Issue 14, 2023

Ecofriendly aminochalcogenation of alkenes: a green alternative to obtain compounds with potential anti-SARS-CoV-2 activity

Abstract

Here, we report a solvent- and metal-free methodology for the aminochalcogenation of alkenes, using molecular iodine as a catalyst, DMSO as a stoichiometric oxidant, and different nucleophiles under microwave irradiation. This ecofriendly approach provided the desired products with good to excellent yields in just 20 minutes. In addition, twenty compounds obtained by this methodology were referred for evaluation of potential antiviral activity against the coronavirus SARS-CoV-2. Two of the evaluated compounds (named 4d and 5b) showed potent antiviral activity, with a low cytotoxic profile resulting in a promising selectivity index.

Graphical abstract: Ecofriendly aminochalcogenation of alkenes: a green alternative to obtain compounds with potential anti-SARS-CoV-2 activity

Supplementary files

Article information

Article type
Paper
Submitted
20 dec 2022
Accepted
09 feb 2023
First published
10 feb 2023

New J. Chem., 2023,47, 6591-6601

Ecofriendly aminochalcogenation of alkenes: a green alternative to obtain compounds with potential anti-SARS-CoV-2 activity

L. S. Gomes, J. S. S. Neto, I. di Leo, C. G. Barbosa, C. B. Moraes, L. H. Freitas-Junior, B. Rizzuti, C. Santi and V. Nascimento, New J. Chem., 2023, 47, 6591 DOI: 10.1039/D2NJ06218F

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