Issue 92, 2020

Ultrastable radical-doped coordination compounds with antimicrobial activity against antibiotic-resistant bacteria

Abstract

In the present work, we have introduced a series of stable radical-doped coordination compounds composed of donor–acceptor structures and shown to produce organic radicals in situ as a result of unconventional lone pair–π interactions in ambient conditions. Inconspicuous lone pair–π and C–H⋯π interactions were shown to play a key role in self-assembly as well as the charge transfer process, resulting in a long-lived charge-separated state able to generate organic radicals. The resultant species displayed broad-spectrum antimicrobial activity, including against multi-drug-resistant bacteria. This study unveiled the promise of reactive organic radical-doped materials as a new platform for developing antimicrobial agents that can overcome antibiotic resistance.

Graphical abstract: Ultrastable radical-doped coordination compounds with antimicrobial activity against antibiotic-resistant bacteria

Supplementary files

Article information

Article type
Communication
Submitted
23 sep 2020
Accepted
23 okt 2020
First published
24 okt 2020

Chem. Commun., 2020,56, 14353-14356

Ultrastable radical-doped coordination compounds with antimicrobial activity against antibiotic-resistant bacteria

H. Ke, F. Hu, L. Meng, Q. Chen, Q. Lai, Z. Li, Z. Huang, J. Liao, J. Qiu and C. Lu, Chem. Commun., 2020, 56, 14353 DOI: 10.1039/D0CC06379G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements