Issue 40, 2020

Two-dimensional iron MOF nanosheet as a highly efficient nanozyme for glucose biosensing

Abstract

Two-dimensional (2D) nanomaterials are attractive in catalysis due to their rich accessible active sites. Iron-based metal organic frameworks (MOFs) are promising nanozymes because of their iron center and pore structure. However, it is challenging to obtain iron-based 2D MOF nanozymes due to the coordinated form of iron. Herein, we report a cation substitution strategy to transform an easily obtained Cu(HBTC)(H2O)3 (represented as Cu(HBTC)-1, the product of only two carboxylate groups in 1,3,5-benzenetricarboxylic acid (H3BTC) ligands linked by Cu ions) nanosheet into a 2D Fe-BTC nanosheet, which was characterized by SEM (scanning electron microscopy), AFM (atomic force microscopy), XPS (X-ray photoelectron spectroscopy), FT-IR (Fourier transform infrared spectroscopy), and XRD (X-ray diffraction). The 2D Fe-BTC nanosheet can catalyze TMB (3,3′,5,5′-tetramethylbenzidine) oxidation by H2O2, showing its intrinsic peroxidase mimetic characteristic. The catalytic performance of 2D Fe-BTC was superior to those of its template Cu(HBTC)-1 nanosheet and 3D MIL-100(Fe). Their catalytic activities follow the order of 2D Fe-BTC > MIL-100(Fe) > 2D Cu(HBTC)-1. The peroxidase-like activity of 2D Fe-BTC is 77 times that of its template Cu(HBTC)-1, and 2.2 times that of MIL-100(Fe), a well known 3D crystalline form of iron trimesates. The Km values of 2D Fe-BTC for TMB and H2O2 were 0.2610 mM and 0.0334 mM, which were 1.6 and 1.9-fold lower than those of 3D MIL-100(Fe), respectively. The TMB oxidation rate and H2O2 reduction rate at unit mass concentration of the catalyst (Kw) for 2D Fe-BTC were 2.7–72.3 and 1.5–37.9 times those for the previously reported 3D MOF nanozymes, respectively. In terms of the excellent peroxidase mimetic characteristic of 2D Fe-BTC, a sensitive and selective colorimetric biosensing platform for hydrogen peroxide and glucose was developed. The linear ranges are 0.04–30 μM and 0.04–20 μM for H2O2 and glucose, with a low detection limit of 36 nM and 39 nM, respectively. The assay was satisfactorily applied to glucose determination in biological matrices.

Graphical abstract: Two-dimensional iron MOF nanosheet as a highly efficient nanozyme for glucose biosensing

Supplementary files

Article information

Article type
Paper
Submitted
28 jun 2020
Accepted
31 aug 2020
First published
31 aug 2020

J. Mater. Chem. B, 2020,8, 9295-9303

Two-dimensional iron MOF nanosheet as a highly efficient nanozyme for glucose biosensing

A. Yuan, Y. Lu, X. Zhang, Q. Chen and Y. Huang, J. Mater. Chem. B, 2020, 8, 9295 DOI: 10.1039/D0TB01598A

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