Issue 3, 2024

Interactions and reactivity in crystalline intermediates of mechanochemical cyclorhodation reactions

Abstract

There is experimental evidence that solid mixtures of the rhodium dimer [Cp*RhCl2]2 and benzo[h] quinoline (BHQ) produce two different polymorphic molecular cocrystals called and under ball milling conditions. The addition of NaOAc to the mixture leads to the formation of the rhodacycle [Cp*Rh-(BHQ)Cl], where the central Rh atom retains its tetracoordinate character. Isolate reacts with NaOAc leading to the same rhodacycle while isolate does not under the same conditions. We show that the puzzling difference in reactivity between the two cocrystals can be traced back to fundamental aspects of the intermolecular interactions between the BHQ and [Cp*RhCl2]2 fragments in the crystalline environment. To support this view, we report a number of descriptors of the nature and strength of chemical bonds and intermolecular interactions in the extended solids and in a cluster model. We calculate formal quantum mechanical descriptors based on electronic structure, electron density, and binding and interaction energies including an energy decomposition analysis. Without exception, all descriptors point to being a transient structure higher in energy than with larger local and global electrophilic and nucleophilic powers, a more favorable spatial and energetic distribution of the frontier orbitals, and a more fragile crystal structure.

Graphical abstract: Interactions and reactivity in crystalline intermediates of mechanochemical cyclorhodation reactions

Supplementary files

Article information

Article type
Paper
Submitted
30 aug 2023
Accepted
30 nov 2023
First published
08 dec 2023

Phys. Chem. Chem. Phys., 2024,26, 2228-2241

Interactions and reactivity in crystalline intermediates of mechanochemical cyclorhodation reactions

S. Gómez, S. Gómez, N. Rojas-Valencia, J. G. Hernández, K. J. Ardila-Fierro, T. Gómez, C. Cárdenas, C. Hadad, C. Cappelli and A. Restrepo, Phys. Chem. Chem. Phys., 2024, 26, 2228 DOI: 10.1039/D3CP04201D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements