Issue 43, 2023

Fatimanols Y and Z: two neo-clerodane diterpenoids from Teucrium yemense

Abstract

Teucrium yemense (Defl.), a medicinal plant, grows in Yemen and Saudi Arabia and is also referred to as Reehal Fatima. The plant has a long history of use in these regions for the treatment of diabetes, rheumatism, and renal conditions. Phytochemical investigation of the aerial parts of T. yemense yielded two previously undescribed neo-clerodane diterpenoids, namely fatimanols Y and Z (1 and 2) along with the known teulepicephin (3), 8-acetylharpagide (4) and teucardosid (5). Structure elucidation was accomplished from their 1D and 2D NMR, ECD, and MS characteristics as well as by comparing them to related reported compounds. The new molecules expand understanding of secondary metabolites of this genus. Compounds 1–5 did not show antimicrobial activity against various bacterial and fungal strains.

Graphical abstract: Fatimanols Y and Z: two neo-clerodane diterpenoids from Teucrium yemense

Supplementary files

Article information

Article type
Paper
Submitted
06 sep 2023
Accepted
10 okt 2023
First published
20 okt 2023
This article is Open Access
Creative Commons BY license

RSC Adv., 2023,13, 30264-30268

Fatimanols Y and Z: two neo-clerodane diterpenoids from Teucrium yemense

A. Elbermawi, F. Zulfiqar, I. A. Khan and Z. Ali, RSC Adv., 2023, 13, 30264 DOI: 10.1039/D3RA06083G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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