Issue 8, 2013

Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs

Abstract

Floating polymeric microcapsules that simultaneously entrap multiple drugs were prepared using a solid/water/oil/water emulsion solvent evaporation method, based on harnessing interfacial phenomena and manipulation of the solvent removal process. The fabricated microcapsules exhibited excellent buoyancy in simulated gastric fluid and provided controlled and sustained release of multiple drugs for up to 24 h, thus revealing their potential as a rate-controlled oral drug delivery system.

Graphical abstract: Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs

Supplementary files

Article information

Article type
Communication
Submitted
06 dec 2012
Accepted
03 jan 2013
First published
08 jan 2013
This article is Open Access
Creative Commons BY-NC license

J. Mater. Chem. B, 2013,1, 1090-1095

Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs

W. L. Lee, P. Wee, C. Nugraha and S. C. J. Loo, J. Mater. Chem. B, 2013, 1, 1090 DOI: 10.1039/C2TB00495J

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