Issue 4, 2021

Photo-triggered Zn2+ release for the regulation of zinc enzymes

Abstract

Zinc ions (Zn2+) play a critical role in the regulation of zinc enzymes and cell metabolism. However, previous Zn2+ delivery methods are usually based on pH-responsive zinc coordination complexes, which are difficult for the precise control of Zn2+ release at desired locations. To tackle this challenge, we herein developed a photo-triggered Zn2+ release system based on HBTH–Zn–TAT nanoparticles (NPs) with 2-(2-hydroxyphenyl)-benzothiazolines (HBTH) as the Zn2+ ligand, DSPE–PEG/DSPE–PEG–Mal polymers as the matrix and TAT peptide as the cell penetrating ligand. HBTH–Zn–TAT NPs can quickly release Zn2+ under white light irradiation and efficiently regulate extra- and intracellular zinc enzyme activities, such as carbonic anhydrase, caspase-3 and protein phosphatase type 2A (PP2A). Based on the advantages of the photo-triggered release of Zn2+ with a high spatiotemporal resolution, HBTH–Zn–TAT NPs are promising for the regulation of zinc enzymes and corresponding bioactivities.

Graphical abstract: Photo-triggered Zn2+ release for the regulation of zinc enzymes

Supplementary files

Article information

Article type
Research Article
Submitted
15 nov 2020
Accepted
22 dec 2020
First published
23 dec 2020

Mater. Chem. Front., 2021,5, 1824-1829

Photo-triggered Zn2+ release for the regulation of zinc enzymes

M. Zhang, Y. Jia, M. Gao, L. Ren and B. Z. Tang, Mater. Chem. Front., 2021, 5, 1824 DOI: 10.1039/D0QM00947D

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