focus their attention on advancing and translating MOF-based nanodrugs into pre-clinical and clinical applications.

Graphical abstract: Nanoscale MOFs in nanomedicine applications: from drug delivery to therapeutic agents

Article information

Article type
Review Article
Submitted
06 jan 2023
Accepted
02 mar 2023
First published
03 mar 2023

J. Mater. Chem. B, 2023,11, 3273-3294

Nanoscale MOFs in nanomedicine applications: from drug delivery to therapeutic agents

Z. Sun, T. Li, T. Mei, Y. Liu, K. Wu, W. Le and Y. Hu, J. Mater. Chem. B, 2023, 11, 3273 DOI: 10.1039/D3TB00027C

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