Issue 26, 2016

HPLC enantioseparation on a homochiral MOF–silica composite as a novel chiral stationary phase

Abstract

The last frontier in the development of chiral stationary phases for chromatographic enantioseparation involves homochiral metal–organic frameworks (MOFs). Using enantiopure (R)-2,2′-dihydroxy-1,1′-binaphthalene-6,6′-dicarboxylic acid as a starting material, we prepared three homochiral MOFs that were further used as chiral stationary phases for high-performance liquid chromatography to separate the enantiomers of various kinds of racemic sulfoxides, sec-alcohols, β-lactams, benzoins, flavanones and epoxides. The experimental results showed excellent performances for enantioseparation, and highlighted that enantioseparation on homochiral MOF columns is practical.

Graphical abstract: HPLC enantioseparation on a homochiral MOF–silica composite as a novel chiral stationary phase

Supplementary files

Article information

Article type
Paper
Submitted
12 dec 2015
Accepted
15 feb 2016
First published
16 feb 2016

RSC Adv., 2016,6, 21293-21301

HPLC enantioseparation on a homochiral MOF–silica composite as a novel chiral stationary phase

K. Tanaka, T. Muraoka, Y. Otubo, H. Takahashi and A. Ohnishi, RSC Adv., 2016, 6, 21293 DOI: 10.1039/C5RA26520G

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