Issue 5, 2019

Hybrid particles derived from alendronate and bioactive glass for treatment of osteoporotic bone defects

Abstract

Osteoporosis is the most widespread metabolic bone disease which represents a major public health burden. Consequently, novel biomaterials with a strong capacity to regenerate osteoporotic bone defects are urgently required. In view of the anti-osteoporotic and osteopromotive efficacy of alendronate and 45S5 bioactive glass, respectively, we investigated the feasibility to synthesize novel hybrid particles by exploiting the strong interactions between these two compounds. Herein, we demonstrate the facile preparation of a novel class of hybrid particles of tunable morphology, chemical composition and structure. These hybrid particles (i) release alendronate and various inorganic elements (Ca, Na, Si, and P) in a controlled manner, (ii) exhibit a strong anti-osteoclastic effect in vitro, and (iii) stimulate regeneration of osteoporotic bone in vivo. Consequently, this novel class of hybrid biomaterials opens up new avenues of research on the design of bone substitutes with specific activity to facilitate regeneration of bone defects in osteoporotic patients.

Graphical abstract: Hybrid particles derived from alendronate and bioactive glass for treatment of osteoporotic bone defects

Supplementary files

Article information

Article type
Paper
Submitted
20 nov 2018
Accepted
26 dec 2018
First published
04 jan 2019

J. Mater. Chem. B, 2019,7, 796-808

Hybrid particles derived from alendronate and bioactive glass for treatment of osteoporotic bone defects

M. Diba, W. A. Camargo, T. Zinkevich, A. Grünewald, R. Detsch, Y. Kabiri, A. P. M. Kentgens, A. R. Boccaccini, J. J. J. P. van den Beucken and S. C. G. Leeuwenburgh, J. Mater. Chem. B, 2019, 7, 796 DOI: 10.1039/C8TB03062F

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