Issue 18, 2022

High-yield halide-assisted synthesis of metal–organic framework UiO-based nanocarriers

Abstract

The synthesis of nanosized metal–organic frameworks (NMOFs) is requisite for their application as injectable drug delivery systems (DDSs) and other biorelevant purposes. Herein, we have critically examined the role of different synthetic parameters leading to the production of UiO-66 crystals smaller than 100 nm. Of note, we demonstrate the co-modulator role conferred by halide ions, not only to produce NMOFs with precise morphology and size, but also to significantly improve the reaction yield. The resulting NMOFs are highly crystalline and exhibit sustained colloidal stability in different biologically relevant media. As a proof of concept, these NMOFs were loaded with Rhodamine 6G (R6G), which remained trapped in most common biologically relevant media. When incubated with living mammalian cells, the R6G-loaded NMOFs were efficiently internalized and did not impair cell viability even at relatively high doses.

Graphical abstract: High-yield halide-assisted synthesis of metal–organic framework UiO-based nanocarriers

Supplementary files

Article information

Article type
Paper
Submitted
17 dec 2021
Accepted
15 mar 2022
First published
25 apr 2022
This article is Open Access
Creative Commons BY-NC license

Nanoscale, 2022,14, 6789-6801

High-yield halide-assisted synthesis of metal–organic framework UiO-based nanocarriers

M. Ceballos, M. Cedrún-Morales, M. Rodríguez-Pérez, S. Funes-Hernando, J. M. Vila-Fungueiriño, G. Zampini, M. F. Navarro Poupard, E. Polo, P. del Pino and B. Pelaz, Nanoscale, 2022, 14, 6789 DOI: 10.1039/D1NR08305H

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