Issue 98, 2020

Protein-recruiting synthetic molecules targeting the Golgi surface

Abstract

Organelle-localizable small-molecule ligands are valuable tools for spatiotemporally controlling protein localization and signaling processes in living cells. Here, we present synthetic ligands that specifically localize to the Golgi surface. The ligands can rapidly recruit their target proteins from the cytoplasm to the Golgi and be applied to manipulate signaling proteins and lipids on the Golgi membrane, offering a new useful chemical tool for the study and control of Golgi/cell functions.

Graphical abstract: Protein-recruiting synthetic molecules targeting the Golgi surface

Supplementary files

Article information

Article type
Communication
Submitted
16 okt 2020
Accepted
20 nov 2020
First published
20 nov 2020

Chem. Commun., 2020,56, 15422-15425

Protein-recruiting synthetic molecules targeting the Golgi surface

S. Sawada, A. Nakamura, T. Yoshii, K. Kuwata, F. Nakatsu and S. Tsukiji, Chem. Commun., 2020, 56, 15422 DOI: 10.1039/D0CC06908F

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