Issue 17, 2020

Synthetic pathways to tetrahydrocannabinol (THC): an overview

Abstract

The therapeutic effects of molecules produced by the plant species Cannabis sativa have since their discovery captured the interest of scientists and society, and have spurred the development of a multidisciplinary scientific field with contributions from biologists, medical specialists and chemists. Decades after the first isolation of some of the most bioactive tetrahydrocannabinols, current research is mostly dedicated to exploiting the chemical versatility of this relevant compound class with regard to its therapeutic potential. This review will primarily focus on synthetic pathways utilised for the synthesis of tetrahydrocannabinols and derivatives thereof, including chiral pool-based and asymmetric chemo- and biocatalytic approaches.

Graphical abstract: Synthetic pathways to tetrahydrocannabinol (THC): an overview

Article information

Article type
Review Article
Submitted
03 mar 2020
Accepted
31 mar 2020
First published
31 mar 2020
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2020,18, 3203-3215

Synthetic pathways to tetrahydrocannabinol (THC): an overview

V. R. L. J. Bloemendal, J. C. M. van Hest and F. P. J. T. Rutjes, Org. Biomol. Chem., 2020, 18, 3203 DOI: 10.1039/D0OB00464B

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements