Issue 9, 2017

Large-area assembly of halloysite nanotubes for enhancing the capture of tumor cells

Abstract

Here, polystyrene sulfonate sodium (PSS) modified Halloysite nanotubes (HNTs) were self-assembled into a patterned coating on a glass substrate with ordered nanotube arrays in a slit-like confined space. The microstructure of the formed patterned HNTs coating was investigated. The formed strips are more regular and almost parallel to each other with an increase in HNTs concentration. The HNTs coating formed from the 2% PSS-HNTs dispersion has the maximum nanotube alignment degree. The patterned HNTs coating was employed to capture tumor cells. The tumor cells can be captured by the HNTs coating effectively compared with a smooth glass surface due to the enhanced topographic interactions between the HNTs coating and cancer cells. The HNTs coating prepared from the 2% PSS-HNTs dispersion has the highest capture yield which is due to the ordered nanotube arrangement and the appropriate surface roughness. The HNTs coating was further conjugated with anti-EpCAM, which leads to the capture yield of MCF-7 cells reaching 92% within 3 h. The HNTs coating can capture 8 MCF-7 cells from 1 mL artificial blood samples spiked with 10 MCF-7 cells, showing the promising applications of HNTs in clinical circulating tumor cell capture for early diagnosis and monitoring of cancer patients.

Graphical abstract: Large-area assembly of halloysite nanotubes for enhancing the capture of tumor cells

Supplementary files

Article information

Article type
Paper
Submitted
28 sep 2016
Accepted
16 jan 2017
First published
17 jan 2017

J. Mater. Chem. B, 2017,5, 1712-1723

Large-area assembly of halloysite nanotubes for enhancing the capture of tumor cells

R. He, M. Liu, Y. Shen, Z. Long and C. Zhou, J. Mater. Chem. B, 2017, 5, 1712 DOI: 10.1039/C6TB02538B

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