Issue 44, 2018

A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells

Abstract

Heat stroke is a lethal condition which can cause dysfunction in the central nervous system, multi-organ damage and even death. However, there is still limited knowledge of the detailed mechanism about the roles of lysosomes in heat stroke due to lack of effective tools. Herein, we introduce our previously developed hemicyanine with a large D–π–A structure as the key fluorophore to develop a new fluorescent probe (CPY) for ratiometric mapping of lysosomal pH changes in live cells under a heat shock stimulus.

Graphical abstract: A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells

Supplementary files

Article information

Article type
Communication
Submitted
23 mar 2018
Accepted
09 apr 2018
First published
11 apr 2018
This article is Open Access
Creative Commons BY license

Chem. Commun., 2018,54, 5518-5521

A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells

L. Wu, Y. Wang, T. D. James, N. Jia and C. Huang, Chem. Commun., 2018, 54, 5518 DOI: 10.1039/C8CC02330A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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