Issue 5, 2020

Exploiting structure–activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants

Abstract

We report the design, synthesis, immunological evaluation, and conformational analysis of new saponin variants as promising vaccine adjuvants. These studies have provided expedient synthetic access to streamlined adjuvant-active saponins and yielded molecular-level insights into saponin conformation that correlated with their in vivo adjuvant activities.

Graphical abstract: Exploiting structure–activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants

Supplementary files

Article information

Article type
Communication
Submitted
04 okt 2019
Accepted
12 nov 2019
First published
12 dec 2019
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2020,56, 719-722

Exploiting structure–activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants

M. Ghirardello, A. Ruiz-de-Angulo, N. Sacristan, D. Barriales, J. Jiménez-Barbero, A. Poveda, F. Corzana, J. Anguita and A. Fernández-Tejada, Chem. Commun., 2020, 56, 719 DOI: 10.1039/C9CC07781B

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