Issue 31, 2007

Mesoporous silicananoparticle based controlled release, drug delivery, and biosensor systems

Abstract

Recent advancements in controlling the surface properties and particle morphology of the structurally defined mesoporous silica materials with high surface area (>700 m2 g−1) and pore volume (>1 cm3 g−1) have significantly enhanced their biocompatibility. Various methods have been developed for the functionalization of both the internal pore and exterior particle surfaces of these silicates with a tunable pore diameter ranging from 2 to 30 nm and a narrow pore size distribution. Herein, we review the recent research progress on the design of functional mesoporous silica materials for stimuli-responsive controlled release delivery of pharmaceutical drugs, genes, and other chemicals. Furthermore, the recent breakthroughs in utilizing these nanoscale porous materials as sensors for selective detections of various neurotransmitters and biological molecules are summarized.

Graphical abstract: Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems

Article information

Article type
Feature Article
Submitted
05 feb 2007
Accepted
02 mar 2007
First published
20 mar 2007

Chem. Commun., 2007, 3236-3245

Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems

B. G. Trewyn, S. Giri, I. I. Slowing and V. S.-Y. Lin, Chem. Commun., 2007, 3236 DOI: 10.1039/B701744H

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