Issue 43, 2022

Multifunctional molecules with a bipyridyl core ameliorate multifaceted amyloid toxicity

Abstract

A series of 2,2′-bipyridine derivatives appended with structurally unique biomolecular auxiliaries were synthesized and investigated for their ability to ameliorate multifaceted amyloid toxicity. Our results highlight the roles of the metal-chelating bipyridine core and functional auxiliaries in effectively modulating metal-independent and -dependent amyloid toxicity, and oxidative stress observed in Alzheimer's disease (AD).

Graphical abstract: Multifunctional molecules with a bipyridyl core ameliorate multifaceted amyloid toxicity

Supplementary files

Article information

Article type
Communication
Submitted
25 feb 2022
Accepted
25 apr 2022
First published
25 apr 2022

Chem. Commun., 2022,58, 6288-6291

Multifunctional molecules with a bipyridyl core ameliorate multifaceted amyloid toxicity

D. Padhi, C. Balachandra, M. Ramesh and T. Govindaraju, Chem. Commun., 2022, 58, 6288 DOI: 10.1039/D2CC01168A

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