Issue 5, 2023

Flavonoids and related privileged scaffolds as potential urease inhibitors: a review

Abstract

Infections caused by bacteria are a significant issue on a global scale, and imperative action is required to discover novel or improved therapeutic agents. Flavonoids are a class of plant-derived compounds that have a variety of potentially useful bioactivities. These activities include immediate antimicrobial properties, synergistic effect with antimicrobials, ferocious repression of pathogenicity, anti-urease activity etc. This review summarizes current studies concerning anti-urease actions of flavonoids as well as structural–activity correlation investigations of the flavonoid core structure. It is possible that if researchers investigate the many structural changes that may be made in flavonoid rings, they'll be able to build up novel compounds that have powerful and effective anti-urease properties.

Graphical abstract: Flavonoids and related privileged scaffolds as potential urease inhibitors: a review

Article information

Article type
Review Article
Submitted
28 dec 2022
Accepted
16 jan 2023
First published
23 jan 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 3210-3233

Flavonoids and related privileged scaffolds as potential urease inhibitors: a review

M. M. Al-Rooqi, E. U. Mughal, Q. A. Raja, E. M. Hussein, N. Naeem, A. Sadiq, B. H. Asghar, Z. Moussa and S. A. Ahmed, RSC Adv., 2023, 13, 3210 DOI: 10.1039/D2RA08284E

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