Issue 72, 2021

Minimalistic peptidic scaffolds harbouring an artificial carbene-containing amino acid modulate reductase activity

Abstract

Inspired by the boom of new artificial metalloenzymes, we developed an Fmoc-protected histidinium salt (Hum) as N-heterocyclic carbene precursor. Hum was placed via solid-phase peptide synthesis into short 7-mer peptides. Upon iridation, the metallo-peptidic construct displayed activity in catalytic hydrogenation that outperforms small molecule analogues and which is dependent on the peptide sequence, a typical feature of metalloenzymes.

Graphical abstract: Minimalistic peptidic scaffolds harbouring an artificial carbene-containing amino acid modulate reductase activity

Supplementary files

Article information

Article type
Communication
Submitted
15 jun 2021
Accepted
06 aug 2021
First published
06 aug 2021
This article is Open Access
Creative Commons BY license

Chem. Commun., 2021,57, 9068-9071

Minimalistic peptidic scaffolds harbouring an artificial carbene-containing amino acid modulate reductase activity

K. Lenzen, M. Planchestainer, I. Feller, D. R. Padrosa, F. Paradisi and M. Albrecht, Chem. Commun., 2021, 57, 9068 DOI: 10.1039/D1CC03158A

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