Issue 34, 2022

Metallation of sensitive fluoroarenes using a potassium TMP-zincate supported by a silyl(bis)amido ligand

Abstract

Combining a bulky bis(amide) and a reactive one-coordinate TMP (2,2,6,6-tetramethylpiperidide) ligand, a new mixed K/Zn heteroleptic base has been developed for regioselective zincation of fluoroarenes. This special ligand set allows for trapping and structural authentication of the first intermediates of direct Zn–H exchange of fluoroarenes obtained via deprotonative metallation, providing mechanistic insights of the processes involved.

Graphical abstract: Metallation of sensitive fluoroarenes using a potassium TMP-zincate supported by a silyl(bis)amido ligand

Supplementary files

Article information

Article type
Communication
Submitted
16 feb 2022
Accepted
07 mar 2022
First published
09 mar 2022
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2022,58, 5292-5295

Metallation of sensitive fluoroarenes using a potassium TMP-zincate supported by a silyl(bis)amido ligand

P. Mastropierro, A. R. Kennedy and E. Hevia, Chem. Commun., 2022, 58, 5292 DOI: 10.1039/D2CC00979J

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