Issue 44, 2023

Electrochemical C–F bond activation of trifluoromethylarenes using silylium ions

Abstract

We report a mild, electrochemical trihydrodefluorination (e-THDF) for breaking highly stable C–F bonds in trifluoromethyl arenes to form the corresponding methyl arene products. Uniquely, this “green” approach relies on the in situ generation of Lewis acidic silyl cations that mediate fluoride abstraction. Overall, e-THDF has significantly improved functional group tolerance over current methods and should inspire the continued development of defluorinative processes.

Graphical abstract: Electrochemical C–F bond activation of trifluoromethylarenes using silylium ions

Supplementary files

Article information

Article type
Communication
Submitted
24 apr 2023
Accepted
09 maj 2023
First published
09 maj 2023

Chem. Commun., 2023,59, 6694-6697

Electrochemical C–F bond activation of trifluoromethylarenes using silylium ions

S. Mondal, B. Stevanovic, E. Butler, J. W. Wang and M. W. Meanwell, Chem. Commun., 2023, 59, 6694 DOI: 10.1039/D3CC01850D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements