Issue 8, 2022

Homogeneous catalyst modifier for alkyne semi-hydrogenation: systematic screening in an automated flow reactor and computational study on mechanisms

Abstract

The selectivity of palladium catalysed hydrogenation can be improved by adding a homogeneous modifier (or poison) such as quinoline to the reaction mixture. Although such selectivity improvement by modifiers (selective catalyst poisoning) has been known for decades, we still know little about them. We, ultimately, cannot select a modifier to improve a particular process. In this study, 21 types of modifiers are screened for the semi-hydrogenation of alkynes with varying catalyst type, reaction time, and target substrate using an automated flow reactor system. All of the studied variables changed affected hydrogenation activity and selectivity confirming the effectiveness of a multi-parameter optimization. 1,10-phenanthroline marked the best selectivity beyond quinoline. The density functional theory (DFT) calculations suggest that 1,10-phenanthroline has a remarkable ability to adsorb on the irregular surface of the catalyst that effects undesirable reaction.

Graphical abstract: Homogeneous catalyst modifier for alkyne semi-hydrogenation: systematic screening in an automated flow reactor and computational study on mechanisms

Supplementary files

Article information

Article type
Paper
Submitted
11 apr 2022
Accepted
27 apr 2022
First published
16 maj 2022
This article is Open Access
Creative Commons BY license

React. Chem. Eng., 2022,7, 1818-1826

Homogeneous catalyst modifier for alkyne semi-hydrogenation: systematic screening in an automated flow reactor and computational study on mechanisms

S. Asano, S. J. Adams, Y. Tsuji, K. Yoshizawa, A. Tahara, J. Hayashi and N. Cherkasov, React. Chem. Eng., 2022, 7, 1818 DOI: 10.1039/D2RE00147K

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